Results 21 to 30 of about 15,793 (179)
Production of Triple-Gene (GGTA1, B2M and CIITA)-Modified Donor Pigs for Xenotransplantation
Frontiers in Veterinary Science, 2022 Activation of human immune T-cells by swine leukocyte antigens class I (SLA-I) and class II (SLA-II) leads to xenograft destruction. Here, we generated the GGTA1, B2M, and CIITA (GBC) triple-gene-modified Diannan miniature pigs, analyzed the ...
Kaixiang Xu +43 more
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Immunogenetics of xenotransplantation [PDF]
International Journal of Immunogenetics, 2021 Abstract Xenotransplantation may become the highly desired solution to close the gap between the availability of donated organs and number of patients on the waiting list. In recent years, enormous progress has been made in the development of genetically engineered donor pigs.
Marco Carvalho‐Oliveira +3 more
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AMPK attenuates SHH subgroup medulloblastoma growth and metastasis by inhibiting NF-κB activation
Cell & Bioscience, 2023 Background Medulloblastoma (MB) is one of the most common malignant pediatric brain tumors. Metastasis and relapse are the leading causes of death in MB patients.
Jing Cai +12 more
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陆军军医大学学报, 2022 Objective To knock out PIN1 gene of porcine fetal fibroblasts (PFFs) by clustered regular interval short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) system in order to establish PIN1 knockout porcine fetal fibroblast cell lines ...
WANG Wanyi +5 more
doaj +1 more source
Development of RAG2-/-IL2Rγ-/Y immune deficient FAH-knockout miniature pig
Frontiers in Immunology, 2022 Human hepatocyte transplantation for liver disease treatment have been hampered by the lack of quality human hepatocytes. Pigs with their large body size, longevity and physiological similarities with human are appropriate animal models for the in vivo ...
Heng Zhao +49 more
doaj +1 more source
Laboratory Animal Research, 2021 Background The objective of this study was to investigate whether the use of live attenuated varicella zoster virus (VZV) MAV vaccination can efficiently induce VZV antibody production in naive rhesus monkeys as an approach to prevent simian varicella ...
Jong-Min Kim, Chung-Gyu Park
doaj +1 more source
Organogenesis, 2018 The transplantation of living cells, tissues or organs from one species to another is termed xenotransplantation. The history of xenotransplantation is as old as allogeneic transplantation itself. Early attempts were made at a time when the immunologic basis of organ rejection were poorly understood.
Srijan, Tandukar, Sundaram, Hariharan
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Frontiers in Cell and Developmental Biology, 2023 The incomplete silencing of exogenous transcription factors (TFs) and the lack of endogenous counterpart activation hampers the application of porcine induced pluripotent stem cells (piPSCs).
Meng Zhou +12 more
doaj +1 more source
Apolipoprotein E deficiency accelerates atherosclerosis development in miniature pigs
Disease Models & Mechanisms, 2018 Miniature pigs have advantages over rodents in modeling atherosclerosis because their cardiovascular system and physiology are similar to that of humans. Apolipoprotein E (ApoE) deficiency has long been implicated in cardiovascular disease in humans.
Bin Fang +19 more
doaj +1 more source
Kidney xenotransplantation [PDF]
Kidney International, 2014 Xenotransplantation using pigs as donors offers the possibility of eliminating the chronic shortage of donor kidneys, but there are several obstacles to be overcome before this goal can be achieved. Preclinical studies have shown that, while porcine renal xenografts are broadly compatible physiologically, they provoke a complex rejection process ...
Cowan, PJ, Cooper, DKC, d'Apice, AJF
openaire +3 more sources