Results 11 to 20 of about 15,861 (227)

Molecular cloning of porcine Siglec-3, Siglec-5 and Siglec-10, and identification of Siglec-10 as an alternative receptor for porcine reproductive and respiratory syndrome virus (PRRSV) [PDF]

Journal of General Virology, 2017
In recent years, several entry mediators have been characterized for porcine reproductive and respiratory syndrome virus (PRRSV). Porcine sialoadhesin [pSn, also known as sialic acid-binding immunoglobulin-type lectin (Siglec-1)] and porcine CD163 ...
Jiexiong Xie, Xie, Jiexiong, Nauwynck, Hans, Van Breedam, Wander, Bo Yang, Tingting Cui, Yang, Bo, Wander Van Breedam, Cui, Tingting, Hans J. Nauwynck, Christiaens, Isaura, Isaura Christiaens   +11 more
core   +3 more sources

Coevolution of Siglec-11 and Siglec-16 via gene conversion in primates [PDF]

BMC Evolutionary Biology, 2017
Background Siglecs-11 and -16 are members of the sialic acid recognizing Ig-like lectin family, and expressed in same cells. Siglec-11 functions as an inhibitory receptor, whereas Siglec-16 exhibits activating properties. In humans, SIGLEC11 and SIGLEC16
Liang, Suh-Yuen, Schwarz, Flavio, Chen, Xi, Fujito, Naoko T, Satta, Yoko, Angata, Takashi, Corinna Landig, Landig, Corinna, Hai Yu, Xi Chen, Takashi Angata, Varki, Ajit, Zahra Khedri, Yoko Satta, Yu, Hai, Hayakawa, Toshiyuki, Toshiyuki Hayakawa, Khedri, Zahra, Flavio Schwarz, Ajit Varki, Naoko T. Fujito, Suh-Yuen Liang   +21 more
core   +7 more sources

Siglec‐7 and Siglec‐9 expression in primary triple negative and oestrogen receptor positive breast cancer and in vitro signalling

Clinical & Translational Immunology
Objectives PD‐1/PD‐L1 immune checkpoint blockade can be an effective treatment for advanced breast cancer patients. However, patients with oestrogen receptor positive (ER+) tumors often display only low lymphocyte infiltration, while a large part of ...
Eline JH van Houtum, Anne HC Valk, Daniel Granado, Jasper Lok, Lune van den Bogaard, Naomi Remkes, Jesper van Eck van der Sluijs, Paul N Span, Lenneke AM Cornelissen, Gosse J Adema   +9 more
doaj   +2 more sources

Multivalent Siglec ligands

Carbohydrate Research
Siglecs are proteins that play important biological roles, especially in the immune system. Intervention with Siglec recognition has potential for modulation of the immune system. Progress in the discovery of specific Siglec ligands combined with the use
Afd Chemical Biology and Drug Discovery, Chemical Biology and Drug Discovery, Pieters, Roland J.   +2 more
core   +3 more sources

Siglec Ligands [PDF]

Cells, 2021
A dense and diverse array of glycans on glycoproteins and glycolipids decorate all cell surfaces. In vertebrates, many of these carry sialic acid, in a variety of linkages and glycan contexts, as their outermost sugar moiety. Among their functions, glycans engage complementary glycan binding proteins (lectins) to regulate cell physiology.
Anabel Gonzalez-Gil, Ronald L. Schnaar
openaire   +3 more sources

Siglec-7 restores β-cell function and survival and reduces inflammation in pancreatic islets from patients with diabetes.

, 2017
Chronic inflammation plays a key role in both type 1 and type 2 diabetes. Cytokine and chemokine production within the islets in a diabetic milieu results in β-cell failure and diabetes progression.
G Dharmadhikari (21879041), NG Morgan (21853058), A Varki (21879047), K Stolz (21879044), K Maedler (21879056), M Hauke (20714723), S Kelm (21879053), E de Koning (21879050)   +7 more
core   +6 more sources

Evolution of Siglec-11 and Siglec-16 Genes in Hominins [PDF]

Molecular Biology and Evolution, 2012
We previously reported a human-specific gene conversion of SIGLEC11 by an adjacent paralogous pseudogene (SIGLEC16P), generating a uniquely human form of the Siglec-11 protein, which is expressed in the human brain. Here, we show that Siglec-11 is expressed exclusively in microglia in all human brains studied-a finding of potential relevance to brain ...
Xiaoxia, Wang, Nivedita, Mitra, Pedro, Cruz, Liwen, Deng, Nissi, Varki, Takashi, Angata, Eric D, Green, Jim, Mullikin, Toshiyuki, Hayakawa, Ajit, Varki   +9 more
openaire   +2 more sources

The Inhibitory Receptor Siglec-8 Interacts With FcεRI and Globally Inhibits Intracellular Signaling in Primary Mast Cells Upon Activation

Frontiers in Immunology, 2022
Immunomodulation of mast cell (MC) activity is warranted in allergic and inflammatory diseases where MCs have a central role in pathogenesis. Targeting Siglec-8, an inhibitory receptor on MCs and eosinophils, has shown promising activity in preclinical ...
Wouter Korver, Alan Wong, Simon Gebremeskel, Gian Luca Negri, Julia Schanin, Katherine Chang, John Leung, Zachary Benet, Thuy Luu, Emily C. Brock, Kenneth Luehrsen, Alan Xu, Bradford A. Youngblood   +12 more
doaj   +1 more source

Siglec-6 mediates the uptake of extracellular vesicles through a noncanonical glycolipid binding pocket

Nature Communications, 2023
Immunomodulatory Siglecs are controlled by their glycoprotein and glycolipid ligands. Siglec-glycolipid interactions are often studied outside the context of a lipid bilayer, missing the complex behaviors of glycolipids in a membrane.
Edward N. Schmidt, Dimitra Lamprinaki, Kelli A. McCord, Maju Joe, Mirat Sojitra, Ayk Waldow, Jasmine Nguyen, John Monyror, Elena N. Kitova, Fahima Mozaneh, Xue Yan Guo, Jaesoo Jung, Jhon R. Enterina, Gour C. Daskhan, Ling Han, Amanda R. Krysler, Christopher R. Cromwell, Basil P. Hubbard, Lori J. West, Marianne Kulka, Simonetta Sipione, John S. Klassen, Ratmir Derda, Todd L. Lowary, Lara K. Mahal, Meghan R. Riddell, Matthew S. Macauley   +26 more
doaj   +1 more source

Siglec-E retards atherosclerosis by inhibiting CD36-mediated foam cell formation

Journal of Biomedical Science, 2021
Background The accumulation of lipid-laden macrophages, foam cells, within sub-endothelial intima is a key feature of early atherosclerosis. Siglec-E, a mouse orthologue of human Siglec-9, is a sialic acid binding lectin predominantly expressed on the ...
Yaw-Wen Hsu, Fu-Fei Hsu, Ming-Tsai Chiang, Dong-Lin Tsai, Fu-An Li, Takashi Angata, Paul R. Crocker, Lee-Young Chau   +7 more
doaj   +1 more source