Results 61 to 70 of about 15,793 (179)
Phagocytosis activity is retained by JMML macrophages and increased by CD47 inhibition
British Journal of Haematology, EarlyView.Summary Juvenile myelomonocytic leukaemia (JMML) is a childhood myeloid malignancy driven by RAS (rat sarcoma viral oncogene homolog) pathway mutations, characterized by myeloid cell accumulation and organ infiltration. We investigated how clonal macrophage polarization, phagocytic function and CD47 (cluster of differentiation 47) expression contribute
Jun Wang +11 more
wiley +1 more source
Health Care Science, 2023 Background Xenotransplantation is a potential way to reduce the shortage of the needed organ grafts for the end‐stage disease. Immune rejection, physiological incompatibility and bio‐safety are the most critical issues.
Xiaoqian Ma +4 more
doaj +1 more source
Journal of Diabetes Investigation, EarlyView.ABSTRACT Over the past century, the discovery of insulin transformed type 1 diabetes from a fatal disease into a manageable chronic condition, and the subsequent recognition of its autoimmune basis laid the foundation for screening and intervention before clinical onset.
Noriko Kodani
wiley +1 more source
AnimalsTelomerase reverse transcriptase subunit (TERT) is a key factor involved in telomere maintenance and genome stability, and the decline in its expression is closely related to cellular senescence.
Yanhong Yang +9 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, Volume 600, Issue 21, Page 3186-3200, November 2026.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, Volume 600, Issue 21, Page 3265-3285, November 2026.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Data in Brief, 2018 This report is related to the research article entitled “B cell phenotypes in baboons with pig artery patch grafts receiving conventional immunosuppressive therapy” (Yamamoto et al., in press).
Takayuki Yamamoto +14 more
doaj +1 more source
Induction of diabetes in cynomolgus monkey with one shot of analytical grade streptozotocin
Animal Models and Experimental Medicine, 2020 Backgrounds Streptozotocin (STZ)‐ induced diabetic monkey is a wide used preclinical animal model for the investigation of diabetes such as islet transplantation and development of diabetic drugs.
Zhengzhao Liu +6 more
doaj +1 more source
Xenotransplantation at a Crossroads: Breakthroughs, Challenges, and the Path Forward
Organ Medicine, EarlyView.
Xiaoyu Gan +3 more
wiley +1 more source
HemaSphere, Volume 10, Issue 11, November 2026.Abstract Advanced mycosis fungoides (MF) and Sézary syndrome (SS) are the most aggressive forms of cutaneous T‐cell lymphoma and remain associated with a poor prognosis and heterogeneous therapeutic approaches. Recent advances, including targeted therapies and improved transplant strategies, have substantially expanded treatment options, highlighting ...
Francesco Onida +29 more
wiley +1 more source