Overdose intake of Neu5Gc triggers colorectal inflammation and alters liver metabolism
Food and Agricultural Immunology, 2023 A positive correlation between massive red meat consumption with colorectal cancer had been reported. Given the complexity of meat components, we focused on investigating the role of Neu5Gc in human healthy.
Teng Yuan +11 more
doaj +1 more source
Vaccines, 2022 Pigs are promising donors of biological materials for xenotransplantation; however, cell surface carbohydrate antigens, including galactose-alpha-1,3-galactose (α-Gal), N-glycolylneuraminic acid (Neu5Gc), and Sd blood group antigens, play a significant ...
Seungwon Yoon +12 more
doaj +1 more source
Highly efficient multiplex genetic engineering of porcine primary fetal fibroblasts
Surgery Open Science, 2021 Background: Genetically engineered porcine donors are a potential solution for the shortage of human organs for transplantation. Incompatibilities between humans and porcine donors are largely due to carbohydrate xenoantigens on the surface of porcine ...
Benjamin Klapholz, PhD +6 more
doaj +1 more source
Triple gene editing in porcine embryos using electroporation alone or in combination with microinjection [PDF]
Veterinary World, 2022 Background and Aim: We previously developed the gene-editing by electroporation (EP) of Cas9 protein method, in which the CRISPR/Cas9 system was introduced into porcine in vitro fertilized (IVF) zygotes through EP to disrupt a target gene.
Zhao Namula +8 more
doaj +1 more source
Sialic Acids as Receptors for Pathogens
Biomolecules, 2021 Carbohydrates have long been known to mediate intracellular interactions, whether within one organism or between different organisms. Sialic acids (Sias) are carbohydrates that usually occupy the terminal positions in longer carbohydrate chains, which ...
Patrycja Burzyńska +4 more
doaj +1 more source
Phylogenetic Distribution of CMP-Neu5Ac Hydroxylase (CMAH), the Enzyme Synthetizing the Proinflammatory Human Xenoantigen Neu5Gc [PDF]
, 2017 The enzyme CMP-N-acetylneuraminic acid hydroxylase (CMAH) is responsible for the synthesis of N-glycolylneuraminic acid (Neu5Gc), a sialic acid present on the cell surface proteins of most deuterostomes.
Felix Feyertag +14 more
core +1 more source
Silencing Porcine CMAH and GGTA1 Genes Significantly Reduces Xenogeneic Consumption of Human Platelets by Porcine Livers [PDF]
, 2016 Background. A profound thrombocytopenia limits hepatic xenotransplantation in the pig-to-primate model. Porcine livers also have shown the ability to phagocytose human platelets in the absence of immune-mediated injury.
Tector, A. Joseph +11 more
core +1 more source
Cmah deficiency may lead to age-related hearing loss by influencing miRNA-PPAR mediated signaling pathway [PDF]
PeerJ, 2019 Background Previous evidence has indicated CMP-Neu5Ac hydroxylase (Cmah) disruption inducesaging-related hearing loss (AHL). However, its function mechanisms remain unclear.
Juhong Zhang, Na Wang, Anting Xu
doaj +2 more sources
Antitumor effects of the GM3(Neu5Gc) ganglioside-specific humanized antibody 14F7hT against Cmah-transfected cancer cells. [PDF]
, 2019 The GM3(Neu5Gc) ganglioside represents a tumor-specific antigen that is considered a promising target for cancer immunotherapy. We previously demonstrated that the humanized antibody 14F7hT, specific for this ganglioside, exhibited significant antitumor ...
Simon, Hans-Uwe +9 more
core +2 more sources
Frontiers in Immunology, 2022 Chimeric antigen receptor (CAR) T cells have emerged as a powerful immunotherapeutic tool against certain hematological malignancies but a significant proportion of patients either do not respond or they relapse, sometimes as a result of target antigen ...
Elisabetta Cribioli +3 more
doaj +1 more source