Results 21 to 30 of about 59,691 (231)

The Effect of Sialic Acid on MiR-320a and Let-7e Expression in Human Glial Cell Line

Basic and Clinical Neuroscience, 2022
Introduction: Sialic acid is pivotal in various critical physiological events at molecular and cellular levels and pathological processes. Changes in sialic acid concentration are observed in many pathological processes; for example, some available data ...
Negar Noorbakhsh, Hamid Galehdari, Mohammad Shafiei   +2 more
doaj  

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

Cell surface α2,3-linked sialic acid facilitates Zika virus internalization

Emerging Microbes and Infections, 2019
The emergence of neurotropic Zika virus (ZIKV) raised a public health emergency of global concern. ZIKV can cross the placental barrier and infect foetal brains, resulting in microcephaly, but the pathogenesis of ZIKV is poorly understood.
Chee Wah Tan, Catherine Hong Huan Hor, Swee Sen Kwek, Han Kang Tee, I-Ching Sam, Eyleen L. K. Goh, Eng Eong Ooi, Yoke Fun Chan, Lin-Fa Wang   +8 more
doaj   +1 more source

Predictive Value of Serum Sialic Acid in Type-2 Diabetes Mellitus and Its Complication (Nephropathy) [PDF]

Journal of Clinical and Diagnostic Research, 2013
Introduction: Sialic acid levels are increased in type-2 diabetes mellitus and its estimation helps in predicting the occurrence of microvascular complication such as diabetic nephropathy. The present study compared the levels of sialic acid, glycated
Prajna K., Ashok Kumar J., Srinidhi Rai, Shobith Kumar Shetty, Tirthal Rai, Shrinidhi, Mohamedi Begum, Shashikala MD   +7 more
doaj   +1 more source

The Potential Use of Sialic Acid From Edible Bird’s Nest to Attenuate Mitochondrial Dysfunction by In Vitro Study

Frontiers in Pharmacology, 2021
Edible bird’s nest (EBN) is one of the expensive functional foods in herbal medicine. One of the major glyconutrients in EBN is sialic acid, which has a beneficial effect on neurological and intellectual capability in mammals.
Aswir Abd Rashed, Hafandi Ahmad, Siti Khadijah Abdul Khalid, Devi-Nair Gunasegavan Rathi   +3 more
doaj   +1 more source

Sialic acid content of low density lipoprotein and its relation to lipid concentrations and metabolism of low density lipoprotein and cholesterol

Journal of Lipid Research, 2000
A low sialic acid content in low density lipoprotein (LDL) has been associated with atherogenicity and coronary artery disease (CAD) in many but not all studies. We investigated associations of the sialic acid-to-apolipoprotein B (apoB) ratio of LDL with
Nina Lindbohm, Helena Gylling, Tatu A. Miettinen   +2 more
doaj   +1 more source

N-acetylneuraminic acid: A scrutinizing tool in oral squamous cell carcinoma diagnosis

Dental Research Journal, 2017
Background: Oral cancer has one of the highest mortality rate among other malignancies. An attempt has been made to assess the genetic expression of a cell surface glycoprotein component - sialic acid released by the malignant cells which will reflect on
Suganya Rajaram, Balamurali P Danasekaran, Ramesh Venkatachalapathy, Karthikshree Vishnu Prashad, Saranya Rajaram   +4 more
doaj   +1 more source

Glycosidation of sialic acid.

Journal of Synthetic Organic Chemistry, Japan, 1989
N-Acetylneuraminic acid (Neu5Ac), a typical sialic acid, located at the non-reducing ends of carbohydrate chains of glycoproteins and glycolipids plays an important role in biological phenomena. The synthesis of oligosaccharides which contain Neu5Ac has focused with clarification of their vital functions.
OKAMOTO, Kaoru, GOTO, Toshio
openaire   +2 more sources

The Sodium Sialic Acid Symporter From Staphylococcus aureus Has Altered Substrate Specificity

Frontiers in Chemistry, 2018
Mammalian cell surfaces are decorated with complex glycoconjugates that terminate with negatively charged sialic acids. Commensal and pathogenic bacteria can use host-derived sialic acids for a competitive advantage, but require a functional sialic acid ...
Rachel A. North, Rachel A. North, Rachel A. North, Weixiao Y. Wahlgren, Weixiao Y. Wahlgren, Daniela M. Remus, Daniela M. Remus, Mariafrancesca Scalise, Sarah A. Kessans, Sarah A. Kessans, Elin Dunevall, Elin Claesson, Tatiana P. Soares da Costa, Matthew A. Perugini, S. Ramaswamy, Jane R. Allison, Jane R. Allison, Jane R. Allison, Cesare Indiveri, Rosmarie Friemann, Rosmarie Friemann, Renwick C. J. Dobson, Renwick C. J. Dobson   +22 more
doaj   +1 more source

Unraveling the impact of sialic acids on the immune landscape and immunotherapy efficacy in pancreatic cancer

Journal for ImmunoTherapy of Cancer, 2023
Background Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers. Despite the successful application of immune checkpoint blockade in a range of human cancers, immunotherapy in PDAC remains unsuccessful.
Manfred Wuhrer, Louis Boon, Di Wang, Yvette van Kooyk, Ernesto Rodriguez, Joke M M Den Haan, Nadine van Montfoort, Sandra J van Vliet, Kelly Boelaars, Laura Goossens-Kruijssen, Charlotte M de Winde, Dimitri Lindijer, Babet Springer, Irene van der Haar Àvila, Aram de Haas, Laetitia Wehry, Reina E Mebius   +16 more
doaj   +1 more source