Results 51 to 60 of about 2,679 (152)

Expression of Human Thrombomodulin Prevents Early Thrombocytopenia and Thrombotic Microangiopathy in Pig‐to‐Nonhuman Primate Orthotopic Liver Xenotransplantation

Xenotransplantation, Volume 33, Issue 2, March/April 2026.
ABSTRACT Background Severe thrombocytopenia and coagulation dysregulation remain major barriers to survival in pig‐to‐primate liver xenotransplantation models. Methods Porcine livers with five genetic modifications (GTKO, CMAHKO, β4GalNT2KO, hCD55, and hTBM) were orthotopically transplanted into four Tibetan macaques under two conventional ...
Zhongqiang Zhang, Ting Li, Qiang Li, Bin Xie, Xinger Zhao, Jianbin Wang, Yaxun Huang, Jing Luo, Shali Wen, Yinchun Zhou, Yong Deng, Yanfang Lu, Yanyan Jiang, Jiequn Li, David K. C. Cooper, Dengke Pan, Zhongzhou Si, Haizhi Qi   +17 more
wiley   +1 more source

Treatment with Plasma Activated (Salt) Water Sterilizes Macromolecular Coatings While Maintaining Their Integrity and Functionality

Advanced Materials Interfaces, Volume 13, Issue 3, 3 February 2026.
PDMS samples were covalently coated with mucin glycoproteins and then treated with either plasma activated water (PAW) or saline (PAS) as a means of disinfection. The samples could be successfully sterilized without compromising the structural integrity or functionality of those coatings.
Bernardo Miller Naranjo, Markus Ahrens, Ádám Nemes, Petra Mela, Oliver Lieleg   +4 more
wiley   +1 more source

Efficacy and Safety of CT‐P43, a Candidate Ustekinumab Biosimilar, in Moderate‐to‐Severe Plaque Psoriasis: 52‐Week Results From a Randomised, Active‐Controlled, Double‐Blind, Phase III Study

Dermatologic Therapy, Volume 2026, Issue 1, 2026.
Equivalent efficacy—mean per cent improvement from baseline in Psoriasis Area and Severity Index (PASI) score at Week (W) 12 (primary endpoint)—was demonstrated between CT‐P43, a candidate ustekinumab biosimilar, and reference ustekinumab. This study further evaluated the efficacy, pharmacokinetics, safety and immunogenicity of CT‐P43 vs.
Kim A. Papp, Janusz Jaworski, Bartlomiej Kwiek, Jakub Trefler, Anna Dudek, Jacek C. Szepietowski, Nataliya Reznichenko, Joanna Narbutt, Wojciech Baran, Joanna Kolinek, Stefan Daniluk, Katarzyna Bartnicka-Maslowska, Adam Reich, Yuriy Andrashko, Sunghyun Kim, Yunju Bae, Dabee Jeon, Jinsun Jung, Hyunseung Lee, Woori Ko, YeJin Kim, Diamant Thaçi, Clio Dessinioti   +22 more
wiley   +1 more source

Genetic and Phylogenetic Characterization of Influenza D Viruses From South Korean Cattle, 2022–2023

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Influenza D virus (IDV) is an emerging orthomyxovirus with cattle as its principal reservoir, and D/Yama2019‐lineage viruses have become dominant in East Asia. Although IDV has been detected in Korean cattle, the genomic identity, phylogenetic placement, and regional evolutionary relationships of circulating Korean strains have not been defined.
Byunghyun An, Kyungmoon Lee, Hai Quynh Do, Junho Yoon, Songyi Kim, Eulhae Ga, Jong-Woo Lim, Minjoo Yeom, Dongjun An, Daesub Song, Lu Lu   +10 more
wiley   +1 more source

The Role of Non-Human Sialic Acid Neu5Gc-Containing Glycoconjugates in Human Tumors: A Review of Clinical and Experimental Evidence

Biomolecules
N-Glycolylneuraminic acid (Neu5Gc) is a sialic acid variant commonly found in most mammals but not synthesized by humans due to an inactivating mutation in the CMP-Neu5Ac hydroxylase (CMAH) gene. Despite this, Neu5Gc-containing molecules are consistently
Rancés Blanco, Juan P. Muñoz
doaj   +1 more source

Molecular recognition of gangliosides and their potential for cancer immunotherapies

Frontiers in Immunology, 2014
Gangliosides are sialic acid-containing glycosphingolipids expressed on all vertebrate cells. They are primarily positioned in the plasma membrane, with the ceramide part anchored in the membrane and the glycan part exposed on the surface of the cell ...
Ute eKrengel, Paula A Bousquet
doaj   +1 more source

Elevation of serum N-glycolylneuraminic acid glycoconjugates in colorectal cancer

Biochemical and Biophysical Research Communications
Colorectal cancer (CRC) is the third most common cancer globally and a major contributor to cancer-related mortality. Implementation of screening programs in average-risk populations have reduced CRC-related mortality, despite the suboptimal sensitivity of currently used techniques.
Xavier De Bisscop, Lucy K. Shewell, Christopher J. Day, Michael P. Jennings   +3 more
openaire   +2 more sources

The use of transgenic animals for xenotransplantation: An update

Animal Models and Experimental Medicine, Volume 8, Issue 11, Page 2041-2052, November 2025.
One way to produce genetically modified pigs is to use somatic cell nuclear transfer (SCNT). This procedure involves removing the metaphase plate from a mature oocyte using micromanipulation and then transferring the modified nucleus from the donor somatic cell to the oocyte.
Julia Motławska, Ana Amaral, Marta Cerveira‐Pinto, Paweł Kordowitzki   +3 more
wiley   +1 more source

Gangliosides of human, bovine, and rabbit plasma

Journal of Lipid Research, 1972
Gangliosides were isolated from human, bovine, and rabbit plasma and were quantified by gas–liquid chromatography. Purification was achieved by sequential use of partitioning in solvents, DEAE-Sephadex chromatography, base treatment, and silicic acid ...
Robert K. Yu, Robert W. Ledeen
doaj   +1 more source

Delineation of the epitope recognized by an antibody specific for N-glycolylneuraminic acid--containing gangliosides [PDF]

Glycobiology, 1998
P3 is a mouse monoclonal antibody (mAb) that binds to several NeuGc-containing gangliosides. It also reacts with antigens expressed in human breast tumors (Vázquez et al. (1995) Hybridoma , 14, 551-556). In this work, the binding specificity of P3 has been characterized in more detail using a panel of glycolipids that included several disialylated ...
E, Moreno, B, Lanne, A M, Vázquez, I, Kawashima, T, Tai, L E, Fernández, K A, Karlsson, J, Angström, R, Pérez   +8 more
openaire   +2 more sources