Results 31 to 40 of about 21,110 (223)

Sensitive detection systems for infectious agents in xenotransplantation*

Xenotransplantation, EarlyView., 2020
Abstract Xenotransplantation of pig cells, tissues, or organs may be associated with transmission of porcine microorganisms, first of all of viruses, to the transplant recipient, potentially inducing a disease (zoonosis). I would like to define detection systems as the complex of sample generation, sample preparation, sample origin, time of sampling ...
Joachim Denner
wiley   +1 more source

Organs from animals for man [PDF]

, 1998
In the following review some of the problems of xenotransplantation shall be discussed, based on the few experimental data available so far and on reports in the literature describing investigations which may be of importance for xenotransplantation. The
Diefenbeck, M., Hammer, C., Wagner, F., Linke, R.   +3 more
core   +1 more source

Evidence for GTKO/β4GalNT2KO Pigs as the Preferred Organ-source for Old World Nonhuman Primates as a Preclinical Model of Xenotransplantation

Transplantation Direct, 2020
Background. Triple-knockout (TKO) pigs (in which expression of the 3 known pig carbohydrate xenoantigens has been deleted) are likely to be an optimal source of organs for transplantation into human recipients, many of whom do not have natural antibodies
Yehua Cui, MD, Takayuki Yamamoto, MD, PhD, Syed Sikandar Raza, BA, Mahmoud Morsi, MD, Huy Quoc Nguyen, BS, David Ayares, PhD, David K.C. Cooper, MD, PhD, Hidetaka Hara, MD, PhD   +7 more
doaj   +1 more source

The history of cardiac xenotransplantation: early attempts, major advances, and current progress

Frontiers in Transplantation, 2023
In light of ongoing shortage of donor organs for transplantation, alternative sources for donor organ sources have been examined to address this supply-demand mismatch.
Nicholas R. Hess, David J. Kaczorowski, David J. Kaczorowski   +2 more
doaj   +1 more source

Liver xenotransplantation [PDF]

Current Opinion in Organ Transplantation, 2017
There continues to be an inadequate organ supply and lack of effective temporary support, for patients with liver failure. The purpose of this review is to discuss recent progress in the field of orthotopic pig-to-nonhuman primate (NHP) liver xenotransplantation (LXT).From 1968 to 2012, survival in pig-to-NHP LXT was limited to 9 days, initially due to
Madhukar S, Patel, Nathan, Louras, Parsia A, Vagefi   +2 more
openaire   +2 more sources

First update of the International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes - Chapter 1: update on national regulatory frameworks pertinent to clinical islet xenotransplantation [PDF]

, 2019
Islet xenotransplantation represents an attractive solution to overcome the shortage of human islets for use in type 1 diabetes. The wide-scale application of clinical islet xenotransplantation, however, requires that such a procedure takes place in a ...
권복규
core   +1 more source

Current status of xenotransplantation and prospects for clinical application [PDF]

, 2020
Xenotransplantation is one promising approach to bridge the gap between available human cells, tissues, and organs and the needs of patients with diabetes or end-stage organ failure.
Ayares, David, Seebach, Jörg D., Fishman, Jay, Hering, Bernhard J., Cooper, David K. C., Dorling, Anthony, Rees, Michael Kenneth, Pierson, Richard N.   +7 more
core   +1 more source

T regulatory cells in xenotransplantation [PDF]

, 2009
The role of T regulatory cells (Treg) in the induction and maintenance of allograft tolerance is being studied to a great extent. In contrast, little is known on their potential to prevent graft rejection in the field of xenotransplantation, where acute ...
Yannick D. Muller, Jörg D. Seebach, Wekerle, Thomas, Muller, Y.D., Wekerle, T., Golshayan, D., Déla Golshayan, Thomas Wekerle, Golshayan, Dela, Ehirchiou, D., Driss Ehirchiou, Seebach, J.D., Leo H. Bühler, Seebach, Jorg Dieter, Muller, Yannick, Bühler, L.H., Ehirchiou, Driss, Buehler, Leo Hans   +17 more
core   +1 more source

Tolerance in xenotransplantation [PDF]

Current Opinion in Organ Transplantation, 2017
This review describes recent progress in tolerance-inducing strategies across xenogeneic immunological barriers as well as the potential benefit of a tolerance strategy for islets and kidney xenotransplantation.Using advanced gene editing technologies, xenotransplantation from multitransgenic alpha-1,3-galactosyltransferase knockout pigs has ...
Kazuhiko, Yamada, Megan, Sykes, David H, Sachs   +2 more
openaire   +2 more sources

Clinical lung xenotransplantation - what donor genetic modifications may be necessary? [PDF]

, 2012
Barriers to successful lung xenotransplantation appear to be even greater than for other organs. This difficulty may be related to several macro anatomic factors, such as the uniquely fragile lung parenchyma and associated blood supply that results in ...
David Ayares, Simon C. Robson, David K. C. Cooper, Carol Phelps, Ekser, Burcin, Burlak, Christopher, Azimzadeh, Agnes M, Ayares, David, Pierson, 3rd, Richard N, Tector, Alfred, Mohamed Ezzelarab, Agnes M. Azimzadeh, Christopher Burlak, Burcin Ekser, Hidetaka Hara, Leela Paris, Tector, A Joseph, Cooper, David K C, A. Joseph Tector, Richard N. Pierson, Paris, Leela, Phelps, Carol, Hara, Hidetaka, Robson, Simon C, Ezzelarab, Mohamed   +24 more
core   +1 more source