Results 61 to 70 of about 2,679 (152)

Genetic Divergence and Antibody Expression Influence the N‐Glycomes of CHO‐K1 and CHO‐S Cells

Biotechnology and Bioengineering, Volume 122, Issue 11, Page 3160-3175, November 2025.
ABSTRACT While Chinese hamster ovary (CHO) cells continue to be the workhorse of recombinant therapeutic protein production, decades of genetic divergence in the industrially relevant CHO‐K1 and CHO‐S cell lines, are likely to have resulted in differing glycosylation capabilities. Glycosylation can influence the efficacy, serum half‐life, and safety of
Roberto Donini, Pat Blundell, Richard J. Pleass, Dongli Lu, Anne Dell, Cleo Kontoravdi, Stuart M. Haslam   +6 more
wiley   +1 more source

Enzymatic Synthesis of Trideuterated Sialosides

Molecules, 2019
Sialic acids are a family of acidic monosaccharides often found on the termini of cell surface proteins or lipid glycoconjugates of higher animals. Herein we describe the enzymatic synthesis of the two isotopically labeled sialic acid derivatives d3-X ...
Zhi-P. Cai, Louis P. Conway, Ying Y. Huang, Wen J. Wang, Pedro Laborda, Ting Wang, Ai M. Lu, Hong L. Yao, Kun Huang, Sabine L. Flitsch, Li Liu, Josef Voglmeir   +11 more
doaj   +1 more source

N-glycolylneuraminic acid and N-acetylneuraminic acid define feline blood group A and B antigens [PDF]

Blood, 1992
Abstract Blood group incompatibility causes transfusion reactions and neonatal isoerythrolysis in cats. We investigated the molecular nature of the blood group antigens from cats that had blood type A, B, and AB erythrocytes. Naturally occurring anti-type B antibodies, Triticum vulgaris lectin, monoclonal antibody (MoAb) 32–27, and MoAb ...
G A, Andrews, P S, Chavey, J E, Smith, L, Rich   +3 more
openaire   +3 more sources

Acupuncture for Major Depressive Disorder: Exploring the Gut Microbiota as a Novel Therapeutic Pathway

Brain and Behavior, Volume 15, Issue 11, November 2025.
Acupuncture at GV20 and ST36 alleviates depression by modulating gut microbiota, increasing beneficial bacteria, and enhancing neuroactive metabolites like Sphinganine 1‐phosphate, thereby restoring neuronal activity and reducing depressive behaviors. ABSTRACT Aims This study investigates the efficacy of acupuncture at Baihui (GV20) and Zusanli (ST36 ...
Cailing Wei, Yijun Li, Jiarong Tian, Pu Lei, Yuanyuan Ding, Wen Lu, Xiaoyan He, Ya'ni Yang, Hao Zhu, Ruina Liu   +9 more
wiley   +1 more source

Potential Effects of Three Forms of Sialic Acid on Intestinal Health in Obese Mice Fed With a High‐Fat Diet

Food Frontiers, Volume 6, Issue 6, Page 3090-3107, November 2025.
A high‐fat diet impairs intestinal health by disrupting the mucus layer, widening epithelial gaps, triggering inflammation, and causing microbial dysbiosis, ultimately leading to obesity and metabolic disorders. Sialic acid interventionsparticularly bound forms (3ʹ‐SL and EBN)outperform free Neu5Ac in restoring microbial balance, alleviating ...
Xinyue Wang, Wei Zhang, Xinyuan Huang, Linlin Zhou, Xinning Zhao, Hanying Zheng, Xudan Shen, Xinyi Wang, Lili Pan, Yahui Li, Hongwei Li   +10 more
wiley   +1 more source

Revolutionizing Heart Valve Therapy: A Translational Framework for Combining Decellularized Scaffolds With Genetic Modification

Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 113, Issue 11, November 2025.
ABSTRACT Valvular heart disease (VHD) represents a significant global health challenge, affecting over 2.5% of the population and disproportionately impacting older adults due to age‐related degenerative processes. Current treatment options—mechanical and bioprosthetic valves—both present substantial limitations that impact patient quality of life and ...
Nikolaos P. Tzavellas, Natalia Atzemoglou, Efstathios L. Pavlidis, Alkinoos Nikolis, Georgios S. Markopoulos, Konstantinos I. Tsamis, Dimitrios Peschos, Yannis V. Simos, Lampros Lakkas   +8 more
wiley   +1 more source

Variability of Sialic Acids in Beef Breeds and Nutritional Implications in Red Meat

Molecules
This study examines the variability of sialic acids, specifically N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc), in beef from seven cattle breeds (Holstein Friesian, Red Pied, Maremmana, Chianina, Charolais, Limousin, and ...
Michela Contò, Maria Miarelli, Sabrina Di Giovanni, Sebastiana Failla   +3 more
doaj   +1 more source

Possible Influences of Endogenous and Exogenous Ligands on the Evolution of Human Siglecs

Frontiers in Immunology, 2018
Sialic acids, a group of acidic sugars abundantly expressed in the tissues of deuterostome animals but rarely found in microbes, serve as a “signature of self” for these animals. Cognate sensors for sialic acids include Siglecs, a family of transmembrane
Takashi Angata
doaj   +1 more source

High-mannose type N-glycans with core fucosylation and complex-type N-glycans with terminal neuraminic acid residues are unique to porcine islets.

PLoS ONE, 2020
ObjectivesIslet transplantation is an emerging treatment option for type 1 diabetes but its application is limited by the shortage of human pancreas donors.
Yoshihide Nanno, Asif Shajahan, Roberto N Sonon, Parastoo Azadi, Bernhard J Hering, Christopher Burlak   +5 more
doaj   +1 more source

Isolation of N-acetylneuraminic Acid and N-glycolylneuraminic Acid from Pleurocybella porrigens

Journal of Health Science, 2009
Pleurocybella porrigens (P. porrigens )i s a traditional food consumed in Japan. Toxicity was first reported in 2004, following which a series of poisonings were reported in 2007. More than 59 people who consumed P. porrigens suffered from similar severe cryptogenic encephalitis, with an overall death rate of approximately 29%. P. porrigens is believed
Takata, Takanobu, Hasegawa, Tatsuya, Tatsuno, Takanori, Date, Junichiro, Ishigaki, Yasuhito, Nakamura, Yuka, Tomosugi, Naohisa, Takano, Fumihide, Ohta, Tomihisa   +8 more
openaire   +2 more sources