Results 41 to 50 of about 15,861 (227)
Protein O-Glycosylation Shapes Lymphatic Endothelia and Lymph Node Macrophage Populations. [PDF]
FASEB JTo study the functional roles of O‐glycans on lymphatic endothelia, we deleted Cosmc, the chaperone required for core‐1 O‐glycan synthesis. Loss of core‐1 O‐glycans entailed major changes in glycoprotein composition of lymphatic endothelial cells (LEC), including reduced podoplanin (Pdpn), CD44, and Lyve‐1, and increased ICAM‐1; reduced CD44 was caused
Frey J +11 more
europepmc +2 more sources
Angewandte Chemie, EarlyView.Modular carbohydrate‐directed labeling probes (CDLPs) convert weak carbohydrate–protein interactions into durable covalent tags in live cells without the need for multivalency or UV irradiation. Ligand binding triggers proximity‐enabled, glycan‐releasing acyl transfer to install a click handle for protein tagging and chemoproteomic profiling.
Matthew C. Russolillo +7 more
wiley +2 more sources
Absence of Siglec-H in MCMV infection elevates interferon alpha production but does not enhance viral clearance. [PDF]
PLoS Pathogens, 2013 Plasmacytoid dendritic cells (pDCs) express the I-type lectin receptor Siglec-H and produce interferon α (IFNα), a critical anti-viral cytokine during the acute phase of murine cytomegalovirus (MCMV) infection.
Franz Puttur +14 more
doaj +1 more source
Siglec-15: a potential regulator of osteoporosis, cancer, and infectious diseases
Journal of Biomedical Science, 2020 Siglec-15 is a member of the Siglec family of glycan-recognition proteins, primarily expressed on a subset of myeloid cells. Siglec-15 has been known to be involved in osteoclast differentiation, and is considered to be a potential therapeutic target for
Takashi Angata
doaj +1 more source
Modulation of Immune Cell Reactivity with Cis-Binding Siglec Agonist [PDF]
, 2020 Primary inflammatory pathologies caused by phagocytes lead to numerous debilitating conditions, including chronic pain and blindness due to age-related macular degeneration.
Corleone, Delaveris +3 more
core +1 more source
, 2020 Pseudomonas aeruginosa (PA) is commonly associated with nosocomial and chronic infections of lungs. We have earlier demonstrated that an acidic sugar, sialic acid, is present in PA which is recognized and bound by sialic acid binding immunoglobulin type ...
Chitra Mandal (148111) +2 more
core +1 more source
Siglecs as Therapeutic Targets in Cancer
Biology, 2021 Hypersialylation is a common post-translational modification of protein and lipids found on cancer cell surfaces, which participate in cell-cell interactions and in the regulation of immune responses. Sialic acids are a family of nine-carbon α-keto acids found at the outermost ends of glycans attached to cell surfaces.
Jackwee Lim, Duygu Sari-Ak, Tanaya Bagga
openaire +4 more sources
Frontiers in Immunology, 2019 Natural Killer (NK) cells are cytotoxic lymphocytes that play a key role in the immune system, targeting and destroying invading pathogens and malignantly transformed cells.
John Daly +2 more
doaj +1 more source
, 2021 (A) A schematic representation of the workflow to evaluate the cytotoxic potential of NK cells against autologous HIV-infected CD4+ T cells in the presence of Siglec-9 antibody. CD4+ T cells were isolated from fresh PBMC and exposed to HIV-1 for 72 h. On
Han Xiao (373894) +16 more
core +1 more source
Respiratory Research, 2010 Background In this study we examined the role of Siglec-F, a receptor highly expressed on eosinophils, in contributing to mucus expression, airway remodeling, and Siglec-F ligand expression utilizing Siglec-F deficient mice exposed to chronic allergen ...
Doherty Taylor A +8 more
doaj +1 more source