Results 41 to 50 of about 23,059 (229)

Tolerance in xenotransplantation [PDF]

Current Opinion in Organ Transplantation, 2017
This review describes recent progress in tolerance-inducing strategies across xenogeneic immunological barriers as well as the potential benefit of a tolerance strategy for islets and kidney xenotransplantation.Using advanced gene editing technologies, xenotransplantation from multitransgenic alpha-1,3-galactosyltransferase knockout pigs has ...
Kazuhiko, Yamada, Megan, Sykes, David H, Sachs   +2 more
openaire   +2 more sources

Organs from animals for man [PDF]

, 1998
In the following review some of the problems of xenotransplantation shall be discussed, based on the few experimental data available so far and on reports in the literature describing investigations which may be of importance for xenotransplantation. The
Diefenbeck, M., Hammer, C., Wagner, F., Linke, R.   +3 more
core   +1 more source

The Swiss Technology Assessment Project on Xenotransplantation

, 2022
S.155-165The Swiss Technology Assessment (TA) project on xenotransplantation is intended to study the opportunities and risks of this technique, recognizing the input of those involved in and those affected by it.
Rüegsegger, A., Husing, B., Bellucci, S., Bondolfi, A.   +3 more
core   +1 more source

Evidence for GTKO/β4GalNT2KO Pigs as the Preferred Organ-source for Old World Nonhuman Primates as a Preclinical Model of Xenotransplantation

Transplantation Direct, 2020
Background. Triple-knockout (TKO) pigs (in which expression of the 3 known pig carbohydrate xenoantigens has been deleted) are likely to be an optimal source of organs for transplantation into human recipients, many of whom do not have natural antibodies
Yehua Cui, MD, Takayuki Yamamoto, MD, PhD, Syed Sikandar Raza, BA, Mahmoud Morsi, MD, Huy Quoc Nguyen, BS, David Ayares, PhD, David K.C. Cooper, MD, PhD, Hidetaka Hara, MD, PhD   +7 more
doaj   +1 more source

The history of cardiac xenotransplantation: early attempts, major advances, and current progress

Frontiers in Transplantation, 2023
In light of ongoing shortage of donor organs for transplantation, alternative sources for donor organ sources have been examined to address this supply-demand mismatch.
Nicholas R. Hess, David J. Kaczorowski, David J. Kaczorowski   +2 more
doaj   +1 more source

Sensitive detection systems for infectious agents in xenotransplantation*

Xenotransplantation, EarlyView., 2020
Abstract Xenotransplantation of pig cells, tissues, or organs may be associated with transmission of porcine microorganisms, first of all of viruses, to the transplant recipient, potentially inducing a disease (zoonosis). I would like to define detection systems as the complex of sample generation, sample preparation, sample origin, time of sampling ...
Joachim Denner
wiley   +1 more source

Quantification of Islet Cell Cluster Size Heterogeneity in Early Postnatal Porcine Pancreas. [PDF]

Xenotransplantation
ABSTRACT Donor scarcity limits islet transplantation for type 1 diabetes. Early postnatal piglets are a potential xenogeneic source of endocrine tissue, yet their immature islet cell clusters (ICCs) remain insufficiently characterised with respect to size and maturation.
Cruz DM, Frick J, Adamina M, Bühler L, Gonelle-Gispert C.   +4 more
europepmc   +2 more sources

Clinical xenotransplantation [PDF]

Xenotransplantation, 1994
Abstract: Two baboon liver xenografts transplanted to patients with B virus hepatitis supported life for 70 and 26 days but did not function optimally despite minimum or no histopathologic findings of overt humoral or cellular rejection in serial biopsies.
Starzl, TE, Murase, N, Tzakis, A, Fung, JJ, Todo, S, Demetris, AJ, Manez, R, Marino, IR, Valdivia, L   +8 more
openaire   +2 more sources

Xenotransplantation-associated infectious risk: a WHO consultation

, 2020
Xenotransplantation carries the potential risk of the transmission of infection with the cells or tissues of the graft. The degree of risk is unknown in the absence of clinical trials.
Scobie, Linda, Fishman, Jay, Takeuchi, Yasuhiro   +2 more
core   +1 more source

Experimental multivisceral xenotransplantation

, 2008
Background: Organ shortage impairs the proposition of multivisceral transplantation to treat multiple organ failure. Interspecies (xeno) transplantation is a valid solution for organ shortage; however, suitable models of this advance are lacking.
COSTA, Anderson da Costa Lino, POMPEU, Eduardo, GALVAO, Flavio Henrique, MACHADO, Marcel Cesar, MELLO, Evandro Sobroza de, MORY, Eduardo, SANTOS, Rafael Miyashiro dos, SANTOS, Vinicius Rocha, BACCHELLA, Telesforo   +8 more
core   +1 more source