Results 21 to 30 of about 15,110 (190)

The history of cardiac xenotransplantation: early attempts, major advances, and current progress

Frontiers in Transplantation, 2023
In light of ongoing shortage of donor organs for transplantation, alternative sources for donor organ sources have been examined to address this supply-demand mismatch.
Nicholas R. Hess, David J. Kaczorowski, David J. Kaczorowski   +2 more
doaj   +1 more source

Evidence for GTKO/β4GalNT2KO Pigs as the Preferred Organ-source for Old World Nonhuman Primates as a Preclinical Model of Xenotransplantation

Transplantation Direct, 2020
Background. Triple-knockout (TKO) pigs (in which expression of the 3 known pig carbohydrate xenoantigens has been deleted) are likely to be an optimal source of organs for transplantation into human recipients, many of whom do not have natural antibodies
Yehua Cui, MD, Takayuki Yamamoto, MD, PhD, Syed Sikandar Raza, BA, Mahmoud Morsi, MD, Huy Quoc Nguyen, BS, David Ayares, PhD, David K.C. Cooper, MD, PhD, Hidetaka Hara, MD, PhD   +7 more
doaj   +1 more source

Liver xenotransplantation [PDF]

Current Opinion in Organ Transplantation, 2017
There continues to be an inadequate organ supply and lack of effective temporary support, for patients with liver failure. The purpose of this review is to discuss recent progress in the field of orthotopic pig-to-nonhuman primate (NHP) liver xenotransplantation (LXT).From 1968 to 2012, survival in pig-to-NHP LXT was limited to 9 days, initially due to
Madhukar S, Patel, Nathan, Louras, Parsia A, Vagefi   +2 more
openaire   +2 more sources

Sensitive detection systems for infectious agents in xenotransplantation*

Xenotransplantation, EarlyView., 2020
Abstract Xenotransplantation of pig cells, tissues, or organs may be associated with transmission of porcine microorganisms, first of all of viruses, to the transplant recipient, potentially inducing a disease (zoonosis). I would like to define detection systems as the complex of sample generation, sample preparation, sample origin, time of sampling ...
Joachim Denner
wiley   +1 more source

Tolerance in xenotransplantation [PDF]

Current Opinion in Organ Transplantation, 2017
This review describes recent progress in tolerance-inducing strategies across xenogeneic immunological barriers as well as the potential benefit of a tolerance strategy for islets and kidney xenotransplantation.Using advanced gene editing technologies, xenotransplantation from multitransgenic alpha-1,3-galactosyltransferase knockout pigs has ...
Kazuhiko, Yamada, Megan, Sykes, David H, Sachs   +2 more
openaire   +2 more sources

Construction and Functional Validation of GTKO/hCD55 Gene-Edited Xenotransplant Donor Pigs

Shiyan dongwu yu bijiao yixue
Objective To develop GTKO (α-1,3-galactosyltransferase gene-knockout, GTKO)/hCD55 (human CD55) gene-edited xenotransplant donor pigs and verify their function. Methods In this study, CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9
WANG Jiaoxiang, ZHANG Lu, CHEN Shuhan, JIAO Deling, ZHAO Heng, WEI Taiyun, GUO Jianxiong, XU Kaixiang, WEI Hongjiang   +8 more
doaj   +1 more source

Xenotransplantation: Current Status in Preclinical Research

Frontiers in Immunology, 2020
The increasing life expectancy of humans has led to a growing numbers of patients with chronic diseases and end-stage organ failure. Transplantation is an effective approach for the treatment of end-stage organ failure; however, the imbalance between ...
Tianyu Lu, Tianyu Lu, Tianyu Lu, Bochao Yang, Bochao Yang, Bochao Yang, Ruolin Wang, Ruolin Wang, Ruolin Wang, Chuan Qin, Chuan Qin, Chuan Qin   +11 more
doaj   +1 more source

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

Generation and characterization of genetically modified pigs with GGTA1/β4GalNT2/CMAH knockout and human CD55/CD47 expression for xenotransfusion studies

Scientific Reports
Pig red blood cells (pRBCs) represent a promising alternative to address the shortage in transfusion medicine. Nonetheless, a major obstacle to their clinical implementation is immunological rejection.
Bin Fang, Chunting Wang, Yilin Yuan, Xiaorui Liu, Lili Shi, Lin Li, Ying Wang, Yifan Dai, Haiyuan Yang   +8 more
doaj   +1 more source

Engraftment of sheep splenic lymphocytes into NBSGW mice and application in Brucella infection

Animal Models and Experimental Medicine, EarlyView.
A sheep splenocyte‐reconstituted mouse model (Sh‐Spl mice) was established via intravenous injection of sheep splenic lymphocytes into immunodeficient mice to evaluate Brucella infection. Abstract Background The development of immune reconstituted xenograft mouse models has addressed the limitations imposed by interspecies immunological differences in ...
Xiaowei Wang, Shicheng Wan, Yanmin Guo, Hongyu Han, Fei Luo, Dongmei Jiang, Xiaorong Yang, Quanhai Pang, Haisheng Yu, Jinlian Hua   +9 more
wiley   +1 more source