Results 1 to 10 of about 6,019,441 (302)

Sialic Acid Mimetics to Target the Sialic Acid-Siglec Axis.

Trends in Biochemical Sciences, 2016
Sialic acid sugars are vital regulators of the immune system through binding to immunosuppressive sialic acid-binding immunoglobulin-like lectin (Siglec) receptors on immune cells. Aberrant sialic acid-Siglec interactions are associated with an increasing number of pathologies including infection, autoimmunity, and cancer.
C. Büll, T. Heise, G. Adema, T. Boltje
semanticscholar   +6 more sources

Influence of Host Sialic Acid Receptors Structure on the Host Specificity of Influenza Viruses

Viruses, 2022
Influenza viruses need to use sialic acid receptors to invade host cells, and the α-2,3 and α-2,6 sialic acids glycosidic bonds linking the terminal sialic acids are generally considered to be the most important factors influencing the cross-species ...
Chuankuo Zhao, Juan Pu
doaj   +2 more sources

Sialic Acid Metabolism: A Key Player in Breast Cancer Metastasis Revealed by Metabolomics

Frontiers in Oncology, 2018
Metastatic breast cancer is currently incurable. It has recently emerged that different metabolic pathways support metastatic breast cancer. To further uncover metabolic pathways enabling breast cancer metastasis, we investigated metabolic differences in
Shao Thing Teoh, Martin P. Ogrodzinski, Martin P. Ogrodzinski, Christina Ross, Kent W. Hunter, Sophia Y. Lunt, Sophia Y. Lunt   +6 more
doaj   +2 more sources

Sialic acid glycoengineering using N-acetylmannosamine and sialic acid analogs.

Glycobiology, 2019
Sialic acids cap the glycans of cell surface glycoproteins and glycolipids. They are involved in a multitude of biological processes and aberrant sialic acid expression is associated with several pathologies. Sialic acids modulate the characteristics and
S. Moons, G. Adema, Max T. G. M. Derks, T. Boltje, C. Büll   +4 more
semanticscholar   +4 more sources

Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+ site

Nature Communications, 2018
Sialic acid transporters (SiaT) are required for sialic acid uptake in a number of human pathogens and are of interest as targets for antimicrobial drug development. Here the authors present the substrate bound SiaT structure from the uropathogen Proteus
Weixiao Y. Wahlgren, Elin Dunevall, Rachel A. North, Aviv Paz, Mariafrancesca Scalise, Paola Bisignano, Johan Bengtsson-Palme, Parveen Goyal, Elin Claesson, Rhawnie Caing-Carlsson, Rebecka Andersson, Konstantinos Beis, Ulf J. Nilsson, Anne Farewell, Lorena Pochini, Cesare Indiveri, Michael Grabe, Renwick C. J. Dobson, Jeff Abramson, S. Ramaswamy, Rosmarie Friemann   +20 more
doaj   +2 more sources

SIAE-Mediated Loss of Sialic Acid Acetylation Contributes to Ulcerative Colitis [PDF]

Journal of Inflammation Research
Siyue Bo,1,* Xiaotong Wang,1– 3,* Jiani Qian,1,4 Guoqiang Ma,5 Zheng Ying,5 Duanmin Hu,2 Chunyan Hou,6 Junfeng Ma,6 Longjiang Xu,4 Shuang Yang1,7,8 1Center for Clinical Mass Spectrometry, College of Pharmaceutical Sciences, Soochow University ...
Bo S, Wang X, Qian J, Ma G, Ying Z, Hu D, Hou C, Ma J, Xu L, Yang S   +9 more
doaj   +2 more sources

Biochemical and structural basis of sialic acid utilization by gut microbes

Journal of Biological Chemistry, 2023
The human gastrointestinal (GI) tract harbors diverse microbial communities collectively known as the gut microbiota that exert a profound impact on human health and disease.
Andrew Bell, E. Severi, C. Owen, D. Latousakis, N. Juge   +4 more
semanticscholar   +1 more source

Concentration and distribution of sialic acid in human milk and its correlation with dietary intake

Frontiers in Nutrition, 2022
PurposeThis study evaluates the content, distribution, and changing trend of sialic acid in human milk and the correlation between dietary intake of sialic acid and that in human milk.MethodsThe study included 33 mothers of full-term and exclusively ...
Qiaoling Xie, Yuhan Xu, Wei Zhang, Meizhen Zhu, Xinyue Wang, Jiale Huang, Yingying Zhuang, Hui Lan, Xiaoxuan Chen, Dongbei Guo, Hongwei Li   +10 more
doaj   +1 more source

Targeting the Siglec–Sialic Acid Immune Axis in Cancer: Current and Future Approaches

Cancer immunology research, 2022
The sialic acid–binding immunoglobulin-like lectin (Siglec)–sialic acid immune axis is an evolutionarily conserved immunoregulatory pathway that provides a mechanism for establishing self-recognition and combatting invasive pathogens.
H. Läubli, Sam C. Nalle, D. Maslyar
semanticscholar   +1 more source

Sialic acid O-acetylation: From biosynthesis to roles in health and disease

Journal of Biological Chemistry, 2021
Sialic acids are nine-carbon sugars that frequently cap glycans at the cell surface in cells of vertebrates as well as cells of certain types of invertebrates and bacteria.
Eline A. Visser, S. Moons, S. P. Timmermans, Heleen de Jong, T. Boltje, C. Büll   +5 more
semanticscholar   +1 more source