Results 1 to 10 of about 15,861 (227)

Analysis of a novel immune checkpoint, Siglec-15, in pancreatic ductal adenocarcinoma

Journal of Pathology: Clinical Research, 2022
Siglec‐15, a novel immune checkpoint, is an emerging target for next‐generation cancer immunotherapy. However, the role of Siglec‐15 in pancreatic ductal adenocarcinoma (PDAC) remains poorly understood. We investigated the expression of Siglec‐15 and its
Shuangni Yu, Yue Zhang
exaly   +2 more sources

Sickle red blood cell/Siglec-9 interactions contribute to neutrophil activation in SCD and are associated with survival [PDF]

Blood Red Cells & Iron
: Sialic acid-binding immunoglobulin-like lectin-9 (Siglec-9) is a neutrophil inhibitory receptor. Prior studies have shown that sickle red blood cells (SS RBCs) abnormally engage neutrophil Siglec-9, suggesting that SS RBCs may not be able to ...
Grace M. Lee, Kimberly Boyle, Milena Batchvarova, Martha Delahunty, Marilyn J. Telen   +4 more
doaj   +2 more sources

Development of Siglec-9 Blocking Antibody to Enhance Anti-Tumor Immunity

Frontiers in Oncology, 2021
Sialic acid-binding Immunoglobulin-like lectin-9 (Siglec-9) is a glyco-immune negative checkpoint expressed on several immune cells. Siglec-9 exerts its inhibitory effects by binding to sialoglycan ligands expressed on cancer cells, enabling them to ...
Karuppiah Muthumani, Mohamed Abdel-Mohsen, Hyeree Choi   +2 more
exaly   +3 more sources

Sialic acid cis-ligand dynamics modulate Siglec-7 and -9 function and affect Siglec-7/9 co-blockade to potentiate natural killer cell anti-tumor activity [PDF]

OncoImmunology
The glyco-immune checkpoints Siglec-7 and Siglec-9 have received considerable interest as targets for cancer immunotherapy. How Siglec-7/9-sialic acid cis-interactions on immune cells influence trans-signaling induced by tumor cells and whether Siglec-7 ...
Jesper van Eck van der Sluijs, Anne H. C. Valk, Eline J. H. van Houtum, Esther D. Kers-Rebel, Maaike Looman, Willemijn Hobo, Anna E. Marneth, Harry Dolstra, Lune van den Boogaard, Christian Büll, Lenneke A. M. Cornelissen, Gosse J. Adema   +11 more
doaj   +2 more sources

Siglec-9 defines and restrains a natural killer subpopulation highly cytotoxic to HIV-infected cells.

PLoS Pathogens, 2021
Siglec-9 is an MHC-independent inhibitory receptor expressed on a subset of natural killer (NK) cells. Siglec-9 restrains NK cytotoxicity by binding to sialoglycans (sialic acid-containing glycans) on target cells.
Opeyemi S Adeniji, Leticia Kuri-Cervantes, Chenfei Yu, Ziyang Xu, Michelle Ho, Glen M Chew, Cecilia Shikuma, Costin Tomescu, Ashley F George, Nadia R Roan, Lishomwa C Ndhlovu, Qin Liu, Kar Muthumani, David B Weiner, Michael R Betts, Han Xiao, Mohamed Abdel-Mohsen   +16 more
doaj   +2 more sources

Increase of intestinal bacterial sialidase activity exacerbates acute colitis in mice

Frontiers in Molecular Biosciences, 2022
The availability of endogenous and dietary carbohydrates in the gastrointestinal tract influences the composition of the gut microbiota. Carbohydrate foraging requires the action of bacterially-encoded glycoside hydrolases, which release mono- and ...
Tobias Hasler, Leticia Tavares-Gomes, Sereina Gut, Meghna Swayambhu, Mario Gysi, Martin Hausmann, Natasha Arora, Thierry Hennet   +7 more
doaj   +1 more source

Non-spatial and spatial heterogeneity revealed a suppressive immune feature of Siglec-15 in lung adenocarcinomas

Journal of Translational Medicine, 2023
Background Sialic acid-binding immunoglobulin-like lectin-15 (Siglec-15) has emerged as a novel immunotherapy candidate, which deserves a comprehensive investigation in lung adenocarcinoma (LUAD). Methods Multiplex fluorescence‐based immunohistochemistry
Baihui Li, Yan Guo, Yeran Yi, Ziqi Huang, Yulin Ren, Hao Wang, Lili Yang   +6 more
doaj   +1 more source

Mechanisms of Siglec-F-induced eosinophil apoptosis: a role for caspases but not for SHP-1, Src kinases, NADPH oxidase or reactive oxygen. [PDF]

PLoS ONE, 2013
BackgroundSiglec-F and Siglec-8 are functional paralog proapoptotic cell surface receptors expressed on mouse and human eosinophils, respectively. Whereas Siglec-8 mediated death involves caspases and/or reactive oxygen species (ROS) generation and ...
Hui Mao, Gen Kano, Sherry A Hudson, Mary Brummet, Nives Zimmermann, Zhou Zhu, Bruce S Bochner   +6 more
doaj   +1 more source

Immuno-PET Imaging of Siglec-15 Using the Zirconium-89-Labeled Therapeutic Antibody, NC318

Molecular Imaging, 2023
Objective. Sialic acid-binding immunoglobulin-like lectin 15 (Siglec-15) is overexpressed in various cancers which has led to the development of therapeutic anti-Siglec-15 monoconal antibodies (mAbs).
Elaine M. Jagoda, Falguni Basuli, Colleen Olkowski, Ido Weiss, Tim E. Phelps, Karen Wong, Anita Thien Ton, Kelly C. Lane, Steve Adler, Donna Butcher, Elijah F. Edmondson, Sol Langermann, Peter L. Choyke   +12 more
doaj   +1 more source

Siglec-9+ tumor-associated macrophages delineate an immunosuppressive subset with therapeutic vulnerability in patients with high-grade serous ovarian cancer

Journal for ImmunoTherapy of Cancer, 2023
Background The potent immunosuppressive properties of sialic acid-binding immunoglobulin-like lectin-9 (Siglec-9) on myeloid cells and lymphocytes provide a strong rationale for serving as a therapeutic target.
Yan Huang, Chen Zhang, Wei Jiang, Moran Yang, Guodong Zhang, Yiying Wang, Mengdi He, Haiou Liu, Kankan Cao   +8 more
doaj   +1 more source