Results 71 to 80 of about 15,793 (179)

Infection in xenotransplantation

BMJ, 2000
Advances in transplantation immunology have enhanced the possibility of xenotransplantation as a therapeutic option for end-stage organ failure. The potential spread of animal-derived pathogens to the recipient and to the general population, termed "xenosis," is a potential complication of interspecies transplantation.
openaire   +4 more sources

Macrophages in xenotransplantation [PDF]

Korean Journal of Transplantation, 2019
Xenotransplantation refers to organ transplantation across species. Immune rejection of xenografts is stronger and faster than that of allografts because of significant molecular differences between species. Recent studies have revealed the involvement of macrophages in xenograft and allograft rejections.
openaire   +3 more sources

Lineage switch in childhood leukemia

HemaSphere, Volume 10, Issue 11, November 2026.
Abstract Lineage switch (LS) is a rare but aggressive immunophenotypic transformation of acute leukemia associated with limited therapeutic options and poor clinical outcome. Although LS has been increasingly recognized in the era of CD19‐directed immunotherapies, its biological basis remains incompletely understood.
Katharina Daugs, Anna Prazmo, Anindita Roy, Arndt Borkhardt   +3 more
wiley   +1 more source

Dysfunction of Complementarity Determining Region 1 Encoded by T Cell Receptor Beta Variable Gene Is Potentially Associated with African Swine Fever Virus Infection in Pigs

Microorganisms
The beta T-cell receptor (TRB) expressed by beta T cells is essential for foreign antigen recognition. The TRB locus contains a TRBV family that encodes three complementarity determining regions (CDRs).
Jiayu Li, Huiyan Xing, Kai Liu, Ninglin Fan, Kaixiang Xu, Heng Zhao, Deling Jiao, Taiyun Wei, Wenjie Cheng, Jianxiong Guo, Xiong Zhang, Feiyan Zhu, Zhigao Bu, Dongming Zhao, Wen Wang, Hong-Jiang Wei   +15 more
doaj   +1 more source

Integrated Microbial Profiling Identifies Bacterial and Fungal Communities in Pseudomyxoma Peritonei Mucin

Microbial Biotechnology, Volume 19, Issue 11, November 2026.
Integrated profiling of pseudomyxoma peritonei mucin revealed bacterial and fungal communities spatially supported by rRNA detection. Bacterial communities also displayed histological grade‐associated differences in predicted metabolic pathways, supporting PMP mucin as a complex multi‐kingdom microbial environment. ABSTRACT Pseudomyxoma peritonei (PMP)
Rafaela Pezzopane, Marina Barbudo‐Lunar, Florina I. Bura, Melissa Granados‐Rodríguez, Ana Martínez‐López, Lidia Rodríguez‐Ortiz, Blanca Rufián‐Andújar, Javier López‐Jiménez, Verónica Luna‐Guerrero, José Alhama, Carmen Michán, Mari C. Vázquez‐Borrego, Álvaro Arjona‐Sánchez, Antonio Romero‐Ruiz   +13 more
wiley   +1 more source

Comparing the ethics of islet cell and solid organ xenotransplantation

JME Practical Bioethics
The demand for transplantable solid organs and islet cells far exceeds the supply of available human donors. In response to this persistent shortage, researchers are increasingly exploring the genetic engineering of pigs as a potentially scalable source ...
Daniel J Hurst, Anthony Merlocco, Christopher Alan Bobier   +2 more
doaj   +1 more source

Why Engage Communities in Biomedical Research?

Bioethics, Volume 40, Issue 9, Page 962-975, November 2026.
ABSTRACT While community engagement in biomedical research is widely lauded, and many reasons to engage communities have been adduced, it is unclear whether all these reasons are equally important, and, if not, which are most important. Here, I argue that, outside of rare circumstances, community engagement should not be understood as seeking ...
Robert Steel
wiley   +1 more source

3D-printed dictamni-calcium silicate scaffolds modulate the osteoimmune microenvironment and enhance macrophage-derived exosomal miR-21 signaling in vascularized bone regeneration

Journal of Nanobiotechnology
Reconstruction of critical-sized bone defects remains a formidable clinical challenge due to a persistent, localized, pro-inflammatory microenvironment that disrupts the coordinated process of osteogenic-angiogenic coupling.
Chia-Che Ho, Tuan-Ti Hsu, Yen-Hong Lin, Ting-You Kuo, Cheng-Yu Chen, Shang-Hsiu Hu, Jen-Ting Huang, Tsung-Li Lin, Der-Yang Cho, Ming-You Shie   +9 more
doaj   +1 more source

Increasing Follicular and Stromal Cell Proliferation in Cryopreserved Human Ovarian Tissue after Long-Term Precooling Prior to Freezing: In Vitro versus Chorioallantoic Membrane (CAM) Xenotransplantation

Cell Transplantation, 2013
A positive effect on the future development of cells, which have been cooled to low suprazero temperatures and then thawed, has been observed before and is not new.
Vladimir Isachenko, Evgenia Isachenko, Peter Mallmann, Gohar Rahimi   +3 more
doaj   +1 more source

Histone deacetylase inhibitors as venetoclax‐sensitising partners in acute myeloid leukaemia: Mechanisms, pharmacology and translational perspectives

British Journal of Pharmacology, Volume 183, Issue 21, Page 6261-6290, November 2026.
Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley   +1 more source