Results 41 to 50 of about 2,006 (151)
Human evolutionary loss of epithelial Neu5Gc expression and species-specific susceptibility to cholera. [PDF]
PLoS Pathogens, 2018 While infectious agents have typical host preferences, the noninvasive enteric bacterium Vibrio cholerae is remarkable for its ability to survive in many environments, yet cause diarrheal disease (cholera) only in humans. One key V.
Frederico Alisson-Silva +10 more
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Cells, 2021 Transplantation of xenogenic porcine chondrocytes could represent a future strategy for the treatment of human articular cartilage defects. Major obstacles are humoral and cellular rejection processes triggered by xenogenic epitopes like α-1,3-Gal and ...
Hanna Tritschler +7 more
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, 2016 (A) Genomic structure of cat’s CMAH gene obtained from the comparative analysis of mRNA sequences and whole genome shotgun sequence (Accession No.NC_018727.2, chromosome B). Exon 1a is located upstream of exon 1b.
Shigenori Ikemoto (3226944) +18 more
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, 2023 Supplementary files for article "Genetic knockout of porcine GGTA1 or CMAH/GGTA1 is associated with the emergence of neo-glycans"Background: Pig-derived tissues could overcome the shortage of human donor organs in transplantation.
Dietmar Böthig (21606075) +14 more
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, 2014 WT mice expressed both Cmah and Neu5Gc epitopes. Cmah-dKO mice were completely deficient for both CMAH and Neu5Gc epitopes in the lung, kidney, and heart tissues. Bar: 100 µm. LU; lung, KI; kidney, HE; heart.
Byung-Soo Chang (630761) +2 more
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Construction of CMAH gene-edited vectors.
, 2019 The porcine CMAH gene editing sites were designated on exon 2 (sense strand, red capital letters underlined in red) and intron 2 (antisense strand, red letters underlined in red). The sequences underlined in black are PCR primers (CMAH Ex2 F and CMAH Ex2
Kai-Hsuan Hsiao (6751745) +11 more
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PLoS ONE, 2019 The porcine epidemic diarrhoea virus (PEDV) devastates the health of piglets but may not infect piglets whose CMP-N-glycolylneuraminic acid hydroxylase (CMAH) gene is mutated (knockouts, KO) by using CRISPR/Cas9 gene editing techniques.
Ching-Fu Tu +11 more
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Generation of CMAH gene-edited pigs.
, 2019 A. Four lines of CMAH gene-edited piglets (1 male, L667-02, and 3 females, L667-10, 11, and 12) were obtained. B. CMAH KO piglets were analysed and screened by PCR.
Kai-Hsuan Hsiao (6751745) +11 more
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Sialyltransferase gene expression levels in WT and Cmah-dKO mice.
, 2014 A. Comparison of sialyltransferase gene expression in the liver of WT and Cmah-dKO mice by RT-qPCR. B. RT-qPCR analysis in liver of WT and Cmah-dKO mice. All RT-qPCR were conducted in triplicate and normalized with mouse Gadph gene expression.
Byung-Soo Chang (630761) +2 more
core +1 more source
Data from: Human-like Cmah inactivation in mice increases running endurance and decreases muscle fatigability: implications for human evolution [PDF]
, 2018 Compared to other primates, humans are exceptional long-distance runners, a feature that emerged in genus Homo ~2 million years ago (mya) and is classically attributed to anatomical and physiological adaptations such as an enlarged gluteus maximus and ...
Breen, Ellen C. +13 more
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