Results 31 to 40 of about 15,525,833 (178)

Canine and feline parvoviruses preferentially recognize the non-human cell surface sialic acid N-glycolylneuraminic acid. [PDF]

Virology, 2013
Feline panleukopenia virus (FPV) is a pathogen whose canine-adapted form (canine parvovirus (CPV)) emerged in 1978. These viruses infect by binding host transferrin receptor type-1 (TfR), but also hemagglutinate erythrocytes.
Löfling J, Lyi SM, Parrish CR, Varki A.
europepmc   +2 more sources

Comparison of sialic acid content in bovine and buffalo milk and meat

Revista Científica, 2023
Animal-origin food, such as meat and milk, are important sources of sialic acids (SIAs) with relevant implications for human health. Two significant SIAs in mammals are N-acetyl-neuraminic acid (Neu5Ac) and N- glycolylneuraminic acid (Neu-5Gc).
Michela Contò, Simona Rinaldi, Sebastiana Failla   +2 more
doaj   +1 more source

Catalytic preference of Salmonella typhimurium LT2 sialidase for N-acetylneuraminic acid residues over N-glycolylneuraminic acid residues. [PDF]

FEBS Open Bio, 2013
In a comparison of sialidase activities toward N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc), we found that Salmonella typhimurium LT2 sialidase (STSA) hardly cleaved 4-methylumbelliferyl Neu5Gc (4MU-Neu5Gc).
Minami A, Ishibashi S, Ikeda K, Ishitsubo E, Hori T, Tokiwa H, Taguchi R, Ieno D, Otsubo T, Matsuda Y, Sai S, Inada M, Suzuki T.   +12 more
europepmc   +2 more sources

Generation of cattle knockout for galactose-α1,3-galactose and N-glycolylneuraminic acid antigens. [PDF]

Xenotransplantation, 2019
AbstractTwo well‐characterized carbohydrate epitopes are absent in humans but present in other mammals. These are galactose‐α1,3‐galactose (αGal) and N‐glycolylneuraminic acid (Neu5Gc) which are introduced by the activities of two enzymes including α(1,3) galactosyltransferase (encoded by the GGTA1 gene) and CMP‐Neu5Gc hydroxylase (encoded by the CMAH ...
Perota A, Lagutina I, Duchi R, Zanfrini E, Lazzari G, Judor JP, Conchon S, Bach JM, Bottio T, Gerosa G, Costa C, Galiñanes M, Roussel JC, Padler-Karavani V, Cozzi E, Soulillou JP, Galli C.   +16 more
europepmc   +8 more sources

A Novel Variant in CMAH Is Associated with Blood Type AB in Ragdoll Cats. [PDF]

PLoS ONE, 2016
The enzyme cytidine monophospho-N-acetylneuraminic acid hydroxylase is associated with the production of sialic acids on cat red blood cells. The cat has one major blood group with three serotypes; the most common blood type A being dominant to type B. A
Barbara Gandolfi, Robert A Grahn, Nicholas A Gustafson, Daniela Proverbio, Eva Spada, Badri Adhikari, Janling Cheng, Gordon Andrews, Leslie A Lyons, Chris R Helps   +9 more
doaj   +1 more source

Hydroxylation of N-acetylneuraminic Acid Influences the in vivo Tropism of N-linked Sialic Acid-Binding Adeno-Associated Viruses AAV1, AAV5, and AAV6

Frontiers in Medicine, 2021
Adeno-associated virus (AAV) vectors are promising candidates for gene therapy. However, a number of recent preclinical large animal studies failed to translate into the clinic. This illustrates the formidable challenge of choosing the animal models that
Estrella Lopez-Gordo, Alejandro Orlowski, Arthur Wang, Alan Weinberg, Susmita Sahoo, Thomas Weber, Thomas Weber   +6 more
doaj   +1 more source

Correction: Serological Assessment of Alpha Galactosidase, N-Glycolylneuraminic Acid, and Histopathological Observations in Xenograft Recipients. [PDF]

Cureus
Background and aims The alpha-galactosidase (αGal) epitope and the associated anti-Gal antibodies, along with the non-human sialic acid N-glycolylneuraminic acid (Neu5Gc) and its corresponding anti-Neu5Gc antibodies, represent critical obstacles in the field of xenotransplantation. We present an evaluation of serological and histopathological data from
Ramesh B, Ramanan S, Srimurugan B, Fakoya AO.   +3 more
europepmc   +5 more sources

Characterization of gangliosides by direct inlet chemical ionization mass spectrometry.

Journal of Lipid Research, 1984
Permethylated derivatives of N-acetylneuraminic acid-containing GM3, N-glycolylneuraminic acid-containing GM3, GD1a, and GD1b, were analyzed by direct inlet ammonia chemical ionization (CI) mass spectrometry.
T Argia, R K Yu, T Miyatake
doaj   +1 more source

Sialylated carbohydrate chains of recombinant human glycoproteins expressed in Chinese hamster ovary cells contain traces of N-glycolylneuraminic acid [PDF]

, 1990
HPLC analysis of sialic acid released from recombinant variants of human tissue plasminogen activator, human chimeric plasminogen activator, human erythropoietin, and human follitropin, expressed in Chinese hamster ovary cells, demonstrates for each ...
Cornelis H. Hokke, Vliegenthart, Johannis F.G., Vliegenthart, J.F.G., Oostrum, J. van, Kamerling, J.P., Aldert A. Bergwerff, van Dedem, Gijs W.K., Jan van Oostrum, Bergwerff, A.A., Hokke, C.H., Gijs W.K. van Dedem, Dedem, G.W.K. van, Johannis F.G. Vliegenthart, Kamerling, Johannis P., van Oostrum, Jan, Hokke, Cornelis H., Bergwerff, Aldert A., Johannis P. Kamerling   +17 more
core   +2 more sources

Selective Oxidation of N-Glycolylneuraminic Acid Using an Engineered Galactose Oxidase Variant [PDF]

, 2019
N-Glycolylneuraminic acid (Neu5Gc) is a common cell surface ligand in animals which is not biosynthesized in humans but can be acquired in human tissue from dietary sources such as red meat. It is important to understand the relevance of this potentially
Van Munster J. M., Parmeggiani F., Reyes Martinez, Juana E., Turner, Nicholas J; id_orcid, Kress N., Bulmer, Gregory, Huang K., Birmingham, William R., Both P., Turner N. J., Flitsch, Sabine L., Parmeggiani, Fabio, Huang, Kun, Birmingham W. R., Voglmeir, Josef, Bulmer G. S., Mattey A. P., Voglmeir J., Martinez J. E. R., Flitsch S. L., Both, Peter, Van Munster, Jolanda M., Kress, Nico, Mattey, Ashley   +23 more
core   +1 more source