Results 21 to 30 of about 23,059 (229)

Lebanese medical students’ knowledge on and attitude toward xenotransplantation and its ethical issues: A cross‐sectional study [PDF]

, 2022
Introduction: Xenotransplantation is the transplantation of animal parts into humans. This study's aim is to assess the Lebanese medical students’ attitude toward xenotransplantation and their knowledge of its related ethical issues.
Mokled, Elie, Thea Kaady, Safi, Steven, Mansour, Perla C., Salameh, Pascale R., Perla C. Mansour, El Kareh, Antonio, Kaady, Théa, Steven Safi, Pascale Salameh, Elie Mokled, Antonio El Kareh   +11 more
core   +1 more source

Development of a Lung Vacancy Mouse Model through CRISPR/Cas9-Mediated Deletion of Thyroid Transcription Factor 1 Exon 2

Cells, 2022
A developmental niche vacancy in host embryos is necessary for stem cell complementation-based organ regeneration (SCOG). Thyroid transcription factor 1 (TTF-1) is a tissue-specific transcription factor that regulates the embryonic development and ...
Lihua Zhao, Meishuang Li, Zhibao Yin, Limin Lv, Meng Zhou, Yixi Wang, Manling Zhang, Tianxu Guo, Xiyun Guo, Han Liu, Linxin Cheng, Xiubin Liang, Shuguang Duo, Rongfeng Li   +13 more
doaj   +1 more source

Production of Triple-Gene (GGTA1, B2M and CIITA)-Modified Donor Pigs for Xenotransplantation

Frontiers in Veterinary Science, 2022
Activation of human immune T-cells by swine leukocyte antigens class I (SLA-I) and class II (SLA-II) leads to xenograft destruction. Here, we generated the GGTA1, B2M, and CIITA (GBC) triple-gene-modified Diannan miniature pigs, analyzed the ...
Kaixiang Xu, Kaixiang Xu, Kaixiang Xu, Honghao Yu, Shuhan Chen, Shuhan Chen, Shuhan Chen, Yaxuan Zhang, Yaxuan Zhang, Yaxuan Zhang, Jianxiong Guo, Jianxiong Guo, Chang Yang, Chang Yang, Deling Jiao, Deling Jiao, Deling Jiao, Tien Dat Nguyen, Tien Dat Nguyen, Tien Dat Nguyen, Heng Zhao, Heng Zhao, Heng Zhao, Jiaoxiang Wang, Jiaoxiang Wang, Jiaoxiang Wang, Taiyun Wei, Taiyun Wei, Honghui Li, Honghui Li, Honghui Li, Baoyu Jia, Baoyu Jia, Baoyu Jia, Muhammad Ameen Jamal, Muhammad Ameen Jamal, Muhammad Ameen Jamal, Hong-Ye Zhao, Hong-Ye Zhao, Xingxu Huang, Hong-Jiang Wei, Hong-Jiang Wei, Hong-Jiang Wei, Hong-Jiang Wei   +43 more
doaj   +1 more source

Reframing Technology and Ethics in Corneal Xenotransplantation: A Scoping Review of Standards and Safety in Ophthalmology [PDF]

Health Care Sci
Bringing attention to the moral dilemmas raised by xenotransplantation and the continuous creation of standardized frameworks for donor technology and biosafety risk management, with a focus on striking a balance between patient safety, medical innovation, and ethical obligation.
Saha S, Dutta M, Bosu A.
europepmc   +2 more sources

Small Ruminant Farming in Tribal Areas of Dera Ghazi Khan, Punjab, Pakistan

Veterinary Sciences, 2022
Provincially Administered Tribal Areas (PATA) of Punjab-Pakistan are comprised of hilly mountains with small ruminants as a sole source of income. In this study, farming practices, productivity, health and the economic value of sheep were evaluated in ...
Muhammad Ameen Jamal, Samiullah Khan, Yanhua Su, Chang Yang, Heng Zhao, Kaixiang Xu, Deling Jiao, Wenmin Cheng, Abdul Rauf, Mahboob Ali, Sohail Ahmad, Yubo Qing, Hong-Jiang Wei   +12 more
doaj   +1 more source

Cellular Dynamics of Transgenic Porcine Endothelial Cells to Inflammatory Stimuli in Xenotransplantation Settings. [PDF]

Xenotransplantation
Inflammatory responses have been shown to contribute significantly to the rejection of grafts in both allo- and xenotransplantation. In particular, they play a pivotal role in promoting endothelial activation, complement deposition, and thrombosis ...
Gultom M, Thomi N, Teixeira-Riberio K, Shaw J, Despont A, Klymiuk N, Kemter E, Wolf E, Rieben R.   +8 more
europepmc   +2 more sources

TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk

Hepatology, EarlyView., 2022
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam, Jianqing Yu, Hao Huang, Xiaofan Ding, Alissa M. Wong, Howard H. Leung, Anthony W. Chan, Kelvin K. Ng, Mingjing Xu, Xin Wang, Nathalie Wong   +10 more
wiley   +1 more source

Establishment of PIN1 knockout porcine fetal fibroblast cell lines via CRISPR/Cas9 mediated gene-targeting

陆军军医大学学报, 2022
Objective To knock out PIN1 gene of porcine fetal fibroblasts (PFFs) by clustered regular interval short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) system in order to establish PIN1 knockout porcine fetal fibroblast cell lines ...
WANG Wanyi, YUAN Yilin, LI Lin, WANG Ying, DAI Yifan, YANG Haiyuan   +5 more
doaj   +1 more source

Immunogenetics of xenotransplantation [PDF]

International Journal of Immunogenetics, 2021
AbstractXenotransplantation may become the highly desired solution to close the gap between the availability of donated organs and number of patients on the waiting list. In recent years, enormous progress has been made in the development of genetically engineered donor pigs.
Marco Carvalho‐Oliveira, Emilio Valdivia, Rainer Blasczyk, Constanca Figueiredo   +3 more
openaire   +2 more sources

AMPK attenuates SHH subgroup medulloblastoma growth and metastasis by inhibiting NF-κB activation

Cell & Bioscience, 2023
Background Medulloblastoma (MB) is one of the most common malignant pediatric brain tumors. Metastasis and relapse are the leading causes of death in MB patients.
Jing Cai, Yue Wang, Xinfa Wang, Zihe Ai, Tianyuan Li, Xiaohong Pu, Xin Yang, Yixing Yao, Junping He, Steven Y. Cheng, Tingting Yu, Chen Liu, Shen Yue   +12 more
doaj   +1 more source