Results 1 to 10 of about 2,006 (151)
Gene Expression and Pathway Analysis of Effects of the CMAH Deactivation on Mouse Lung, Kidney and Heart [PDF]
PLoS ONE, 2014 N-glycolylneuraminic acid (Neu5Gc) is generated by hydroxylation of CMP-Neu5Ac to CMP-Neu5Gc, catalyzed by CMP-Neu5Ac hydroxylase (CMAH). However, humans lack this common mammalian cell surface molecule, Neu5Gc, due to inactivation of the CMAH gene ...
Deug-Nam Kwon, Jin-Hoi Kim
exaly +3 more sources
Molecular Characterization of the Cytidine Monophosphate-N-Acetylneuraminic Acid Hydroxylase (CMAH) Gene Associated with the Feline AB Blood Group System [PDF]
PLoS ONE, 2016 Cat's AB blood group system (blood types A, B, and AB) is of major importance in feline transfusion medicine. Type A and type B antigens are Neu5Gc and Neu5Ac, respectively, and the enzyme CMAH participating in the synthesis of Neu5Gc from Neu5Ac is ...
Toshinori Omi +2 more
exaly +3 more sources
Pathogens, 2023 Porcine meat is the most consumed red meat worldwide. Pigs are also vital tools in biological and medical research. However, xenoreactivity between porcine’s N-glycolylneuraminic acid (Neu5Gc) and human anti-Neu5Gc antibodies poses a significant ...
Doreen Becker, Oluwamayowa Ogun
exaly +3 more sources
BMC Genomics, 2021 Background Cytidine monophospho-n-acetylneuraminic acid hydroxylase (CMAH) gene associated with blood groups in cats encodes CMAH enzyme that converts Neu5Ac to Neu5Gc.
Mert Döşkaya +2 more
exaly +2 more sources
Molecular characterization of blood type A, B, and C (AB) in domestic cats and a CMAH genotyping scheme [PDF]
PLoS ONE, 2018 In domestic cats, the AB blood group system consists of the three types A, B, and C (usually called AB), which vary in frequency among breeds and geographic regions.
Karthik Raj +2 more
exaly +2 more sources
Canine Genetics and Epidemiology, 2019 Background N-glycolylneuraminic acid (Neu5Gc) is synthesized from its precursor N-acetylneuraminic acid (Neu5Ac) by cytidine-5′-monophospho-N acetylneuraminic acid hydroxylase (CMAH), which is encoded by the CMAH gene.
Toshinori Omi, Kazuhiko Ochiai
exaly +3 more sources
Does Amyotrophic Lateral Sclerosis (ALS) Have Metabolic Causes from Human Evolution? [PDF]
CellsAs so many drugs have failed in ALS a new approach is needed. The author proposes that recent human genetic variants may play major roles in the disease, changing metabolism.
Michael Spedding
doaj +2 more sources
Double Electroporation Combined with Zona Pellucida Removal Improves Biallelic Genome Editing Efficiency in Porcine Embryos [PDF]
AnimalsThe CRISPR/Cas9 system has been widely used for gene editing in various species; however, mosaicism remains a significant challenge. This study aimed to improve gene editing efficiency and reduce mosaicism in porcine embryos by exploring double ...
Nanaka Torigoe +9 more
doaj +2 more sources
Inactivation of the CMAH gene and deficiency of Neu5Gc play a role in human brain evolution [PDF]
Inflammation and RegenerationDuring human evolution, some genes were lost or silenced from the genome of hominins. These missing genes might be the key to the evolution of humans’ unique cognitive skills. An inactivation mutation in CMP-N-acetylneuraminic acid hydroxylase (CMAH) was
Yuxin Liu, Jinhong Li, Qicai Liu
doaj +2 more sources
Molecular Therapy - Nucleic Acids, 2014 Although noncancerous immortalized cell lines have been developed by introducing genes into human and murine somatic cells, such cell lines have not been available in large domesticated animals like pigs.
Byeong Chun Lee, Goo Jang, Jin-Soo Kim
exaly +3 more sources