Results 101 to 110 of about 31,863 (228)

Dedicatory Essay: Honoring Ian McColl Kennedy [PDF]

, 1997
Ian Kennedy is perhaps the best known and most important figure in health law and ethics in the United Kingdom, and probably one of the most significant in Europe and North America.
Gostin, Lawrence O.
core   +1 more source

Effect of anticomplement agent K-76 COOH in hamster-to-rat and guinea pig- to-rat xenotransplantation [PDF]

, 1995
In normal rats, the xenobiotic K76 inhibited the C5 and probably the C2 and C3 steps of complement and effectively depressed classical complement pathway activity, alternative complement pathway activity, and the C3 complement component during and well ...
Adachi, Anthony J. Demetris, Cochrane, Gewurz, Hasan, Hideaki Miyazawa, Hong, Iida, Kissmeyer-Nielsen, Kitano, Kitano, Leventhal, Minoru Nomoto, Mitsuko Tanaka, Miyagawa, Miyagawa, Miyazaki, Miyazaki, Miyazawa, Murase, Nelson, Noriko Murase, Ono, Perper, Pruitt, Pruitt, Qing Ye, Rafael Manez, Satoru Todo, Soares, Starzl, Starzl, Starzl, Starzl, Tanaka, Thomas E. Starzl, Valdivia, Van den Bogaerde, Wasei Miyazaki, Xia, Yamamoto, Yoichi Toyama   +41 more
core   +2 more sources

Generation of Cloned Sheep Lacking Galactose‐α1,3‐Galactose and N‐Glycolylneuraminic Acid Antigens

Xenotransplantation, Volume 33, Issue 3, May/June 2026.
ABSTRACT Livestock have long been regarded as a potential source of donor organs to alleviate the global organ shortage for transplantation. Sheep have a similar anatomy to humans, providing the standard model for demonstrating biocompatibility and performance of biological heart valves to obtain regulatory approval for their use in transplantation ...
Sarah J. Appleby, Lisanne M. Fermin, Zachariah L. McLean, Stephanie Delaney, Stefan Wagner, Cecilia Di Genova, Jingwei Wei, Fanli Meng, David N. Wells, Björn Oback   +9 more
wiley   +1 more source

Production of α1,3-galactosyltransferase-deficient pigs [PDF]

, 2003
The enzyme α1,3-galactosyltransferase (α1,3GT or GGTA1) synthesizes α1,3galactose (α1,3Gal) epitopes (Galα1,3Galβ1,4GlcNAc-R), which are the major xenoantigens causing hyperacute rejection in pig-to-human xenotransplantation.
Ayares, DL, Ball, S, Bertera, S, Boone, J, Bottino, R, Chen, SH, Dai, Y, Demetris, AJ, Garst, AS, Jobst, PM, Koike, C, Lamborn, AE, Monahan, JA, Moore, M, Phelps, CJ, Polejaeva, IA, Rudert, WA, Sharma, SB, Specht, SM, Starzl, TE, Trucco, M, Vaught, TD, Wells, KD   +22 more
core   +1 more source

Is There an Ethical Dilemma in Xenotransplantation?

Xenotransplantation, Volume 33, Issue 3, May/June 2026.
ABSTRACT As clinical trials in xenotransplantation commence, the question of whether participants may withdraw from research is being intensely debated. Some authors argue that xenotransplant recipients should be subject to lifelong monitoring because of the potential risk of zoonotic or xenozoonotic infections affecting third parties.
Joachim Denner
wiley   +1 more source

Mitigating Cross-Species Viral Infections in Xenotransplantation: Progress, Strategies, and Clinical Outlook

Cell Transplantation
Xenotransplantation holds great promise as a solution to address the critical shortage of organs, but it raises concerns regarding the potential transmission of porcine viruses to recipients, leading to infections and even zoonotic diseases. Data used in
Yenong Zhou, Shuyu Zhou, Qian Wang, Bing Zhang   +3 more
doaj   +1 more source

Pancreas and islet cell transplantation [PDF]

, 2002
Currently, for the patient with type 1 diabetes, a definitive treatment without resorting to the use of exogenous insulin can be achieved only with pancreas or islet cell transplantation.
A.N. Balamurugan, Alexander, Allen, Amos, Barber, Barrou, Bartlett, Björk, Bonner-Weir, Brekke, Calne, Calne, Cameron, Cheung, Chow, Corry, Diem, Diem, DiLandro, Fontes, Giannoukakis, Giannoukakis, Gibson, Gliedman, Grey, Groth, Groth, Gu, Gupta, Harris, Hayek, Henry, Ilieva, Kelly, Kemp, Kendall, Kendall, Keymeulen, Kirk, Koike, Koike, Lacy, Lafferty, Lakey, Lillehei, London, Massimo Trucco, Mazariegos, Mintz, Murray, Najarian, Nghiem, Paraskevas, Petruzzo, Piehlmeier, Pipeleers-Marichal, Posselt, Prevost, Rajotte, Ramiya, Ramos, Ricordi, Rita Bottino, Robertson, Shapiro, Simeonovic, Solders, Sollinger, Sollinger, Sollinger, Soria, Ssobolew, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Stone, Stratta, Stratta, Sutherland, Suzuki, Tchervenivanov, Terasaki, Thomas E. Starzl, Tyden, Tzakis, Yasunami   +94 more
core   +1 more source

Clinical Islet Xenotransplantation: Development of Isolation Protocol, Anti-Rejection Strategies, and Clinical Outcomes

Cells
Allogeneic islet transplantation has become a standard therapy for unstable type 1 diabetes. However, considering the large number of type 1 diabetic patients, the shortage of donors is a serious issue.
Shinichi Matsumoto, Kyohei Matsumoto
doaj   +1 more source

Screening donors for xenotransplantation: The potential for xenozoonoses [PDF]

, 1994
Xenotransplantation is a potential solution to the current donor shortage for solid organ transplantation. The transmission of infectious agents from donor organs or bone marrow to the recipient is a well-recognized phenomenon following ...
Kahleen, B, Kalter, S, McMichael, JP, Michaels, MG, Peters, RL, Simmons, RL, Starzl, TE   +6 more
core   +1 more source

The Future of Pig Liver Xenotransplantation

Transplant International
Recent technological advances in genetic engineering have led to a renewed interest in xenotransplantation. Milestones achievements in heart, kidney and more recently liver xenotransplantation raise the hope of an alternative source of organs and pave ...
Ahmad Karadagi, Ahmad Karadagi, Gabriel C. Oniscu, Gabriel C. Oniscu   +3 more
doaj   +1 more source