Results 51 to 60 of about 15,793 (179)
MLH1 p.His112Arg Variant Is Associated With Increased Cancer Susceptibility
International Journal of Cancer, EarlyView.ABSTRACT Lynch syndrome, a prevalent hereditary cancer predisposition, is frequently caused by pathogenic variants in the MutL homolog 1 (MLH1) mismatch repair gene. However, a significant proportion of MLH1 missense variants remain classified as variants of uncertain significance (VUS), creating clinical ambiguity.
Amal Elfatih +10 more
wiley +1 more source
Ethical issues of xenotransplantation in the aspect of religious views
Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье, 2022 Transplantation allows us to confidently save the lives of previously doomed patients. Unfortunately, this colossal achievement of human progress has a problematic side – the shortage of donor organs. The use of animal organs could solve it.
R. A. Sharifova +4 more
doaj +1 more source
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Background Immunotherapy response rates in head and neck squamous cell carcinoma (HNSCC) are limited by multiple factors. Tumor cell‐derived follistatin (FST) has been linked to immunotherapy resistance, but the underlying mechanisms remain poorly understood. This study aimed to investigate the prognostic value of FST and its associations with
Pan Song +6 more
wiley +1 more source
A Spotlight on Yolk‐sac Tumors: Molecular Pathology, Current Diagnostics, and Novel Therapeutics
Andrology, EarlyView.ABSTRACT Background Yolk‐sac tumors are an aggressive subtype of testicular cancer that significantly contribute to disease progression and therapy resistance, especially in adults. While testicular cancer generally has high cure rates with cisplatin‐based treatment, adult yolk‐sac tumors often appear as components of mixed tumors with poor response to
Evangelos Prokakis +3 more
wiley +1 more source
Epigenetic Drift and the Generational Limit of Serial Somatic Cell Nuclear Transfer in Pigs
AnimalsSomatic cell nuclear transfer (SCNT) in pigs has been a widely used technique for producing gene-edited pigs for biomedical research, yet its wide-spread application through serial cloning remains markedly limited.
Na Cheng +6 more
doaj +1 more source
Expert consensus on clinical trials of human xenotransplantation in China
Health Care Science, 2022 The history of xenotransplantation started in the 19th century. After a few decades of investigation, significant breakthroughs and preclinical milestones have been achieved worldwide.
Jiefu Huang +1 more
doaj +1 more source
An Enquiry on the Ethics of One Medicine
Bioethics, EarlyView.ABSTRACT One Medicine is not One Health. Although both concepts connect animal and human health, One Health has arguably become a frame for public health. This paper argues that One Medicine uniquely centres on animal and human patients and speaks to the equal interdependence of their health, though it has also (historically) been adopted as a response
Benjamin Capps +2 more
wiley +1 more source
Generation of RAG2 Knockout Immune-Deficient Miniature Pigs
AnimalsRecombination-activating genes (RAGs) play a crucial role in the V(D)J recombination process and the development of immune cells. The development of the immune system and its mechanisms in pigs exhibit greater similarity to those of humans compared to ...
Jing Wang +8 more
doaj +1 more source
Bioethics, EarlyView.ABSTRACT According to Faden and Beauchamp's influential model, an action is autonomous when it is done intentionally with understanding and in the absence of controlling influences. Recent debates concerning nudges have shown, however, that this last condition gives limited ethical guidance for assessing the ethical permissibility of manipulative ...
Pepijn Al
wiley +1 more source
Pig-to-Primate Islet Xenotransplantation: Past, Present, and Future
Cell Transplantation, 2017 Islet allotransplantation results in increasing success in treating type 1 diabetes, but the shortage of deceased human donor pancreata limits progress. Islet xenotransplantation, using pigs as a source of islets, is a promising approach to overcome this
Zhengzhao Liu +8 more
doaj +1 more source