Results 11 to 20 of about 23,059 (229)
Organogenesis, 2018 The transplantation of living cells, tissues or organs from one species to another is termed xenotransplantation. The history of xenotransplantation is as old as allogeneic transplantation itself. Early attempts were made at a time when the immunologic basis of organ rejection were poorly understood.
Sundaram Hariharan, Srijan Tandukar
exaly +5 more sources
British Medical Bulletin, 1999 The success of organ transplantation has led to an ever-increasing shortfall between the demand for organs and the supply. This has led to extensive investigation of the possible use of animals, especially the pig, as organ donors. However, a number of major barriers to successful xenotransplantation exist.
L H, McBride +3 more
core +10 more sources
Xenotransplantation: Current Status in Preclinical Research
Frontiers in Immunology, 2020 The increasing life expectancy of humans has led to a growing numbers of patients with chronic diseases and end-stage organ failure. Transplantation is an effective approach for the treatment of end-stage organ failure; however, the imbalance between ...
Chuan Qin
exaly +3 more sources
Recent progress in pig-to-human kidney xenotransplantation
Frontiers in ImmunologyEven though the patient kept up his dialysis regimen as he had before xenotransplantation, this is a significant development for xenotransplantation. This benchmark for xenotransplantation has the following significant findings. Firstly, from the patient’
Kaiyu Zhou
exaly +3 more sources
Correction to "Porcine kidney xenotransplantation: From primate models to clinical reality". [PDF]
Animal Model Exp MedAnimal Models and Experimental Medicine, EarlyView.
europepmc +2 more sources
Current Opinion in Nephrology and Hypertension, 1996 Xenotransplantation of pig organs into humans represents an attractive solution to the worldwide organ shortage. The survival of pig organs in primates has so far primarily been hampered by hyperacute rejection of the xenograft. The immunological mechanisms which underlie hyperacute rejection have recently been clarified.
Cozzi E., White D. J. G.
openaire +4 more sources
Life, 2021 The base editing 3 (BE3) system, a single-base gene editing technology developed using CRISPR/Cas9n, has a broad range of applications for human disease model construction and gene therapy, as it is highly efficient, accurate, and non-destructive.
Honghui Li +13 more
doaj +1 more source
Artificial Intelligence in Xenotransplantation: A Prioritized Roadmap for Early Clinical Translation, Opportunities and Challenges. [PDF]
XenotransplantationABSTRACT Xenotransplantation represents a potential solution to the persistent global organ shortage, yet its clinical application remains stalled by complex immunologic responses, coagulation dysregulation, species‐specific biology, and infectious risks.
Shirini K +7 more
europepmc +2 more sources
Construction of PIK3C3 Transgenic Pig and Its Pathogenesis of Liver Damage
Life, 2022 As a member of the PIKs family, PIK3C3 participates in autophagy and plays a central role in liver function. Several studies demonstrated that the complete suppression of PIK3C3 in mammals can cause hepatomegaly and hepatosteatosis. However, the function
Jing Wang +19 more
doaj +1 more source
Blastocyst Complementation: The New Kid on the Xenotransplantation Block. [PDF]
XenotransplantationABSTRACT The transplantation of genetically modified pig organs and tissues is arguably the most promising approach to overcoming the world‐wide shortage of organ and tissues for transplantation. The advent of gene editing has seen a resurgence in interest in this approach which has also allowed blastocyst complementation to be explored as an ...
Nottle MB, Cowan PJ, Hawthorne WJ.
europepmc +2 more sources