Results 31 to 40 of about 15,110 (190)
Preliminary Study on Construction Method of Type 1 Diabetes Model in Banna Miniature Pig
Shiyan dongwu yu bijiao yixueObjective To construct a Type 1 diabetes model in miniature pigs and explore postoperative care strategies for effectively prolonging the survival time of the model pigs. Methods Seven Banna miniature pigs were selected for pancreatectomy.
LIU Kai +10 more
doaj +1 more source
Advances in Innate Immunity to Overcome Immune Rejection during Xenotransplantation
Cells, 2022 Transplantation is an effective approach for treating end-stage organ failure. There has been a long-standing interest in xenotransplantation as a means of increasing the number of available organs.
Tian-Yu Lu +6 more
doaj +1 more source
The Ethics of Xenotransplantation [PDF]
Journal of Applied Philosophy, 2000 Xenotransplantation--moving organs or cells from one species to another--is currently being actively researched as a possible contribution to the problem of a global shortage of human organs for transplants. Should xenotransplantation be encouraged, permitted, frowned upon or forbidden?
openaire +4 more sources
Animal Models and Experimental Medicine, EarlyView.Substantial advances have been achieved in the development of humanized mouse models, which have proven highly valuable in evaluating cancer immunotherapies and elucidating the mechanisms of infectious diseases. There is now a growing shift in research toward larger animal models—such as pigs—that offer greater physiological similarity to humans ...
Yanan Lyu, Yong‐Guang Yang, Zheng Hu
wiley +1 more source
Evidence for the important role of inflammation in xenotransplantation
Journal of Inflammation, 2019 There is increasing evidence of a sustained state of systemic inflammation after pig-to-nonhuman primate (NHP) xenotransplantation (that has been termed systemic inflammation in xenograft recipients [SIXR]).
Juan Li +5 more
doaj +1 more source
Ethical issues of xenotransplantation in the aspect of religious views
Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье, 2022 Transplantation allows us to confidently save the lives of previously doomed patients. Unfortunately, this colossal achievement of human progress has a problematic side – the shortage of donor organs. The use of animal organs could solve it.
R. A. Sharifova +4 more
doaj +1 more source
Animal Models and Experimental Medicine, EarlyView.The graphical abstract shows how molecular biology research has shifted from using traditional animal models toward using methods that are more relevant to humans. It points out the main problems, differences between species, difficulty in reproducing results, moral issues, and lack of infrastructure that make translational accuracy harder to achieve ...
Md. Shajid Hossain Rafi +6 more
wiley +1 more source
Xenotransplantation and tolerance [PDF]
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 2001 The application of xenotransplantation faces daunting immunological hurdles, some of which might be overcome with the induction of tolerance. Porcine organs transplanted into primates are subject to several types of rejection responses. Hyperacute rejection mediated by naturally occurring xenoreactive antibodies and complement can be overcome without ...
B, Samstein, J L, Platt
openaire +2 more sources
Characterization of the extracellular matrix from human and dog umbilical cords
The Anatomical Record, EarlyView.Abstract The extracellular matrix is important for maintaining tissue morphogenesis and homeostasis; it can also be used as a biomaterial for the production of biological scaffolds. Particularly, the umbilical cord has shown potential in the production of scaffolds for small‐diameter vessels.
Ana Carla Mendonça +6 more
wiley +1 more source
Unraveling the impact of hyperleptinemia on female reproduction: insights from transgenic pig model
Biological ResearchBackground Infertility is a growing global health concern affecting millions of couples worldwide. Among several factors, an extreme body weight adversely affects reproductive functions. Leptin is a well-known adipokine that serves as an endocrine signal
Muhammad Ameen Jamal +17 more
doaj +1 more source