Results 11 to 20 of about 15,110 (190)

Recent progress in pig-to-human kidney xenotransplantation [PDF]

Frontiers in Immunology
Even though the patient kept up his dialysis regimen as he had before xenotransplantation, this is a significant development for xenotransplantation. This benchmark for xenotransplantation has the following significant findings. Firstly, from the patient’
Pei Tao, Pei Tao, Kaiyu Zhou
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Intratracheal inoculation of human varicella zoster virus (VZV; MAV strain) vaccine successfully induced VZV IgG antibodies in rhesus monkeys

Laboratory Animal Research, 2021
Background The objective of this study was to investigate whether the use of live attenuated varicella zoster virus (VZV) MAV vaccination can efficiently induce VZV antibody production in naive rhesus monkeys as an approach to prevent simian varicella ...
Jong-Min Kim, Chung-Gyu Park
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Establishment of PIN1 knockout porcine fetal fibroblast cell lines via CRISPR/Cas9 mediated gene-targeting

陆军军医大学学报, 2022
Objective To knock out PIN1 gene of porcine fetal fibroblasts (PFFs) by clustered regular interval short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) system in order to establish PIN1 knockout porcine fetal fibroblast cell lines ...
WANG Wanyi, YUAN Yilin, LI Lin, WANG Ying, DAI Yifan, YANG Haiyuan   +5 more
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Development of RAG2-/-IL2Rγ-/Y immune deficient FAH-knockout miniature pig

Frontiers in Immunology, 2022
Human hepatocyte transplantation for liver disease treatment have been hampered by the lack of quality human hepatocytes. Pigs with their large body size, longevity and physiological similarities with human are appropriate animal models for the in vivo ...
Heng Zhao, Heng Zhao, Heng Zhao, Weijian Ye, Weijian Ye, Jianxiong Guo, Jianxiong Guo, Jiaoxiang Wang, Jiaoxiang Wang, Jiaoxiang Wang, Deling Jiao, Deling Jiao, Deling Jiao, Kaixiang Xu, Kaixiang Xu, Kaixiang Xu, Chang Yang, Chang Yang, Shuhan Chen, Shuhan Chen, Shuhan Chen, Muhammad Ameen Jamal, Zhongbin Bai, Taiyun Wei, Taiyun Wei, Jie Cai, Jie Cai, Tien Dat Nguyen, Tien Dat Nguyen, Tien Dat Nguyen, Yubo Qing, Yubo Qing, Yubo Qing, Wenmin Cheng, Wenmin Cheng, Wenmin Cheng, Baoyu Jia, Baoyu Jia, Baoyu Jia, Honghui Li, Honghui Li, Honghui Li, Hong-Ye Zhao, Hong-Ye Zhao, Qingfeng Chen, Qingfeng Chen, Hong-Jiang Wei, Hong-Jiang Wei, Hong-Jiang Wei, Hong-Jiang Wei   +49 more
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AMPK attenuates SHH subgroup medulloblastoma growth and metastasis by inhibiting NF-κB activation

Cell & Bioscience, 2023
Background Medulloblastoma (MB) is one of the most common malignant pediatric brain tumors. Metastasis and relapse are the leading causes of death in MB patients.
Jing Cai, Yue Wang, Xinfa Wang, Zihe Ai, Tianyuan Li, Xiaohong Pu, Xin Yang, Yixing Yao, Junping He, Steven Y. Cheng, Tingting Yu, Chen Liu, Shen Yue   +12 more
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Species origin of exogenous transcription factors affects the activation of endogenous pluripotency markers and signaling pathways of porcine induced pluripotent stem cells

Frontiers in Cell and Developmental Biology, 2023
The incomplete silencing of exogenous transcription factors (TFs) and the lack of endogenous counterpart activation hampers the application of porcine induced pluripotent stem cells (piPSCs).
Meng Zhou, Manling Zhang, Tianxu Guo, Lihua Zhao, Lihua Zhao, Xiyun Guo, Zhibao Yin, Linxin Cheng, Han Liu, Lixia Zhao, Xihe Li, Rongfeng Li, Rongfeng Li   +12 more
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Apolipoprotein E deficiency accelerates atherosclerosis development in miniature pigs

Disease Models & Mechanisms, 2018
Miniature pigs have advantages over rodents in modeling atherosclerosis because their cardiovascular system and physiology are similar to that of humans. Apolipoprotein E (ApoE) deficiency has long been implicated in cardiovascular disease in humans.
Bin Fang, Xueyang Ren, Ying Wang, Ze Li, Lihua Zhao, Manling Zhang, Chu Li, Zhengwei Zhang, Lei Chen, Xiaoxue Li, Jiying Liu, Qiang Xiong, Lining Zhang, Yong Jin, Xiaorui Liu, Lin Li, Hong Wei, Haiyuan Yang, Rongfeng Li, Yifan Dai   +19 more
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Kidney xenotransplantation [PDF]

Kidney International, 2014
Xenotransplantation using pigs as donors offers the possibility of eliminating the chronic shortage of donor kidneys, but there are several obstacles to be overcome before this goal can be achieved. Preclinical studies have shown that, while porcine renal xenografts are broadly compatible physiologically, they provoke a complex rejection process ...
Cowan, PJ, Cooper, DKC, d'Apice, AJF
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Generation of complement protein C3 deficient pigs by CRISPR/Cas9-mediated gene targeting

Scientific Reports, 2017
Complement protein C3 is the pivotal component of the complement system. Previous studies have demonstrated that C3 has implications in various human diseases and exerts profound functions under certain conditions.
Wei Zhang, Guan Wang, Ying Wang, Yong Jin, Lihua Zhao, Qiang Xiong, Lining Zhang, Lisha Mou, Rongfeng Li, Haiyuan Yang, Yifan Dai   +10 more
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Xenotransplantation

Journal of British Surgery, 2000
Abstract Background The success of clinical transplantation has led to a large discrepancy between donor organ availability and demand; considerable pressure exists to develop an alternative source of organs.
Soin, B, Vial, C, Friend, P
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