Results 101 to 110 of about 15,525,833 (178)

The Sodium Sialic Acid Symporter From Staphylococcus aureus Has Altered Substrate Specificity

Frontiers in Chemistry, 2018
Mammalian cell surfaces are decorated with complex glycoconjugates that terminate with negatively charged sialic acids. Commensal and pathogenic bacteria can use host-derived sialic acids for a competitive advantage, but require a functional sialic acid ...
Rachel A. North, Rachel A. North, Rachel A. North, Weixiao Y. Wahlgren, Weixiao Y. Wahlgren, Daniela M. Remus, Daniela M. Remus, Mariafrancesca Scalise, Sarah A. Kessans, Sarah A. Kessans, Elin Dunevall, Elin Claesson, Tatiana P. Soares da Costa, Matthew A. Perugini, S. Ramaswamy, Jane R. Allison, Jane R. Allison, Jane R. Allison, Cesare Indiveri, Rosmarie Friemann, Rosmarie Friemann, Renwick C. J. Dobson, Renwick C. J. Dobson   +22 more
doaj   +1 more source

Loss of a newly discovered microRNA in Chinese hamster ovary cells leads to upregulation of N-glycolylneuraminic acid sialylation on monoclonal antibodies. [PDF]

Biotechnol Bioeng, 2022
Fischer S, Mathias S, Stadermann A, Yang S, Schmieder V, Zeh N, Schmidt N, Richter P, Wright S, Zimmermann E, Ley Y, van der Meer J, Hartsch T, Bernloehr C, Otte K, Bradl H, Gamer M, Schulz P.   +17 more
europepmc   +1 more source

Exploring the Arctic Charr Intestinal Glycome: Evidence of Increased N‑Glycolylneuraminic Acid Levels and Changed Host–Pathogen Interactions in Response to Inflammation

, 2019
Disease outbreaks are a limiting factor for the sustainable development of the aquaculture industry. The intestinal tract is covered by a mucus layer mainly comprised by highly glycosylated proteins called mucins.
János T. Padra (6482366), Aleksander Vidakovic (6482372), Kristina Sundell (1555405), Vignesh Venkatakrishnan (802995), Hanna Carlberg (4096216), Chunsheng Jin (349807), Torbjörn Lundh (6482375), Sara K. Lindén (1555399), Niclas G. Karlsson (754807), Markus Langeland (6482369), Henrik Sundh (561173)   +10 more
core   +1 more source

Inactivation of the CMAH gene and deficiency of Neu5Gc play a role in human brain evolution

Inflammation and Regeneration
During human evolution, some genes were lost or silenced from the genome of hominins. These missing genes might be the key to the evolution of humans’ unique cognitive skills. An inactivation mutation in CMP-N-acetylneuraminic acid hydroxylase (CMAH) was
Yuxin Liu, Jinhong Li, Qicai Liu
doaj   +1 more source

Serum Antibodies to N-Glycolylneuraminic Acid Are Elevated in Duchenne Muscular Dystrophy and Correlate with Increased Disease Pathology in Cmah^-/-mdx Mice. [PDF]

Am J Pathol, 2021
Martin PT, Kawanishi K, Ashbrook A, Golden B, Samraj A, Crowe KE, Zygmunt DA, Okerblom J, Yu H, Maki A, Diaz S, Chen X, Janssen PML, Varki A.   +13 more
europepmc   +1 more source

Loss of N-Glycolylneuraminic Acid in Human Evolution [PDF]

Journal of Biological Chemistry, 2000
Els C.M. Brinkman-Van der Linden, Eric R. Sjoberg, Lekh Raj Juneja, Paul R. Crocker, Nissi Varki, Ajit Varki   +5 more
openaire   +1 more source

Editorial: Human Antibodies Against the Dietary Non-human Neu5Gc-Carrying Glycans in Normal and Pathologic States

Frontiers in Immunology, 2020
Jean-Paul Soulillou, Jean-Paul Soulillou, Vered Padler-Karavani   +2 more
doaj   +1 more source

Absorption and Transport Mechanism of Red Meat-Derived N-glycolylneuraminic Acid and Its Damage to Intestinal Barrier Function through the NF-κB Signaling Pathway. [PDF]

Toxins (Basel), 2023
He E, Quan W, Luo J, Liu C, Zheng W, Shen Q.   +5 more
europepmc   +1 more source

Effect of Factor H on Complement Alternative Pathway Activation in Human Serum Remains on Porcine Cells Lacking N-Glycolylneuraminic Acid. [PDF]

Front Immunol, 2022
Lee H, Park EM, Ko N, Choi K, Oh KB, Kang HJ.   +5 more
europepmc   +1 more source

Chemoenzymatic synthesis and characterization of N-glycolylneuraminic acid-carrying sialoglycopolypeptides as effective inhibitors against equine influenza virus hemagglutination

, 2017
A series of novel sialoglycopolypeptides carrying N-glycolylneuraminic acid (Neu5Gc)-containing trisaccharides having α(2 → 3)- and α(2 → 6)-linkages in the side chains of γ-polyglutamic acid (γ-PGA) were designed as competitive inhibitors against equine
Ami Koizumi, Kiyoshi Ikeda, Rena Aita, Enoch Y Park, Kazuya I P J Hidari, Makoto Ogata, Mao Sakamoto, Tadamune Otsubo, Tatsuya Kato, Takashi Yamanaka   +9 more
core   +1 more source