Results 11 to 20 of about 21,110 (223)
Production of Triple-Gene (GGTA1, B2M and CIITA)-Modified Donor Pigs for Xenotransplantation
Frontiers in Veterinary Science, 2022 Activation of human immune T-cells by swine leukocyte antigens class I (SLA-I) and class II (SLA-II) leads to xenograft destruction. Here, we generated the GGTA1, B2M, and CIITA (GBC) triple-gene-modified Diannan miniature pigs, analyzed the ...
Kaixiang Xu +43 more
doaj +1 more source
The Swiss Technology Assessment Project on Xenotransplantation [PDF]
, 2022 S.155-165The Swiss Technology Assessment (TA) project on xenotransplantation is intended to study the opportunities and risks of this technique, recognizing the input of those involved in and those affected by it.
Rüegsegger, A. +3 more
core +1 more source
Immunogenetics of xenotransplantation [PDF]
International Journal of Immunogenetics, 2021 AbstractXenotransplantation may become the highly desired solution to close the gap between the availability of donated organs and number of patients on the waiting list. In recent years, enormous progress has been made in the development of genetically engineered donor pigs.
Marco Carvalho‐Oliveira +3 more
openaire +2 more sources
Health sciences students and their attitude toward islet xenotransplantation for diabetes: a multicenter stratified study from Spain [PDF]
, 2019 Health sciences students and their attitude toward islet xenotransplantation for diabetes: a multicenter stratified study from ...
Santainés Borredá, Elena +2 more
core +7 more sources
陆军军医大学学报, 2022 Objective To knock out PIN1 gene of porcine fetal fibroblasts (PFFs) by clustered regular interval short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) system in order to establish PIN1 knockout porcine fetal fibroblast cell lines ...
WANG Wanyi +5 more
doaj +1 more source
Laboratory Animal Research, 2021 Background The objective of this study was to investigate whether the use of live attenuated varicella zoster virus (VZV) MAV vaccination can efficiently induce VZV antibody production in naive rhesus monkeys as an approach to prevent simian varicella ...
Jong-Min Kim, Chung-Gyu Park
doaj +1 more source
Development of RAG2-/-IL2Rγ-/Y immune deficient FAH-knockout miniature pig
Frontiers in Immunology, 2022 Human hepatocyte transplantation for liver disease treatment have been hampered by the lack of quality human hepatocytes. Pigs with their large body size, longevity and physiological similarities with human are appropriate animal models for the in vivo ...
Heng Zhao +49 more
doaj +1 more source
AMPK attenuates SHH subgroup medulloblastoma growth and metastasis by inhibiting NF-κB activation
Cell & Bioscience, 2023 Background Medulloblastoma (MB) is one of the most common malignant pediatric brain tumors. Metastasis and relapse are the leading causes of death in MB patients.
Jing Cai +12 more
doaj +1 more source
Xenotransplantation-associated infectious risk: a WHO consultation [PDF]
, 2020 Xenotransplantation carries the potential risk of the transmission of infection with the cells or tissues of the graft. The degree of risk is unknown in the absence of clinical trials.
Scobie, Linda +2 more
core +1 more source
Xenotransplantation: Perspectives and limits [PDF]
, 2001 Xenotransplantation faces the dilemma of an unlimited supply of cells, tissues and organs on the one hand and severe obstacles and limits on the other. One reason for the limitations is that the source animal of choice, the pig, and the human recipient ...
Hammer, Claus
core +1 more source