Results 81 to 90 of about 15,525,833 (178)

The use of transgenic animals for xenotransplantation: An update

Animal Models and Experimental Medicine, Volume 8, Issue 11, Page 2041-2052, November 2025.
One way to produce genetically modified pigs is to use somatic cell nuclear transfer (SCNT). This procedure involves removing the metaphase plate from a mature oocyte using micromanipulation and then transferring the modified nucleus from the donor somatic cell to the oocyte.
Julia Motławska, Ana Amaral, Marta Cerveira‐Pinto, Paweł Kordowitzki   +3 more
wiley   +1 more source

Isolation of N-acetylneuraminic Acid and N-glycolylneuraminic Acid from Pleurocybella porrigens

Journal of Health Science, 2009
Pleurocybella porrigens (P. porrigens )i s a traditional food consumed in Japan. Toxicity was first reported in 2004, following which a series of poisonings were reported in 2007. More than 59 people who consumed P. porrigens suffered from similar severe cryptogenic encephalitis, with an overall death rate of approximately 29%. P. porrigens is believed
Takata, Takanobu, Hasegawa, Tatsuya, Tatsuno, Takanori, Date, Junichiro, Ishigaki, Yasuhito, Nakamura, Yuka, Tomosugi, Naohisa, Takano, Fumihide, Ohta, Tomihisa   +8 more
openaire   +2 more sources

Synthetic O-Acetyl- N-glycolylneuraminic Acid Oligosaccharides Reveal Host-Associated Binding Patterns of Coronaviral Glycoproteins. [PDF]

, 2022
A panel of O-acetylated N-glycolylneuraminic acid oligosaccharides has been prepared by diversification of common synthetic precursors by regioselective de- O-acetylation by coronaviral hemagglutinin-esterase (HE) combined with C7-to-C9 acetyl ester ...
Li, Zeshi, Lang, Yifei, de Groot, Raoul J, Unione, Luca, Liu, Lin, Boons, Geert-Jan   +5 more
core  

Variability of Sialic Acids in Beef Breeds and Nutritional Implications in Red Meat

Molecules
This study examines the variability of sialic acids, specifically N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc), in beef from seven cattle breeds (Holstein Friesian, Red Pied, Maremmana, Chianina, Charolais, Limousin, and ...
Michela Contò, Maria Miarelli, Sabrina Di Giovanni, Sebastiana Failla   +3 more
doaj   +1 more source

Possible Influences of Endogenous and Exogenous Ligands on the Evolution of Human Siglecs

Frontiers in Immunology, 2018
Sialic acids, a group of acidic sugars abundantly expressed in the tissues of deuterostome animals but rarely found in microbes, serve as a “signature of self” for these animals. Cognate sensors for sialic acids include Siglecs, a family of transmembrane
Takashi Angata
doaj   +1 more source

High-mannose type N-glycans with core fucosylation and complex-type N-glycans with terminal neuraminic acid residues are unique to porcine islets.

PLoS ONE, 2020
ObjectivesIslet transplantation is an emerging treatment option for type 1 diabetes but its application is limited by the shortage of human pancreas donors.
Yoshihide Nanno, Asif Shajahan, Roberto N Sonon, Parastoo Azadi, Bernhard J Hering, Christopher Burlak   +5 more
doaj   +1 more source

Genetic Divergence and Antibody Expression Influence the N‐Glycomes of CHO‐K1 and CHO‐S Cells

Biotechnology and Bioengineering, Volume 122, Issue 11, Page 3160-3175, November 2025.
ABSTRACT While Chinese hamster ovary (CHO) cells continue to be the workhorse of recombinant therapeutic protein production, decades of genetic divergence in the industrially relevant CHO‐K1 and CHO‐S cell lines, are likely to have resulted in differing glycosylation capabilities. Glycosylation can influence the efficacy, serum half‐life, and safety of
Roberto Donini, Pat Blundell, Richard J. Pleass, Dongli Lu, Anne Dell, Cleo Kontoravdi, Stuart M. Haslam   +6 more
wiley   +1 more source

Progress in Studies on Relationship between Red Meat Intake, N-Glycolylneuraminic Acid and Cancer Risk [PDF]

, 2014
世界癌症研究基金会报告指出,过多摄入红肉会增加患癌症的风险,红肉可能是导致某些癌症的原因之一。有研究得出,摄入红肉后身体内产生的一种唾液酸——n-羟乙酰神经氨酸(n-glyCOlylnEurAMInIC ACId,nEu5gC)可能与癌症的发生有关。本文从红肉与癌的关系,引出对nEu5gC的讨论,从它的结构、来源、生理功能到临床应用价值,最后是与癌症可能的机制讨论,并重申它的研究价值。According to the World Cancer Research Fund, excessive ...
李红卫, 范杏丹
core  

SEMISYNTHETIC PREPARATION OF N-GLYCOLYLNEURAMINIC ACID CONTAINING GM1 GANGLIOSIDE - CHEMICAL CHARACTERIZATION, PHYSICOCHEMICAL PROPERTIES AND SOME BIOCHEMICAL FEATURES

, 1988
N-Glycolylneuraminic acid containing GM1, GM1(NeuGc), was prepared by semisynthetic procedure. The procedure makes use of GM1 ganglioside deacetylated at the level of sialic acid residue (deAc-GM1) and of 1,3-dioxalan-2,4-dione. DeAc-GM1 is prepared from
G. TETTAMANTI, L. CANTU, M. PITTO, S. SONNINO, V. CHIGORNO, G. KIRSCHNER, D. ACQUOTTI, G. FRONZA   +7 more
core   +1 more source

The essential malaria protein PfCyRPA targets glycans to invade erythrocytes

Cell Reports
Summary: Plasmodium falciparum is a human-adapted apicomplexan parasite that causes the most dangerous form of malaria. P. falciparum cysteine-rich protective antigen (PfCyRPA) is an invasion complex protein essential for erythrocyte invasion.
Christopher J. Day, Paola Favuzza, Sabrina Bielfeld, Thomas Haselhorst, Leonie Seefeldt, Julia Hauser, Lucy K. Shewell, Christian Flueck, Jessica Poole, Freda E.-C. Jen, Anja Schäfer, Jean-Pierre Dangy, Tim-W. Gilberger, Camila Tenorio França, Manoj T. Duraisingh, Marco Tamborrini, Nicolas M.B. Brancucci, Christof Grüring, Michael Filarsky, Michael P. Jennings, Gerd Pluschke   +20 more
doaj   +1 more source