Results 11 to 20 of about 15,793 (179)

Corneal Xenotransplantation: Lessons From Allograft Immunobiology and Emerging Translational Strategies [PDF]

Xenotransplantation, Volume 33, Issue 6, November/December 2026.
ABSTRACT Corneal transplantation is an effective sight‐restoring procedure, yet its global impact remains constrained by limited and uneven access to human donor tissue and by immune‐mediated graft failure, particularly in high‐risk recipients. Xenotransplantation offers a potentially scalable alternative, but successful clinical translation requires ...
Ansu A. John, Ellen H. Koo
wiley   +2 more sources

Reframing Technology and Ethics in Corneal Xenotransplantation: A Scoping Review of Standards and Safety in Ophthalmology [PDF]

Health Care Science, EarlyView.
Bringing attention to the moral dilemmas raised by xenotransplantation and the continuous creation of standardized frameworks for donor technology and biosafety risk management, with a focus on striking a balance between patient safety, medical innovation, and ethical obligation.
Sankhajyoti Saha, Moubani Dutta, Agnihiya Bosu   +2 more
wiley   +2 more sources

Public awareness and acceptance of xenotransplantation in China: a cross-sectional survey [PDF]

BMC Medical Ethics
Background Xenotransplantation using genetically edited pig organs has been considered a promising solution to the global organ shortage. However, its successful implementation depends not only on scientific advance but also on public acceptance ...
Jing Wen, Haoran Li, Di Wang, Mingtao Huang, Xiaomei Zhai   +4 more
doaj   +2 more sources

Xenotransplantation [PDF]

British Medical Bulletin, 1999
The success of organ transplantation has led to an ever-increasing shortfall between the demand for organs and the supply. This has led to extensive investigation of the possible use of animals, especially the pig, as organ donors. However, a number of major barriers to successful xenotransplantation exist.
L H, McBride, R M, Taylor, R H, Hogarth, K M, Kinter   +3 more
  +10 more sources

Xenotransplantation [PDF]

Journal of Internal Medicine, 1996
Kemp E (Department of Nephrology, Odense University Hospital, Odense, Denmark). Xenotransplantation (Review). J Intern Med 1996; 239: 287–97.Xenotransplantation means transplantation of organs and tissues from animals to human beings. Today, with use of new and more conventional immunosuppressive substances, it is possible to achieve good long‐term ...
Cozzi E., White D. J. G.
openaire   +4 more sources

Efficient Generation of P53 Biallelic Mutations in Diannan Miniature Pigs Using RNA-Guided Base Editing

Life, 2021
The base editing 3 (BE3) system, a single-base gene editing technology developed using CRISPR/Cas9n, has a broad range of applications for human disease model construction and gene therapy, as it is highly efficient, accurate, and non-destructive.
Honghui Li, Wenmin Cheng, Bowei Chen, Shaoxia Pu, Ninglin Fan, Xiaolin Zhang, Deling Jiao, Dejia Shi, Jianxiong Guo, Zhuo Li, Yubo Qing, Baoyu Jia, Hong-Ye Zhao, Hong-Jiang Wei   +13 more
doaj   +1 more source

Construction of PIK3C3 Transgenic Pig and Its Pathogenesis of Liver Damage

Life, 2022
As a member of the PIKs family, PIK3C3 participates in autophagy and plays a central role in liver function. Several studies demonstrated that the complete suppression of PIK3C3 in mammals can cause hepatomegaly and hepatosteatosis. However, the function
Jing Wang, Sami Ullah Khan, Pan Cao, Xi Chen, Fengchong Wang, Di Zou, Honghui Li, Heng Zhao, Kaixiang Xu, Deling Jiao, Chang Yang, Feiyan Zhu, Yaxuan Zhang, Yanhua Su, Wenmin Cheng, Baoyu Jia, Yubo Qing, Muhammad Ameen Jamal, Hong-Ye Zhao, Hong-Jiang Wei   +19 more
doaj   +1 more source

Development of a Lung Vacancy Mouse Model through CRISPR/Cas9-Mediated Deletion of Thyroid Transcription Factor 1 Exon 2

Cells, 2022
A developmental niche vacancy in host embryos is necessary for stem cell complementation-based organ regeneration (SCOG). Thyroid transcription factor 1 (TTF-1) is a tissue-specific transcription factor that regulates the embryonic development and ...
Lihua Zhao, Meishuang Li, Zhibao Yin, Limin Lv, Meng Zhou, Yixi Wang, Manling Zhang, Tianxu Guo, Xiyun Guo, Han Liu, Linxin Cheng, Xiubin Liang, Shuguang Duo, Rongfeng Li   +13 more
doaj   +1 more source

TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk

Hepatology, EarlyView., 2022
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam, Jianqing Yu, Hao Huang, Xiaofan Ding, Alissa M. Wong, Howard H. Leung, Anthony W. Chan, Kelvin K. Ng, Mingjing Xu, Xin Wang, Nathalie Wong   +10 more
wiley   +1 more source

Small Ruminant Farming in Tribal Areas of Dera Ghazi Khan, Punjab, Pakistan

Veterinary Sciences, 2022
Provincially Administered Tribal Areas (PATA) of Punjab-Pakistan are comprised of hilly mountains with small ruminants as a sole source of income. In this study, farming practices, productivity, health and the economic value of sheep were evaluated in ...
Muhammad Ameen Jamal, Samiullah Khan, Yanhua Su, Chang Yang, Heng Zhao, Kaixiang Xu, Deling Jiao, Wenmin Cheng, Abdul Rauf, Mahboob Ali, Sohail Ahmad, Yubo Qing, Hong-Jiang Wei   +12 more
doaj   +1 more source