Results 31 to 40 of about 15,861 (227)

Siglec-9⁺ CD56^dim cells exhibit lower cytotoxicity towards K562 cancer cells compared to Siglec-9^- CD56^dim.

, 2021
Cytotoxicity was assessed using NK degranulation and IFNγ production (E: T = 4:1). Total NK cells were gated on Siglec-9+ or Siglec-9- CD56dim NK cell subsets.
Han Xiao (373894), Opeyemi S. Adeniji (11682034), Ziyang Xu (1322553), Glen M. Chew (7122281), Costin Tomescu (606955), Ashley F. George (11682037), Mohamed Abdel-Mohsen (283492), Leticia Kuri-Cervantes (7382828), Chenfei Yu (1586326), Lishomwa C. Ndhlovu (7122293), David B. Weiner (9579320), Michelle Ho (6311882), Qin Liu (59805), Michael R. Betts (11682040), Nadia R. Roan (1320618), Kar Muthumani (504713), Cecilia Shikuma (22963)   +16 more
core   +1 more source

Exposure of Keratinocytes to Candida Albicans in the Context of Atopic Milieu Induces Changes in the Surface Glycosylation Pattern of Small Extracellular Vesicles to Enhance Their Propensity to Interact With Inhibitory Siglec Receptors

Frontiers in Immunology, 2022
Candida albicans (C. albicans) infection is a potential complication in the individuals with atopic dermatitis (AD) and can affect clinical course of the disease.
Adrian Kobiela, Joanna E. Frackowiak, Anna Biernacka, Lilit Hovhannisyan, Aleksandra E. Bogucka, Kinga Panek, Argho Aninda Paul, Joanna Lukomska, Xinwen Wang, Xinwen Wang, Eleni Giannoulatou, Aleksandra Krolicka, Jacek Zielinski, Milena Deptula, Milena Deptula, Michal Pikula, Susanne Gabrielsson, Susanne Gabrielsson, Graham S. Ogg, Danuta Gutowska-Owsiak, Danuta Gutowska-Owsiak   +20 more
doaj   +1 more source

Multivalent Ligands for Siglecs [PDF]

, 2010
Siglecs have emerged as an important family of immunomodulatory glycan-binding proteins that can bind sialoside ligands both on the same cell surface, in cis, and on other cells, in trans. Expression of siglecs varies among a variety of immune cells, and tools to probe siglecs on these cells are crucial to understanding their function.
Mary K, O'Reilly, James C, Paulson
openaire   +2 more sources

Siglec Signaling in the Tumor Microenvironment [PDF]

Frontiers in Immunology, 2021
Sialic acid-binding immunoglobulin-like lectins (Siglecs) are a family of receptors that recognize sialoglycans – sialic acid containing glycans that are abundantly present on cell membranes. Siglecs are expressed on most immune cells and can modulate their activity and function.
Eline J. H. van Houtum, Christian Büll, Christian Büll, Lenneke A. M. Cornelissen, Gosse J. Adema   +4 more
openaire   +7 more sources

Siglec functions of microglia [PDF]

Glycobiology, 2014
Microglia are the resident immune cells of the central nervous system. They can sense intact or lesioned cells and then respond in an appropriate way. Therefore, microglia need recognition receptors that lead to either the activation or the inhibition of the immune response pathways.
Bettina, Linnartz-Gerlach, Jens, Kopatz, Harald, Neumann   +2 more
openaire   +2 more sources

Expression of Siglec-E Alters the Proteome of Lipopolysaccharide (LPS)-Activated Macrophages but Does Not Affect LPS-Driven Cytokine Production or Toll-Like Receptor 4 Endocytosis

Frontiers in Immunology, 2018
Siglec-E is a murine CD33-related siglec that functions as an inhibitory receptor and is expressed mainly on neutrophils and macrophage populations. Recent studies have suggested that siglec-E is an important negative regulator of lipopolysaccharide (LPS)
Manjula Nagala, Emma McKenzie, Hannah Richards, Ritu Sharma, Sarah Thomson, Pietro Mastroeni, Paul R. Crocker   +6 more
doaj   +1 more source

Dynamic change in Siglec-15 expression in peritumoral macrophages confers an immunosuppressive microenvironment and poor outcome in glioma

Frontiers in Immunology, 2023
BackgroundSialic acid-binding immunoglobulin-like lectin-15 (Siglec-15) was reported to be a novel immune checkpoint molecule comparable to programmed cell death 1 ligand 1 (PD-L1).
Quan Chen, Quan Chen, Bingkun Chen, Bingkun Chen, Chunhua Wang, Li Hu, Qiongwen Wu, Yanyang Zhu, Qiuyu Zhang, Qiuyu Zhang   +9 more
doaj   +1 more source

Siglecs in the immune system [PDF]

Immunology, 2001
Siglecs1 (sialic acid binding Ig-like lectins) are I-type (Ig-type) lectins2 characterized by an N-terminal V-set Ig domain that mediates sialic acid binding,3 followed by varying numbers of C2-set Ig domains (Fig. 1). The initial discovery of this lectin family came about through independent studies on sialoadhesin (Siglec-1/CD169), a macrophage ...
P R, Crocker, A, Varki
openaire   +2 more sources

Tumor Derived SIGLEC Family Genes May Play Roles in Tumor Genesis, Progression, and Immune Microenvironment Regulation

Frontiers in Oncology, 2020
BackgroundSIGLEC family genes can also be expressed on tumor cells in different cancer types, and though it has been found that SIGLEC genes expressed by immune cells can be exploited by tumors to escape immune surveillance, functions of tumor derived ...
Zheng Chen, Mincheng Yu, Lei Guo, Bo Zhang, Shuang Liu, Wentao Zhang, Binghai Zhou, Jiuliang Yan, Qianni Ma, Zhangfu Yang, Yongsheng Xiao, Yongfeng Xu, Hui Li, Qinghai Ye   +13 more
doaj   +1 more source

Significance of Siglec‐15 expression in colorectal cancer: association with advanced disease stage and fewer tumor‐infiltrating lymphocytes

The Journal of Pathology: Clinical Research, 2023
Siglec‐15, a novel immune suppressor, is upregulated in many human cancers. The aim of this study was to explore the expression of Siglec‐15 in colorectal cancer (CRC), and investigate whether Siglec‐15 could be a potential target for cancer ...
Zhao Lu, Pu Cheng, Fei Huang, Jiyun Li, Bingzhi Wang, Shuangmei Zou, Zhaoxu Zheng, Chunwei Peng   +7 more
doaj   +1 more source