Results 21 to 30 of about 74,821 (300)
, 2022 Nanodiamond (ND) has been developed as a carrier to conduct various in vivo diagnostic and therapeutic uses. Safety is one of the major considerations, while the hemocompatibility of ND is not clearly addressed.
Lu-Chu Ke (12339820) +6 more
core +1 more source
Nanoparticles for the Optical Imaging of Tumor selectin
Neoplasia: An International Journal for Oncology Research, 2005 We designed a fluorescent peptide-magnetic noneparticle conjugate that images selectin expression in mouse xenograft models of Lewis lung carcinoma. (LLC) by fluorescence reflectance imaging. It was synthesized by attaching the selectin-binding peptide. (
Martin Funovics +4 more
doaj +1 more source
Dynamic biochemical tissue analysis detects functional L-selectin ligands on colon cancer tissues. [PDF]
PLoS ONE, 2017 A growing body of evidence suggests that L-selectin ligands presented on circulating tumor cells facilitate metastasis by binding L-selectin presented on leukocytes. Commonly used methods for detecting L-selectin ligands on tissues, e.g., immunostaining,
Grady E Carlson +6 more
doaj +1 more source
Blood, 2015 In this issue of Blood , [Etulain et al][1] have added to the knowledge of neutrophil extracellular traps (NETs) by defining the mechanisms involved in platelet-triggered NET formation.[1][2] NETs have been the subject of intense investigation since their description over a decade ago.[2][3]
openaire +2 more sources
Synthesis of a Potent Antagonist of E-Selectin
, 2016 A synthesis of an antagonist of E-selectin previously reported by a group at Novartis Pharma in Basel is described. An important feature involves the formation of an ether linkage based on a RhII-catalyzed reaction.
Vincent Mascitti (1393702) +2 more
core +2 more sources
Mac-2 binding protein is a novel E-selectin ligand expressed by breast cancer cells. [PDF]
PLoS ONE, 2012 Hematogenous metastasis involves the adhesion of circulating tumor cells to vascular endothelium of the secondary site. We hypothesized that breast cancer cell adhesion is mediated by interaction of endothelial E-selectin with its glycoprotein counter ...
Venktesh S Shirure +2 more
doaj +1 more source
Altered Cell Adhesion and Glycosylation Promote Cancer Immune Suppression and Metastasis
Frontiers in Immunology, 2019 Cell-cell interactions and cell adhesion are key mediators of cancer progression and facilitate hallmarks of cancer including immune evasion and metastatic dissemination.
Heinz Läubli +2 more
doaj +1 more source
, 2022 Activation of integrins is crucial for recruitment of flowing leukocytes to inflammatory or injured vascular sites, but their spatiotemporal characteristics are incompletely understood. We discovered that β2-integrin activation over the entire surface of
Quhuan Li (9666770) +11 more
core +1 more source
Hepatology, EarlyView., 2022 CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli +13 more
wiley +1 more source
Microglial Lectins in Health and Neurological Diseases
Frontiers in Molecular Neuroscience, 2018 Microglia are the innate sentinels of the central nervous system (CNS) and are responsible for the homeostasis and immune defense of the CNS. Under the influence of the local environment and cell-cell interaction, microglia exhibit a multidimensional and
Jian Jing Siew +3 more
doaj +1 more source