Results 11 to 20 of about 2,006 (151)

CMAH Coding Sequence Variants in 15 Non-Domestic Felid Species Related to ABC Blood Group System [PDF]

Animals
Different blood group systems have been characterized in people and other mammals. In domestic cats, the ABC blood group system plays the most important clinical role and has been investigated extensively—from the phenotype to the molecular genetics.
Alexandra Kehl, Henrike Kuder, Lily Parkinson, Amie Koenig, Ines Langbein-Detsch, Elisabeth Mueller, Urs Giger   +6 more
doaj   +3 more sources

Rational Design of Maleic Anhydride Grafted Ethylene/1‐Octene Modifier Systems for Polyamide 6 Impact Modification

Macromolecular Materials and Engineering
This study presents a rational design strategy for ternary polyamide 6 (PA6) compounds impact‐modified with ethylene/1‐octene copolymers (EOR), optimizing mechanical properties, processability, and sustainability.
Abdul Kadir Deeb, Oliver Neuß, Silke Rathgeber   +2 more
doaj   +2 more sources

Cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) mutations associated with the domestic cat AB blood group [PDF]

BMC Genetics, 2007
Background The cat has one common blood group with two major serotypes, blood type A that is dominant to type B. A rare type AB may also be allelic and is suspected to be recessive to A and dominant to B.
Millon Lee V, Pedersen Niels C, Grahn Robert A, Niini Tirri, Bighignoli Barbara, Polli Michele, Longeri Maria, Lyons Leslie A   +7 more
doaj   +2 more sources

N-Glycolylneuraminic Acid (Neu5Gc) Null Large Animals by Targeting the CMP-Neu5Gc Hydroxylase (CMAH)

Frontiers in Immunology, 2019
The two major sialic acids described in mammalian cells are the N-glycolylneuraminic acid (Neu5Gc) and the N-acetylneuraminic acid (Neu5Ac). Neu5Gc synthesis starts from the N-acetylneuraminic acid (Neu5Ac) precursor modified by an hydroxylic group ...
Cesare Galli, Andrea Perota
exaly   +3 more sources

Modern xenotransplantation: rewiring glycan-mediated immunogenicity via genome-glycome convergence [PDF]

EBioMedicine
Summary: Xenotransplantation addresses global organ shortages but faces species-specific glycan antigen barriers. Dominant xenoantigens (α-Gal, Neu5Gc, Sda) trigger hyperacute rejection via antibody-mediated immune cascades, complement activation, and ...
Mingshuo Wang, Qing Wang, Yakun Liu, Jiatong Xu, Yuxin Su, Hui Bai, Yunfang Wang, Jiahong Dong   +7 more
doaj   +2 more sources

Generation of Cloned Sheep Lacking Galactose-α1,3-Galactose and N-Glycolylneuraminic Acid Antigens. [PDF]

Xenotransplantation
ABSTRACT Livestock have long been regarded as a potential source of donor organs to alleviate the global organ shortage for transplantation. Sheep have a similar anatomy to humans, providing the standard model for demonstrating biocompatibility and performance of biological heart valves to obtain regulatory approval for their use in transplantation ...
Appleby SJ, Fermin LM, McLean ZL, Delaney S, Wagner S, Genova CD, Wei J, Meng F, Wells DN, Oback B.   +9 more
europepmc   +2 more sources

Porcine Expanded Potential Stem Cells as a Versatile Platform for Multiplex Genome Editing and Immunophenotyping in Xenotransplantation. [PDF]

Xenotransplantation
ABSTRACT Xenotransplantation utilizing pig donors offers a promising solution to organ shortages, but immune incompatibilities across species remain a major challenge. Current reliance on porcine primary fibroblasts for genome editing is limited by low inefficiency in complex gene editing and difficulties in immunophenotyping edited cells.
Xuan Y, Xiang Y, Wang X, Petersen B, Liu P.   +4 more
europepmc   +2 more sources

The generation and evaluation of TKO/hCD55/hTM/hEPCR gene-modified pigs for clinical organ xenotransplantation [PDF]

Frontiers in Immunology
IntroductionGenetically edited pigs, modified using CRISPR-Cas9 technology, hold promise as potential sources for xenotransplantation. However, the optimal combination of genetic modifications and their expression levels for initial clinical trials ...
Guoli Huai, Yong Wang, Jiaxiang Du, Zhenhui Cheng, Yuxuan Xie, Jia Zhou, Hongmei Tang, Yanyan Jiang, Xiangyang Xing, Shaoping Deng, Dengke Pan, Dengke Pan, Dengke Pan   +12 more
doaj   +2 more sources

CMAH-Targeted Knock-In of Inducible Heme Oxygenase-1 and Constitutive CD47 in GGTA1-Knockout Pigs for Xenotransplantation. [PDF]

Xenotransplantation
ABSTRACT Background Pig xenografts offer a solution to human organ shortage; however, immune rejection is a major barrier. Immunomodulatory genes such as heme oxygenase‐1 (HO1) and CD47 are key. Precise promoter control and strategic genomic integration for reliable expression and xenoantigen disruption are critical.
Lee H, Kim SE, Lee WK, Oh M, Lee S, No JG, Park MR, Kim S, Do MH, Oh KB.   +9 more
europepmc   +2 more sources

Genetic knockout of porcine GGTA1 or CMAH/GGTA1 is associated with the emergence of neo-glycans

, 2023
Background: Pig-derived tissues could overcome the shortage of human donor organs in transplantation. However, the glycans with terminal α-Gal and Neu5Gc, which are synthesized by enzymes, encoded by the genes GGTA1 and CMAH, are known to play a major ...
Dietmar Böthig (21606075), Björn Petersen (207895), Sotiris Korossis (5214488), Heiner Niemann (196135), Erdmann Rapp (193330), Andres Hilfiker (60280), Sugat Ratna Tuladhar (21606083), Konrad Fischer (6581888), Falk F. R. Buettner (418608), Axel Haverich (295514), Angelika Schnieke (133290), Charlotte Rossdam (6684647), Samanta Cajic (18625961), Lucrezia Morticelli (7205276), Mikhail Magdei (21606080)   +14 more
core   +5 more sources