Results 81 to 90 of about 15,793 (179)

Mitochondrial Morphology Dynamics Remodel Metabolism and Affect TKI Sensitivity in EGFR‐Mutated Lung Cancer

Cancer Science, Volume 117, Issue 11, Page 3022-3038, November 2026.
TKI treatment promotes mitochondrial fission and metabolic reprogramming toward oxidative phosphorylation in residual EGFR‐mutant lung cancer cells. Targeting this metabolic vulnerability restores TKI sensitivity and provides a promising strategy to overcome acquired resistance.
Yu Zhao, Yuqiang Liu, Mingxuan Xie, Zhiming Ye, Hong Huang, Maojin Yao, Feng Zhou, Jianzhu Zhao, Jun Tang   +8 more
wiley   +1 more source

Establishment of Allogeneic Kidney Transplantation Technical System in Banna Miniature Pig Inbred Strain

Shiyan dongwu yu bijiao yixue
ObjectiveTo establish a technical system for allogeneic kidney transplantation surgery in pigs using the Banna miniature pig inbred strain, and to evaluate it through routine blood tests, liver and kidney function tests, thus providing reference data for
ZHANG Ying, PENG Ziwei, YANG Chang, WANG Jing, ZHAO Hongfang, CHEN Gen, ZHAO Hongye, WEI Hongjiang   +7 more
doaj   +1 more source

Detection of Pig Cells Harboring Porcine Endogenous Retroviruses in Non-Human Primate Bladder After Renal Xenotransplantation

Viruses, 2019
Pigs are used as potential donor animals for xenotransplantation. However, porcine endogenous retrovirus (PERV), shown to infect both human and non-human primate (NHP) cells in vitro, presents a risk of transmission to humans in xenotransplantation.
Yoonki Heo, Yeondong Cho, Keon Bong Oh, Ki Hoon Park, Hansam Cho, Hanul Choi, Minjee Kim, Ik Jin Yun, Hee Jung Lee, Young Bong Kim   +9 more
doaj   +1 more source

The case for xenotransplantation [PDF]

Clinical Transplantation, 2015
AbstractThe availability of organs and cells from deceased humans for transplantation is not meeting the demand. Xenotransplantation, specifically the transplantation of organs and cells from genetically engineered pigs, could resolve this problem. Diabetic monkeys have remained normoglycemic and insulin‐independent after pig islet transplantation for &
openaire   +2 more sources

Characterization and phylogenetic analysis of the complete mitochondrial genome of Cotylorhiza tuberculata assembled using next-generation sequencing

Mitochondrial DNA. Part B. Resources
In this study, the complete mitochondrial genome (mitogenome) of Cotylorhiza tuberculata (Scyphozoa; Rhizostomeae; Cepheidae) was assembled by the next-generation sequencing data.
Hui Jiang, Wangxiao Xia, Shaoxia Pu, Yanhua Su, Anzhu Zhu, Hongye Zhao, Hongjiang Wei, Yaowen Liu   +7 more
doaj   +1 more source

Immunobiology of xenotransplantation [PDF]

Transplant International, 2000
The transplantation of organs between disparate species is hindered by severe immune responses of the recipient against the graft. These immune responses gives rise to hyperacute and acute vascular rejection and to cellular rejection. Research during the past decade has shed light on the elements of the immune system responsible for the rejection of ...
openaire   +2 more sources

A chromosome-scale reference genome of the Banna miniature inbred pig

Scientific Data
The Banna miniature inbred pig (BN) is an intensively inbred line for biomedical research and xenotransplantation due to its low individual variation and stable genetic background.
Hong-Man Chen, Kai-Xiang Xu, Chen Yan, Heng Zhao, De-Ling Jiao, Si Si, Zheng-Xi Liu, Guo-Ying Peng, Muhammad Ameen Jamal, Min-Juan Lv, Pei Wang, Yang-Zhi Zeng, Hong-Ye Zhao, Ming-Shan Wang, Hong-Jiang Wei   +14 more
doaj   +1 more source

Mitigating Cross-Species Viral Infections in Xenotransplantation: Progress, Strategies, and Clinical Outlook

Cell Transplantation
Xenotransplantation holds great promise as a solution to address the critical shortage of organs, but it raises concerns regarding the potential transmission of porcine viruses to recipients, leading to infections and even zoonotic diseases. Data used in
Yenong Zhou, Shuyu Zhou, Qian Wang, Bing Zhang   +3 more
doaj   +1 more source

Clinical Islet Xenotransplantation: Development of Isolation Protocol, Anti-Rejection Strategies, and Clinical Outcomes

Cells
Allogeneic islet transplantation has become a standard therapy for unstable type 1 diabetes. However, considering the large number of type 1 diabetic patients, the shortage of donors is a serious issue.
Shinichi Matsumoto, Kyohei Matsumoto
doaj   +1 more source

Moral approval of xenotransplantation in Egypt: associations with religion, attitudes towards animals and demographic factors

BMC Medical Ethics
Xenotransplantation has great potential as an alternative to alleviate the shortage of organs for donation. However, given that the animal most suited for xenotransplantation is the pig, there are concerns that people in Muslim countries may be more ...
Gabriel Andrade, Eid AboHamza, Yasmeen Elsantil, AlaaEldin Ayoub, Dalia Bedewy   +4 more
doaj   +1 more source