Results 1 to 10 of about 21,110 (223)

Xenotransplantation [PDF]

British Medical Bulletin, 1999
Xenotransplantation is a potentially promising but exceedingly complex issue. It is critical that this subject be discussed within and outside the transplant community.
Linda H. McBride, Kathleen M. Kinter, Roxanne M. Taylor, Rene H. Hogarth   +3 more
core   +11 more sources

Recent progress in pig-to-human kidney xenotransplantation [PDF]

Frontiers in Immunology
Even though the patient kept up his dialysis regimen as he had before xenotransplantation, this is a significant development for xenotransplantation. This benchmark for xenotransplantation has the following significant findings. Firstly, from the patient’
Pei Tao, Pei Tao, Kaiyu Zhou
doaj   +2 more sources

Xenotransplantation [PDF]

Journal of Internal Medicine, 1996
Kemp E (Department of Nephrology, Odense University Hospital, Odense, Denmark). Xenotransplantation (Review). J Intern Med 1996; 239: 287–97.Xenotransplantation means transplantation of organs and tissues from animals to human beings. Today, with use of new and more conventional immunosuppressive substances, it is possible to achieve good long‐term ...
Cozzi E., White D. J. G.
openaire   +4 more sources

Efficient Generation of P53 Biallelic Mutations in Diannan Miniature Pigs Using RNA-Guided Base Editing

Life, 2021
The base editing 3 (BE3) system, a single-base gene editing technology developed using CRISPR/Cas9n, has a broad range of applications for human disease model construction and gene therapy, as it is highly efficient, accurate, and non-destructive.
Honghui Li, Wenmin Cheng, Bowei Chen, Shaoxia Pu, Ninglin Fan, Xiaolin Zhang, Deling Jiao, Dejia Shi, Jianxiong Guo, Zhuo Li, Yubo Qing, Baoyu Jia, Hong-Ye Zhao, Hong-Jiang Wei   +13 more
doaj   +1 more source

Construction of PIK3C3 Transgenic Pig and Its Pathogenesis of Liver Damage

Life, 2022
As a member of the PIKs family, PIK3C3 participates in autophagy and plays a central role in liver function. Several studies demonstrated that the complete suppression of PIK3C3 in mammals can cause hepatomegaly and hepatosteatosis. However, the function
Jing Wang, Sami Ullah Khan, Pan Cao, Xi Chen, Fengchong Wang, Di Zou, Honghui Li, Heng Zhao, Kaixiang Xu, Deling Jiao, Chang Yang, Feiyan Zhu, Yaxuan Zhang, Yanhua Su, Wenmin Cheng, Baoyu Jia, Yubo Qing, Muhammad Ameen Jamal, Hong-Ye Zhao, Hong-Jiang Wei   +19 more
doaj   +1 more source

Differences in platelet aggregometers to study platelet function and coagulation dysregulation in xenotransplantation [PDF]

, 2021
Xenotransplantation (ie, cross-species transplantation) using genetically engineered pig organs could be a limitless source to solve the shortage of organs and tissues worldwide.
Burcin Ekser, Yilmaz, Sezai, Li, Ping, Sezai Yilmaz, Isidan, Abdulkadir, Zhang, Wenjun, Angela M. Chen, Saglam, Kutay, Abdulkadir Isidan, Ekser, Burcin, Ping Li, Kutay Saglam, Wenjun Zhang, Chen, Angela M.   +13 more
core   +1 more source

Lebanese medical students’ knowledge on and attitude toward xenotransplantation and its ethical issues: A cross‐sectional study [PDF]

, 2022
Introduction: Xenotransplantation is the transplantation of animal parts into humans. This study's aim is to assess the Lebanese medical students’ attitude toward xenotransplantation and their knowledge of its related ethical issues.
Mokled, Elie, Thea Kaady, Safi, Steven, Mansour, Perla C., Salameh, Pascale R., Perla C. Mansour, El Kareh, Antonio, Kaady, Théa, Steven Safi, Pascale Salameh, Elie Mokled, Antonio El Kareh   +11 more
core   +1 more source

Development of a Lung Vacancy Mouse Model through CRISPR/Cas9-Mediated Deletion of Thyroid Transcription Factor 1 Exon 2

Cells, 2022
A developmental niche vacancy in host embryos is necessary for stem cell complementation-based organ regeneration (SCOG). Thyroid transcription factor 1 (TTF-1) is a tissue-specific transcription factor that regulates the embryonic development and ...
Lihua Zhao, Meishuang Li, Zhibao Yin, Limin Lv, Meng Zhou, Yixi Wang, Manling Zhang, Tianxu Guo, Xiyun Guo, Han Liu, Linxin Cheng, Xiubin Liang, Shuguang Duo, Rongfeng Li   +13 more
doaj   +1 more source

Small Ruminant Farming in Tribal Areas of Dera Ghazi Khan, Punjab, Pakistan

Veterinary Sciences, 2022
Provincially Administered Tribal Areas (PATA) of Punjab-Pakistan are comprised of hilly mountains with small ruminants as a sole source of income. In this study, farming practices, productivity, health and the economic value of sheep were evaluated in ...
Muhammad Ameen Jamal, Samiullah Khan, Yanhua Su, Chang Yang, Heng Zhao, Kaixiang Xu, Deling Jiao, Wenmin Cheng, Abdul Rauf, Mahboob Ali, Sohail Ahmad, Yubo Qing, Hong-Jiang Wei   +12 more
doaj   +1 more source

TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk

Hepatology, EarlyView., 2022
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam, Jianqing Yu, Hao Huang, Xiaofan Ding, Alissa M. Wong, Howard H. Leung, Anthony W. Chan, Kelvin K. Ng, Mingjing Xu, Xin Wang, Nathalie Wong   +10 more
wiley   +1 more source