Sialic acid utilisation and synthesis in the neonatal rat revisited. [PDF]
PLoS ONE, 2009 BACKGROUND:Milk is the sole source of nutrients for neonatal mammals and is generally considered to have co-evolved with the developmental needs of the suckling newborn.
Peter I Duncan +3 more
doaj +1 more source
Advances in Nutrition, 2012 Early postnatal development encounters milk as a key environmental variable and yet the sole nutrient source. One evolutionary conserved constituent of milk is sialic acid, which is generally displayed on glycoconjugates and free glycans. During early postnatal development, high sialic acid need was proposed to be unmet by the endogenous sialic acid ...
Norbert, Sprenger, Peter I, Duncan
openaire +2 more sources
Usefulness of sialic acid for diagnosis of sepsis in critically ill patients: a retrospective study
BMC Anesthesiology, 2020 Background Early diagnosis of sepsis is very important. It is necessary to find effective and adequate biomarkers in order to diagnose sepsis. In this study, we compared the value of sialic acid and procalcitonin for diagnosing sepsis.
Bo Yao +4 more
doaj +1 more source
Relationship between plasma sialic acid and fibinogen concentration and incident micro-and macrovascular complications in type 1 diabetes [PDF]
, 2008 AIMS/HYPOTHESIS: Type 1 diabetes is associated with an increased risk of vascular complications. This increased risk could be explained by sialic acid and/or fibrinogen.
CHATURVEDI N +5 more
core +9 more sources
Interferon-gamma inhibits influenza A virus cellular attachment by reducing sialic acid cluster size
iScience, 2022 Summary: The mucosal antiviral role of type I and III interferon in influenza virus infection is well established. However, much less is known about the antiviral mechanism of type II interferon (interferon-gamma).
Carol Ho-Yan Fong +7 more
doaj +1 more source
Synthesis of Sialic Acids and Sialic Acid Derivatives [PDF]
, 1982 Sialic acids as such, sialic acid derivatives, analogues, glycosides and sialooligosaccharides have been subject of many synthetic investigations. These studies were aimed at a further exploration of the properties of sialic acids, the preparation of substrates and inhibitors for sialidases, sialyltransferases or for sialic acid converting enzymes, and
Vliegenthart, J.F.G., Kamerling, J.P.
openaire +2 more sources
NANS-mediated synthesis of sialic acid is required for brain and skeletal development
Nature Genetics, 2016 C. V. van Karnebeek +45 more
semanticscholar +3 more sources
Implication of Sialidases in Salmonella Infection: Genome Release of Sialidase Knockout Strains from Salmonella enterica Serovar Typhimurium LT2. [PDF]
, 2017 Sialidases, which are widely distributed in nature, cleave the α-ketosidic bond of terminal sialic acid residue. These emerging virulence factors degrade the host glycan.
Arabyan, Narine +3 more
core +2 more sources
Ferrets exclusively synthesize Neu5Ac and express naturally humanized influenza A virus receptors [PDF]
, 2014 Mammals express the sialic acids N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc) on cell surfaces, where they act as receptors for pathogens, including influenza A virus (IAV). Neu5Gc is synthesized from Neu5Ac by the enzyme
Böhm, Raphael +14 more
core +1 more source
Increased expression of sialic acid in cervical biopsies with squamous intraepithelial lesions
Diagnostic Pathology, 2010 Background Altered sialylation has been observed during oncogenic transformation. Sialylated oligosaccharides of glycoproteins and glycolipids have been implicated in tumor progression and metastases.
Vallejo-Ruiz Verónica +4 more
doaj +1 more source