Results 61 to 70 of about 21,110 (223)
Expert consensus on clinical trials of human xenotransplantation in China
Health Care Science, 2022 The history of xenotransplantation started in the 19th century. After a few decades of investigation, significant breakthroughs and preclinical milestones have been achieved worldwide.
Jiefu Huang +1 more
doaj +1 more source
Double knockout pigs deficient in N-glycolylneuraminic acid and galactose α-1,3-galactose reduce the humoral barrier to xenotransplantation [PDF]
, 2013 Clinical xenotransplantation is not possible because humans possess antibodies that recognize antigens on the surface of pig cells. Galα-1,3-Gal (Gal) and N-glycolylneuraminic acid (Neu5Gc) are two known xenoantigens.
Paris, Leela L +13 more
core +1 more source
Frontiers in Immunology, 2021 BackgroundIn pig-to-baboon transplantation models, there is increasing evidence of systemic inflammation in xenograft recipients (SIXR) associated with pig xenograft failure.
Guoqiang Zhang +10 more
doaj +1 more source
A Spotlight on Yolk‐sac Tumors: Molecular Pathology, Current Diagnostics, and Novel Therapeutics
Andrology, EarlyView.ABSTRACT Background Yolk‐sac tumors are an aggressive subtype of testicular cancer that significantly contribute to disease progression and therapy resistance, especially in adults. While testicular cancer generally has high cure rates with cisplatin‐based treatment, adult yolk‐sac tumors often appear as components of mixed tumors with poor response to
Evangelos Prokakis +3 more
wiley +1 more source
Live encapsulated porcine islets from a type 1 diabetic patient 9.5 yr after xenotransplantation [PDF]
, 2007 The long-term viability and function of transplanted encapsulated neonatal porcine islets was examined in a diabetic patient. Methods and results: A 41-yr-old Caucasian male with type 1 diabetes for 18 yr was given an intraperitoneal transplant of ...
Muzina, M +4 more
core +1 more source
Generation of RAG2 Knockout Immune-Deficient Miniature Pigs
AnimalsRecombination-activating genes (RAGs) play a crucial role in the V(D)J recombination process and the development of immune cells. The development of the immune system and its mechanisms in pigs exhibit greater similarity to those of humans compared to ...
Jing Wang +8 more
doaj +1 more source
Pig-to-Primate Islet Xenotransplantation: Past, Present, and Future
Cell Transplantation, 2017 Islet allotransplantation results in increasing success in treating type 1 diabetes, but the shortage of deceased human donor pancreata limits progress. Islet xenotransplantation, using pigs as a source of islets, is a promising approach to overcome this
Zhengzhao Liu +8 more
doaj +1 more source
Health Care Science, 2023 Background Xenotransplantation is a potential way to reduce the shortage of the needed organ grafts for the end‐stage disease. Immune rejection, physiological incompatibility and bio‐safety are the most critical issues.
Xiaoqian Ma +4 more
doaj +1 more source
Why Engage Communities in Biomedical Research?
Bioethics, EarlyView.ABSTRACT While community engagement in biomedical research is widely lauded, and many reasons to engage communities have been adduced, it is unclear whether all these reasons are equally important, and, if not, which are most important. Here, I argue that, outside of rare circumstances, community engagement should not be understood as seeking ...
Robert Steel
wiley +1 more source
AnimalsTelomerase reverse transcriptase subunit (TERT) is a key factor involved in telomere maintenance and genome stability, and the decline in its expression is closely related to cellular senescence.
Yanhong Yang +9 more
doaj +1 more source