Results 1 to 10 of about 1,393,861 (205)

Transcriptome profiling of immune rejection mechanisms in a porcine vascularized composite allotransplantation model [PDF]

Frontiers in Immunology
BackgroundVascularized composite allotransplantation (VCA) offers the potential for a biological, functional reconstruction in individuals with limb loss or facial disfigurement.
Lei Zhang, Lei Zhang, Isabel Arenas Hoyos, Anja Helmer, Yara Banz, Cédric Zubler, Ioana Lese, Ioana Lese, Stefanie Hirsiger, Mihai Constantinescu, Robert Rieben, Mitra Gultom, Radu Olariu, Radu Olariu   +13 more
doaj   +7 more sources

Advances in Innate Immunity to Overcome Immune Rejection during Xenotransplantation [PDF]

Cells, 2022
Transplantation is an effective approach for treating end-stage organ failure. There has been a long-standing interest in xenotransplantation as a means of increasing the number of available organs. In the past decade, there has been tremendous progress in xenotransplantation accelerated by the development of rapid gene-editing tools and ...
Chuan Qin, Shou-Long Deng, Xuguang Du
exaly   +5 more sources

Insight on immune cells in rejection and infection postlung transplant

Immunity, Inflammation and Disease, 2023
Objective The aim of this study is to provide a concise overview of the role of immune cells in rejection and infection after lung transplantation. Methods Based on previous clinical and basic studies, the role of various types of immune cells in the ...
Mingfeng Liao, Chaoxi Wang, Mingxia Zhang, Kun Qiao   +3 more
doaj   +2 more sources

Artificial intelligence optimizes immune rejection prediction and management in heart transplantation: a structured narrative review [PDF]

Frontiers in Cardiovascular Medicine
BackgroundHeart transplantation remains the definitive therapy for end-stage heart failure, yet long-term outcomes are limited by three core clinical bottlenecks in immune rejection management: imprecise preoperative donor-recipient matching ...
Kaixin Chen, Junlin Lai, Yijie Luo, Chenghao Li, Guohua Wang   +4 more
doaj   +2 more sources

Epigenetic regulation in transplant rejection and tolerance: mechanisms and therapeutic prospects [PDF]

Frontiers in Cardiovascular Medicine
Epigenetics modulates gene expression and plays a pivotal role in numerous immune disorders. Over the past two decades, increasing evidence has indicated that epigenetic regulation contributes to transplant rejection and immune tolerance.
Yuhao Li, Yuhao Li, Shuan Ran, Shuan Ran, Yanqiang Zou, Yanqiang Zou, JiKai Cui, JiKai Cui, JiKai Cui   +8 more
doaj   +2 more sources

The multifunctional roles of autophagy in the innate immune response: Implications for regulation of transplantation rejection

Frontiers in Cell and Developmental Biology, 2022
Organ transplantation is the main treatment for end-stage organ failure, which has rescued tens of thousands of lives. Immune rejection is the main factor affecting the survival of transplanted organs.
Kunli Zhang, Qiuyan Huang, Laru Peng, Sen Lin, Jie Liu, Jianfeng Zhang, Jianfeng Zhang, Chunling Li, Shaolun Zhai, Zhihong Xu, Sutian Wang, Sutian Wang   +11 more
doaj   +1 more source

Modeling rejection immunity [PDF]

Theoretical Biology and Medical Modelling, 2012
Transplantation is often the only way to treat a number of diseases leading to organ failure. To overcome rejection towards the transplanted organ (graft), immunosuppression therapies are used, which have considerable side-effects and expose patients to opportunistic infections.
De Gaetano, Aa, Matone, Aa, Agnes, Ab, Palumbo, Pa, Ria, Fc, Magalini, Sb   +11 more
openaire   +4 more sources

An Efficacious Transgenic Strategy for Triple Knockout of Xeno-Reactive Antigen Genes GGTA1, CMAH, and B4GALNT2 from Jeju Native Pigs

Vaccines, 2022
Pigs are promising donors of biological materials for xenotransplantation; however, cell surface carbohydrate antigens, including galactose-alpha-1,3-galactose (α-Gal), N-glycolylneuraminic acid (Neu5Gc), and Sd blood group antigens, play a significant ...
Seungwon Yoon, Seulgi Lee, Chungyu Park, Hyunyong Choi, Minwoo Yoo, Sang Chul Lee, Cheol-Ho Hyun, Nameun Kim, Taeyoung Kang, Eugene Son, Mrinmoy Ghosh, Young-Ok Son, Chang-Gi Hur   +12 more
doaj   +1 more source

Co-expression of HLA-E and HLA-G on genetically modified porcine endothelial cells attenuates human NK cell-mediated degranulation

Frontiers in Immunology, 2023
Natural killer (NK) cells play an important role in immune rejection in solid organ transplantation. To mitigate human NK cell activation in xenotransplantation, introducing inhibitory ligands on xenografts via genetic engineering of pigs may protect the
Arthur A. Cross-Najafi, Kristine Farag, Abdulkadir Isidan, Wei Li, Wenjun Zhang, Zhansong Lin, Julia R. Walsh, Kevin Lopez, Yujin Park, Nancy G. Higgins, David K.C. Cooper, Burcin Ekser, Ping Li   +12 more
doaj   +1 more source

Systematic Review of the Safety of Immune Checkpoint Inhibitors Among Kidney Transplant Patients

Kidney International Reports, 2020
Introduction: Kidney transplant (Ktx) recipients are excluded from clinical trials of immune checkpoint inhibitors. The aim of this systematic review was to assess the safety of immune checkpoint inhibitors among Ktx patients.
Sandhya Manohar, Charat Thongprayoon, Wisit Cheungpasitporn, Svetomir N. Markovic, Sandra M. Herrmann   +4 more
doaj   +1 more source