Results 31 to 40 of about 23,059 (229)

Development of RAG2-/-IL2Rγ-/Y immune deficient FAH-knockout miniature pig

Frontiers in Immunology, 2022
Human hepatocyte transplantation for liver disease treatment have been hampered by the lack of quality human hepatocytes. Pigs with their large body size, longevity and physiological similarities with human are appropriate animal models for the in vivo ...
Heng Zhao, Heng Zhao, Heng Zhao, Weijian Ye, Weijian Ye, Jianxiong Guo, Jianxiong Guo, Jiaoxiang Wang, Jiaoxiang Wang, Jiaoxiang Wang, Deling Jiao, Deling Jiao, Deling Jiao, Kaixiang Xu, Kaixiang Xu, Kaixiang Xu, Chang Yang, Chang Yang, Shuhan Chen, Shuhan Chen, Shuhan Chen, Muhammad Ameen Jamal, Zhongbin Bai, Taiyun Wei, Taiyun Wei, Jie Cai, Jie Cai, Tien Dat Nguyen, Tien Dat Nguyen, Tien Dat Nguyen, Yubo Qing, Yubo Qing, Yubo Qing, Wenmin Cheng, Wenmin Cheng, Wenmin Cheng, Baoyu Jia, Baoyu Jia, Baoyu Jia, Honghui Li, Honghui Li, Honghui Li, Hong-Ye Zhao, Hong-Ye Zhao, Qingfeng Chen, Qingfeng Chen, Hong-Jiang Wei, Hong-Jiang Wei, Hong-Jiang Wei, Hong-Jiang Wei   +49 more
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Intratracheal inoculation of human varicella zoster virus (VZV; MAV strain) vaccine successfully induced VZV IgG antibodies in rhesus monkeys

Laboratory Animal Research, 2021
Background The objective of this study was to investigate whether the use of live attenuated varicella zoster virus (VZV) MAV vaccination can efficiently induce VZV antibody production in naive rhesus monkeys as an approach to prevent simian varicella ...
Jong-Min Kim, Chung-Gyu Park
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Xenotransplantation

Journal of British Surgery, 2000
Abstract Background The success of clinical transplantation has led to a large discrepancy between donor organ availability and demand; considerable pressure exists to develop an alternative source of organs.
Soin, B, Vial, C, Friend, P
openaire   +3 more sources

Xenotransplantation: Perspectives and limits [PDF]

, 2001
Xenotransplantation faces the dilemma of an unlimited supply of cells, tissues and organs on the one hand and severe obstacles and limits on the other. One reason for the limitations is that the source animal of choice, the pig, and the human recipient ...
Hammer, Claus, Claus Hammer
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Species origin of exogenous transcription factors affects the activation of endogenous pluripotency markers and signaling pathways of porcine induced pluripotent stem cells

Frontiers in Cell and Developmental Biology, 2023
The incomplete silencing of exogenous transcription factors (TFs) and the lack of endogenous counterpart activation hampers the application of porcine induced pluripotent stem cells (piPSCs).
Meng Zhou, Manling Zhang, Tianxu Guo, Lihua Zhao, Lihua Zhao, Xiyun Guo, Zhibao Yin, Linxin Cheng, Han Liu, Lixia Zhao, Xihe Li, Rongfeng Li, Rongfeng Li   +12 more
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Xenotransplantation public perceptions: rather cells than organs. [PDF]

, 2003
The aim of this study was to describe some of the factors that might play a role in influencing attitude to xenotransplantation: first, the consideration of receiving cells and tissue from xenotransplants in relation to whole xeno-organs; secondly, the ...
Ranstam, Jonas, Hermerén, Göran, Persson, Nils H, Persson, Marie Omnell, Lund University., Hermerén, Göran,   +5 more
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Differences in platelet aggregometers to study platelet function and coagulation dysregulation in xenotransplantation

, 2021
Xenotransplantation (ie, cross-species transplantation) using genetically engineered pig organs could be a limitless source to solve the shortage of organs and tissues worldwide.
Burcin Ekser, Yilmaz, Sezai, Li, Ping, Sezai Yilmaz, Isidan, Abdulkadir, Zhang, Wenjun, Angela M. Chen, Saglam, Kutay, Abdulkadir Isidan, Ekser, Burcin, Ping Li, Kutay Saglam, Wenjun Zhang, Chen, Angela M.   +13 more
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Apolipoprotein E deficiency accelerates atherosclerosis development in miniature pigs

Disease Models & Mechanisms, 2018
Miniature pigs have advantages over rodents in modeling atherosclerosis because their cardiovascular system and physiology are similar to that of humans. Apolipoprotein E (ApoE) deficiency has long been implicated in cardiovascular disease in humans.
Bin Fang, Xueyang Ren, Ying Wang, Ze Li, Lihua Zhao, Manling Zhang, Chu Li, Zhengwei Zhang, Lei Chen, Xiaoxue Li, Jiying Liu, Qiang Xiong, Lining Zhang, Yong Jin, Xiaorui Liu, Lin Li, Hong Wei, Haiyuan Yang, Rongfeng Li, Yifan Dai   +19 more
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Kidney xenotransplantation [PDF]

Kidney International, 2014
Xenotransplantation using pigs as donors offers the possibility of eliminating the chronic shortage of donor kidneys, but there are several obstacles to be overcome before this goal can be achieved. Preclinical studies have shown that, while porcine renal xenografts are broadly compatible physiologically, they provoke a complex rejection process ...
Cowan, PJ, Cooper, DKC, d'Apice, AJF
openaire   +3 more sources

Generation of complement protein C3 deficient pigs by CRISPR/Cas9-mediated gene targeting

Scientific Reports, 2017
Complement protein C3 is the pivotal component of the complement system. Previous studies have demonstrated that C3 has implications in various human diseases and exerts profound functions under certain conditions.
Wei Zhang, Guan Wang, Ying Wang, Yong Jin, Lihua Zhao, Qiang Xiong, Lining Zhang, Lisha Mou, Rongfeng Li, Haiyuan Yang, Yifan Dai   +10 more
doaj   +1 more source