Results 1 to 10 of about 15,525,833 (178)
Structure of a Sialo-Oligosaccharide from Glycophorin in Carp Red Blood Cell Membranes
Membranes, 2014 We isolated a high-purity carp glycophorin from carp erythrocyte membranes and prepared the oligosaccharide fraction from glycophorin by β-elimination [1].
Takahiko Aoki +3 more
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Xenotransplantation, Volume 33, Issue 4, July/August 2026.ABSTRACT Xenotransplantation utilizing pig donors offers a promising solution to organ shortages, but immune incompatibilities across species remain a major challenge. Current reliance on porcine primary fibroblasts for genome editing is limited by low inefficiency in complex gene editing and difficulties in immunophenotyping edited cells.
Yiyi Xuan +4 more
wiley +1 more source
Isolation and characterization of the trisialogangliosides from bovine adrenal medulla
Journal of Lipid Research, 1983 Trisialogangliosides were isolated from bovine adrenal medulla by DEAE-Sephadex A-25 and Iatrobeads column chromatography. Their structures were elucidated by sugar analysis, neuraminidase digestion, and permethylation studies. The complete structures of
T Ariga, M Sekine, R K Yu, T Miyatake
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Current Status of Kidney Xenotransplantation in Basic Research
Organ Medicine, Volume 3, Issue 2, Page 87-101, June 2026.Kidney xenotransplantation is a potential solution to the organ shortage for end‐stage kidney disease. This review systematically elaborates on the application advances of donor pig gene editing technologies, the molecular mechanisms and regulatory strategies of xenogeneic immune rejection, and the optimization approaches of immune compatibility ...
Yu Luo, Bingzhuo Liu, Weijie Lai
wiley +1 more source
Environmental Microbiology, Volume 28, Issue 5, May 2026.The human gut outer mucus layer hosts specific microbes. Using a synthetic mucin glycan‐degrading microbial community to mimic this mucosal microbiome, we show that mucin type affects microbial community composition, glycan degradation and metabolite production.
Maryse D. Berkhout +5 more
wiley +1 more source
BiomoleculesN-Glycolylneuraminic acid (Neu5Gc) is a sialic acid variant commonly found in most mammals but not synthesized by humans due to an inactivating mutation in the CMP-Neu5Ac hydroxylase (CMAH) gene. Despite this, Neu5Gc-containing molecules are consistently
Rancés Blanco, Juan P. Muñoz
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Perinatal Gut Dysbiosis Reduces Milk Oligosaccharides via LPS‐Mediated Gut–Mammary Signaling in Mice
Food Frontiers, Volume 7, Issue 2, March 2026.Maternal gut dysbiosis elevates Gram‐negative bacterial lipopolysaccharide (LPS), which enters circulation and accumulates in mammary tissue. This compromises the blood–milk barrier and suppresses key enzymatic genes, ultimately reducing milk oligosaccharide synthesis and potentially affecting neonatal gut microbiota through breastfeeding.
Man‐Lin Zhou +9 more
wiley +1 more source
Molecular recognition of gangliosides and their potential for cancer immunotherapies
Frontiers in Immunology, 2014 Gangliosides are sialic acid-containing glycosphingolipids expressed on all vertebrate cells. They are primarily positioned in the plasma membrane, with the ceramide part anchored in the membrane and the glycan part exposed on the surface of the cell ...
Ute eKrengel, Paula A Bousquet
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Xenotransplantation, Volume 33, Issue 2, March/April 2026.ABSTRACT Background Severe thrombocytopenia and coagulation dysregulation remain major barriers to survival in pig‐to‐primate liver xenotransplantation models. Methods Porcine livers with five genetic modifications (GTKO, CMAHKO, β4GalNT2KO, hCD55, and hTBM) were orthotopically transplanted into four Tibetan macaques under two conventional ...
Zhongqiang Zhang +17 more
wiley +1 more source
Enzymatic Synthesis of Trideuterated Sialosides
Molecules, 2019 Sialic acids are a family of acidic monosaccharides often found on the termini of cell surface proteins or lipid glycoconjugates of higher animals. Herein we describe the enzymatic synthesis of the two isotopically labeled sialic acid derivatives d3-X ...
Zhi-P. Cai +11 more
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