Results 1 to 10 of about 1,000,988 (208)

Recent advances on N-acetylneuraminic acid: Physiological roles, applications, and biosynthesis [PDF]

Synthetic and Systems Biotechnology, 2023
N-Acetylneuraminic acid (Neu5Ac), the most common type of Sia, generally acts as the terminal sugar in cell surface glycans, glycoconjugates, oligosaccharides, lipo-oligosaccharides, and polysaccharides, thus exerting numerous physiological functions ...
Mingli Zhao, Yingying Zhu, Hao Wang, Wenli Zhang, Wanmeng Mu   +4 more
doaj   +3 more sources

Titrating bacterial growth and chemical biosynthesis for efficient N-acetylglucosamine and N-acetylneuraminic acid bioproduction [PDF]

Nature Communications, 2020
An imbalance between cell growth and bioproduction of engineered microbes often reduces production efficiency. Here, the authors report genetic code expansion-based cell growth and biosynthesis balance engineering to achieve high levels production of N ...
Rongzhen Tian, Yanfeng Liu, Yanting Cao, Zhongjie Zhang, Jianghua Li, Long Liu, Guocheng Du, Jian Chen   +7 more
doaj   +3 more sources

Many locks to one key: N-acetylneuraminic acid binding to proteins [PDF]

IUCrJ
Sialic acids play crucial roles in cell surface glycans of both eukaryotic and prokaryotic organisms, mediating various biological processes, including cell–cell interactions, development, immune response, oncogenesis and host–pathogen interactions. This
KanagaVijayan Dhanabalan, YiYang Cheng, Trung Thach, Ramaswamy Subramanian   +3 more
doaj   +3 more sources

Distinguishing N-acetylneuraminic acid linkage isomers on glycopeptides by ion mobility-mass spectrometry [PDF]

Chemical Communications, 2016
Differentiating the structure of isobaric glycopeptides represents a major challenge for mass spectrometry-based characterisation techniques. Here we show that the regiochemistry of the most common N-acetylneuraminic acid linkages of N-glycans can be ...
Altmann, F., Hinneburg, H., Hofmann, J., Kolarich, D., Pagel, K., Seeberger, P. H., Struwe, W. B., Thader, A., Varón Silva, D.   +8 more
core   +5 more sources

Identification of an N-acetylneuraminic acid-presenting bacteria isolated from a human microbiome [PDF]

Scientific Reports, 2021
N-Acetylneuraminic acid is the most abundant sialic acid (SA) in humans and is expressed as the terminal sugar on intestinal mucus glycans. Several pathogenic bacteria harvest and display host SA on their own surfaces to evade Siglec-mediated host ...
Zhen Han, Peter S. Thuy-Boun, Wayne Pfeiffer, Vincent F. Vartabedian, Ali Torkamani, John R. Teijaro, Dennis W. Wolan   +6 more
doaj   +3 more sources

Presence of N-acetylneuraminic acid in the lung during postnatal development [PDF]

European Journal of Histochemistry, 2020
Sialic acids, particularly N-acetylneuraminic acid (Neu5Ac), are present as terminal components of rich and complex oligosaccharide chains, which are termed glycans, and are exhibited on the cell surfaces, especially on epithelial cells.
Maria de Fátima Martins, Marco S. Freitas, Ana Honório-Ferreira, Carlos Alberto Gonçalves   +3 more
doaj   +4 more sources

A novel variant in CMAH is associated with blood type AB in Ragdoll cats [PDF]

PLoS ONE, 2016
The enzyme cytidine monophospho-N-acetylneuraminic acid hydroxylase is associated with the production of sialic acids on cat red blood cells. The cat has one major blood group with three serotypes; the most common blood type A being dominant to type B. A
Gandolfi, Barbara, Helps, Christopher R, Lyons, Leslie A   +2 more
core   +17 more sources

N-acetylneuraminic acid links immune exhaustion and accelerated memory deficit in diet-induced obese Alzheimer’s disease mouse model [PDF]

Nat Commun, 2023
Obesity and aging increase Alzheimer’s disease (AD) risk. Here, using an AD mouse model and high-fat diet, we suggest that immune exhaustion links the two risk factors, and identify a metabolite that can hasten immune dysfunction and memory deficit ...
Stefano Suzzi, T. Croese, Adi Ravid, Or Gold, Abbe R. Clark, S. Medina, D. Kitsberg, Miriam Adam, K. Vernon, Eva Kohnert, Inbar Shapira, S. Malitsky, M. Itkin, A. Brandis, Tevie Mehlman, T. Salame, Sarah P. Colaiuta, L. Cahalon, M. Slyper, A. Greka, Naomi Habib, Michal Schwartz   +21 more
semanticscholar   +2 more sources

Atlantic Salmon Mucins Inhibit LuxS-Dependent A. Salmonicida AI-2 Quorum Sensing in an N-Acetylneuraminic Acid-Dependent Manner [PDF]

Int J Mol Sci, 2022
One of the most important bacterial diseases in salmonid aquaculture is furunculosis, caused by Aeromonas salmonicida. Bacterial communication through secreted autoinducer signals, quorum sensing, takes part in the regulation of gene expression in ...
J. Padra, S. Loibman, Kaisa Thorell, H. Sundh, K. Sundell, Sara K. Lindén   +5 more
semanticscholar   +2 more sources

Correlation of Serum N-Acetylneuraminic Acid with the Risk of Moyamoya Disease [PDF]

Brain Sciences, 2023
N-acetylneuraminic acid (Neu5Ac) is a functional metabolite and has been demonstrated to be a risk factor for cardiovascular diseases. It is not clear whether Neu5Ac is associated with a higher risk of cerebrovascular disorders, especially moyamoya ...
Chenglong Liu, Peicong Ge, Chaofan Zeng, Xiaofan Yu, Yuanren Zhai, Wei Liu, Qiheng He, Junsheng Li, Xingju Liu, Jia Wang, Xun Ye, Qian Zhang, Rong Wang, Yan Zhang, Jizong Zhao, Dong Zhang   +15 more
doaj   +2 more sources