Results 1 to 10 of about 59,691 (231)

Sialic Acid Mimetics to Target the Sialic Acid–Siglec Axis

Trends in Biochemical Sciences, 2016
Sialic acid sugars are vital regulators of the immune system through binding to immunosuppressive sialic acid-binding immunoglobulin-like lectin (Siglec) receptors on immune cells. Aberrant sialic acid-Siglec interactions are associated with an increasing number of pathologies including infection, autoimmunity, and cancer.
Christian Bull, Thomas Boltje, Gosse J Adema   +2 more
exaly   +4 more sources

SIAE-Mediated Loss of Sialic Acid Acetylation Contributes to Ulcerative Colitis [PDF]

Journal of Inflammation Research
Siyue Bo,1,* Xiaotong Wang,1– 3,* Jiani Qian,1,4 Guoqiang Ma,5 Zheng Ying,5 Duanmin Hu,2 Chunyan Hou,6 Junfeng Ma,6 Longjiang Xu,4 Shuang Yang1,7,8 1Center for Clinical Mass Spectrometry, College of Pharmaceutical Sciences, Soochow University ...
Bo S, Wang X, Qian J, Ma G, Ying Z, Hu D, Hou C, Ma J, Xu L, Yang S   +9 more
doaj   +2 more sources

Concentration and distribution of sialic acid in human milk and its correlation with dietary intake

Frontiers in Nutrition, 2022
PurposeThis study evaluates the content, distribution, and changing trend of sialic acid in human milk and the correlation between dietary intake of sialic acid and that in human milk.MethodsThe study included 33 mothers of full-term and exclusively ...
Qiaoling Xie, Yuhan Xu, Wei Zhang, Meizhen Zhu, Xinyue Wang, Jiale Huang, Yingying Zhuang, Hui Lan, Xiaoxuan Chen, Dongbei Guo, Hongwei Li   +10 more
doaj   +1 more source

Sialic acid utilisation and synthesis in the neonatal rat revisited. [PDF]

PLoS ONE, 2009
BACKGROUND:Milk is the sole source of nutrients for neonatal mammals and is generally considered to have co-evolved with the developmental needs of the suckling newborn.
Peter I Duncan, Frédéric Raymond, Andreas Fuerholz, Norbert Sprenger   +3 more
doaj   +1 more source

Influence of Host Sialic Acid Receptors Structure on the Host Specificity of Influenza Viruses

Viruses, 2022
Influenza viruses need to use sialic acid receptors to invade host cells, and the α-2,3 and α-2,6 sialic acids glycosidic bonds linking the terminal sialic acids are generally considered to be the most important factors influencing the cross-species ...
Chuankuo Zhao, Juan Pu
doaj   +1 more source

Usefulness of sialic acid for diagnosis of sepsis in critically ill patients: a retrospective study

BMC Anesthesiology, 2020
Background Early diagnosis of sepsis is very important. It is necessary to find effective and adequate biomarkers in order to diagnose sepsis. In this study, we compared the value of sialic acid and procalcitonin for diagnosing sepsis.
Bo Yao, Wen-juan Liu, Di Liu, Jin-yan Xing, Li-juan Zhang   +4 more
doaj   +1 more source

Sialic Acid Utilization [PDF]

Advances in Nutrition, 2012
Early postnatal development encounters milk as a key environmental variable and yet the sole nutrient source. One evolutionary conserved constituent of milk is sialic acid, which is generally displayed on glycoconjugates and free glycans. During early postnatal development, high sialic acid need was proposed to be unmet by the endogenous sialic acid ...
Norbert, Sprenger, Peter I, Duncan
openaire   +2 more sources

Synthesis of Sialic Acids and Sialic Acid Derivatives [PDF]

, 1982
Sialic acids as such, sialic acid derivatives, analogues, glycosides and sialooligosaccharides have been subject of many synthetic investigations. These studies were aimed at a further exploration of the properties of sialic acids, the preparation of substrates and inhibitors for sialidases, sialyltransferases or for sialic acid converting enzymes, and
Vliegenthart, J.F.G., Kamerling, J.P.
openaire   +2 more sources

SIALIC ACID VALUE IN PLEURAL EFFUSION AS A DIAGNOSTIC MARKER OF MALIGNANCY [PDF]

Journal of the Egyptian Society of Parasitology, 2013
In differential diagnosis of pleural effusions, cytology is the most sensitive method. Since cytology findings are positive in half of such fluids, combined use of reliable tumor marker and cytology is a logical approach.
SAMAR MARZOUK, SHERIF ALSAYED
doaj   +1 more source

Interferon-gamma inhibits influenza A virus cellular attachment by reducing sialic acid cluster size

iScience, 2022
Summary: The mucosal antiviral role of type I and III interferon in influenza virus infection is well established. However, much less is known about the antiviral mechanism of type II interferon (interferon-gamma).
Carol Ho-Yan Fong, Lu Lu, Lin-Lei Chen, Man-Lung Yeung, Anna Jinxia Zhang, Hanjun Zhao, Kwok-Yung Yuen, Kelvin Kai-Wang To   +7 more
doaj   +1 more source