Results 1 to 10 of about 23,059 (229)
Advances in Innate Immunity to Overcome Immune Rejection during Xenotransplantation
Cells, 2022 Transplantation is an effective approach for treating end-stage organ failure. There has been a long-standing interest in xenotransplantation as a means of increasing the number of available organs.
Tian-Yu Lu +6 more
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Unraveling the impact of hyperleptinemia on female reproduction: insights from transgenic pig model
Biological ResearchBackground Infertility is a growing global health concern affecting millions of couples worldwide. Among several factors, an extreme body weight adversely affects reproductive functions. Leptin is a well-known adipokine that serves as an endocrine signal
Muhammad Ameen Jamal +17 more
doaj +1 more source
Evidence for the important role of inflammation in xenotransplantation
Journal of Inflammation, 2019 There is increasing evidence of a sustained state of systemic inflammation after pig-to-nonhuman primate (NHP) xenotransplantation (that has been termed systemic inflammation in xenograft recipients [SIXR]).
Juan Li +5 more
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Ethical issues of xenotransplantation in the aspect of religious views
Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье, 2022 Transplantation allows us to confidently save the lives of previously doomed patients. Unfortunately, this colossal achievement of human progress has a problematic side – the shortage of donor organs. The use of animal organs could solve it.
R. A. Sharifova +4 more
doaj +1 more source
Lung xenotransplantation [PDF]
Current Opinion in Organ Transplantation, 2017 This review describes the most recent progress in xeno lung transplantation (XLTx) to date. It describes the potential mechanisms of early xeno lung graft loss, as well as the latest therapeutic strategies to overcome them.Using ex-vivo perfusion models of porcine lungs with human blood, the use of genetically modified pig lungs along with novel ...
Hisashi, Sahara +3 more
openaire +2 more sources
Epigenetic Drift and the Generational Limit of Serial Somatic Cell Nuclear Transfer in Pigs
AnimalsSomatic cell nuclear transfer (SCNT) in pigs has been a widely used technique for producing gene-edited pigs for biomedical research, yet its wide-spread application through serial cloning remains markedly limited.
Na Cheng +6 more
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Expert consensus on clinical trials of human xenotransplantation in China
Health Care Science, 2022 The history of xenotransplantation started in the 19th century. After a few decades of investigation, significant breakthroughs and preclinical milestones have been achieved worldwide.
Jiefu Huang +1 more
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Generation of RAG2 Knockout Immune-Deficient Miniature Pigs
AnimalsRecombination-activating genes (RAGs) play a crucial role in the V(D)J recombination process and the development of immune cells. The development of the immune system and its mechanisms in pigs exhibit greater similarity to those of humans compared to ...
Jing Wang +8 more
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AnimalsTelomerase reverse transcriptase subunit (TERT) is a key factor involved in telomere maintenance and genome stability, and the decline in its expression is closely related to cellular senescence.
Yanhong Yang +9 more
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Pig-to-Primate Islet Xenotransplantation: Past, Present, and Future
Cell Transplantation, 2017 Islet allotransplantation results in increasing success in treating type 1 diabetes, but the shortage of deceased human donor pancreata limits progress. Islet xenotransplantation, using pigs as a source of islets, is a promising approach to overcome this
Zhengzhao Liu +8 more
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