Systematic Review and Meta-Analysis of the Effect of Statins on Circulating E-Selectin, L-Selectin, and P-Selectin [PDF]
Biomedicines, 2021 The pleiotropic effects of statins might involve preventing inflammatory cell adhesion to the endothelium, which is a critical step in the pathogenesis of atherosclerosis.
Angelo Zinellu, Arduino A. Mangoni
doaj +5 more sources
A cell-extrinsic ligand acquired by activated T cells in lymph node can bridge L-selectin and P-selectin. [PDF]
PLoS ONE, 2018 P-selectin expressed on activated endothelia and platelets supports recruitment of leukocytes expressing P-selectin ligand to sites of inflammation.
Douglas A Carlow +2 more
doaj +2 more sources
Circulating selectins as potential biomarkers for sarcopenia: a case-control study [PDF]
Frontiers in MedicineBackgroundThis study investigates the association between circulating E-selectin, L-selectin, and P-selectin levels and sarcopenia in older adults.MethodsWe conducted a case-control study of 325 older adults (261 controls, 64 sarcopenia cases ...
Hu Zhang +7 more
doaj +2 more sources
P-selectin glycoprotein ligand-1 forms dimeric interactions with E-selectin but monomeric interactions with L-selectin on cell surfaces. [PDF]
PLoS ONE, 2013 Interactions of selectins with cell surface glycoconjugates mediate the first step of the adhesion and signaling cascade that recruits circulating leukocytes to sites of infection or injury.
Yan Zhang +5 more
doaj +2 more sources
L-selectin: A Major Regulator of Leukocyte Adhesion, Migration and Signaling
Frontiers in Immunology, 2019 L-selectin (CD62L) is a type-I transmembrane glycoprotein and cell adhesion molecule that is expressed on most circulating leukocytes. Since its identification in 1983, L-selectin has been extensively characterized as a tethering/rolling receptor.
Aleksandar Ivetić, Ivetić Aleksandar
exaly +3 more sources
E-selectin in vascular pathophysiology [PDF]
Frontiers in ImmunologySelectins are a group of Ca2+-dependent, transmembrane type I glycoproteins which attract cell adhesion and migration. E-selectin is exclusively expressed in endothelial cells, and its expression is strongly enhanced upon activation by pro-inflammatory ...
Jinjin Zhang +9 more
doaj +2 more sources
Regulation of PSGL-1 Interactions with L-selectin, P-selectin, and E-selectin [PDF]
Journal of Biological Chemistry, 2005 P-selectin glycoprotein ligand-1 (PSGL-1) interactions with selectins regulate leukocyte migration in inflammatory lesions. In mice, selectin ligand activity regulating leukocyte recruitment and lymphocyte homing into lymph nodes results from the sum of ...
Manuel Martinez +6 more
openaire +2 more sources
Frontiers in Molecular Biosciences, 2023 Abdominal aortic aneurysm (AAA) is a common disease and highly lethal if untreated. The progressive dilatation of the abdominal aorta is accompanied by degradation and remodeling of the vessel wall due to chronic inflammation.
Lisa Maria Metz +11 more
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Epsins Negatively Regulate Aortic Endothelial Cell Function by Augmenting Inflammatory Signaling
Cells, 2021 Background: The endothelial epsin 1 and 2 endocytic adaptor proteins play an important role in atherosclerosis by regulating the degradation of the calcium release channel inositol 1,4,5-trisphosphate receptor type 1 (IP3R1).
Yunzhou Dong +7 more
doaj +1 more source
Inflammatory Cell Recruitment in Cardiovascular Disease
Frontiers in Cell and Developmental Biology, 2021 Atherosclerosis, the main underlying pathology for myocardial infarction and stroke, is a chronic inflammatory disease of middle-sized to large arteries that is initiated and maintained by leukocytes infiltrating into the subendothelial space.
Timoteo Marchini +6 more
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