Results 91 to 100 of about 15,525,833 (178)

Understanding the Effects of Lactose Hydrolysis Modeling on the Main Oligosaccharides in Goat Milk Whey Permeate

Molecules, 2019
Enzymatic hydrolysis of lactose is a crucial step to improve the efficiency and selectivity of membrane-based separations toward the recovery of milk oligosaccharides free from simple sugars.
Caroline Thum, Valerie Weinborn, Daniela Barile, Warren C McNabb, Nicole C Roy, Juliana Maria Leite Nobrega de Moura Bell   +5 more
doaj   +1 more source

Selective Oxidation of N‑Glycolylneuraminic Acid Using an Engineered Galactose Oxidase Variant

, 2019
N-Glycolylneuraminic acid (Neu5Gc) is a common cell-surface ligand in animals which is not biosynthesized in humans, but it can be acquired in human tissue from dietary sources such as red meat.
Nico Kress (7146680), Jolanda M. van Munster (687161), William R. Birmingham, Juana E. R. Martinez (7146683), Nicholas J. Turner, Juana E. R. Martinez, Peter Both, Nico Kress, Gregory S. Bulmer, Ashley P. Mattey (7146677), William R. Birmingham (2107420), Fabio Parmeggiani (691842), Gregory S. Bulmer (6659336), Josef Voglmeir (1466209), Fabio Parmeggiani, Sabine L. Flitsch (212529), Josef Voglmeir, Kun Huang (136241), Sabine L. Flitsch, Nicholas J. Turner (225510), Kun Huang, Peter Both (2103751), Ashley P. Mattey, Jolanda M. van Munster   +23 more
core   +1 more source

Preclinical evaluation of racotumomab, an anti-idiotype monoclonal antibody to N-glycolyl-containing gangliosides, with or without chemotherapy in a mouse model of non-small cell lung cancer

Frontiers in Oncology, 2012
N-glycolylneuraminic acid (NeuGc) is a sialic acid molecule usually found in mammalian cells as terminal constituents of different membrane glycoconjugates such as gangliosides. The NeuGcGM3 ganglioside has been described as a tumor antigen for non-small
Valeria I Segatori, Ana María Vazquez, Daniel E. Gomez, Mariano R. Gabri, Daniel F Alonso   +4 more
doaj   +1 more source

Exploring the Arctic Charr Intestinal Glycome: Evidence of Increased N-Glycolylneuraminic Acid Levels and Changed Host-Pathogen Interactions in Response to Inflammation

, 2019
Disease outbreaks are a limiting factor for the sustainable development of the aquaculture industry. The intestinal tract is covered by a mucus layer mainly comprised by highly glycosylated proteins called mucins.
Carlberg, H., Venkatakrishnan, Vignesh,, Padra, János T,, Sundh, Henrik,, Lindén, Sara K.,, Vidakovic, A., Karlsson, Niclas G.,, Jin, Chunsheng,, Sundell, Kristina,, Langeland, M., Lundh, T.   +10 more
core   +2 more sources

An atlas of human siglecs integrates expression, affinity, and cis/trans sialoglycan recognition profiles

Nature Communications
All living cells have a sugar-coat that facilitates communication. Sialic acids cap mammalian glycans and are recognized by immune cells through sialic acid-binding immunoglobulin-like lectins (Siglecs) that regulate signaling by their cytoplasmic motifs.
Shani Leviatan Ben-Arye, Edward N. Schmidt, Zeinab Jame-Chenarboo, Claire Guetta-Oz, Fahima Mozaneh, Jaesoo Jung, Kelli A. McCord, Ronit Rosenfeld, Kan Zhong, Hongzhi Cao, Hai Yu, Xi Chen, Lori J. West, Matthew S. Macauley, Vered Padler-Karavani   +14 more
doaj   +1 more source

Theoretical Studies on the Electronic Structure Parameters and Reactive Activity of Neu5Gc and Neu5Ac under Food Processing Solvent Environment

Molecules, 2019
The animal product hazard factor N-glycolylneuraminic (Neu5Gc) and brain nutrient substance N-acetylneuraminic acid (Neu5Ac) were studied at the M062X/6-311 + G(d,p) geometry optimization level.
Rui Chang, Bowen Yang, Qiu-Jin Zhu
doaj   +1 more source

Replication of H9 influenza viruses in the human ex vivo respiratory tract, and the influence of neuraminidase on virus release

Scientific Reports, 2017
H9N2 viruses are the most widespread influenza viruses in poultry in Asia. We evaluated the infection and tropism of human and avian H9 influenza virus in the human respiratory tract using ex vivo respiratory organ culture.
Renee W. Y. Chan, Louisa L. Y. Chan, Chris K. P. Mok, Jimmy Lai, Kin P. Tao, Adebimpe Obadan, Michael C. W. Chan, Daniel R. Perez, J. S. Malik Peiris, John M. Nicholls   +9 more
doaj   +1 more source

Knock-out of N-glycolylneuraminic acid attenuates antibody-mediated rejection in xenogenically perfused porcine lungs. [PDF]

Xenotransplantation, 2022
Chaban R, Habibabady Z, Hassanein W, Connolly MR, Burdorf L, Redding E, Laird C, Ranek J, Braileanu G, Sendil S, Cheng X, Sun W, O'Neill NA, Kuravi K, Hurh S, Ayares DL, Azimzadeh AM, Pierson RN.   +17 more
europepmc   +1 more source

Double knockout pigs deficient in N-glycolylneuraminic acid and galactose α-1,3-galactose reduce the humoral barrier to xenotransplantation

, 2013
Clinical xenotransplantation is not possible because humans possess antibodies that recognize antigens on the surface of pig cells. Galα-1,3-Gal (Gal) and N-glycolylneuraminic acid (Neu5Gc) are two known xenoantigens.
Paris, Leela L, Chihara, Ray K, Tector, A Joseph, Sidner, Richard A, Reyes, Luz M, Ivary, Bess, Burlak, Christopher, Downey, Susan M, Li, Ping, Yin, Fuqin, Lutz, Andrew J, Blankenship, Ross L, Wang, Zheng-Yu, Estrada, Jose L   +13 more
core   +1 more source

Novel mechanism for the generation of human xeno-autoantibodies against the nonhuman sialic acid N-glycolylneuraminic acid [PDF]

, 2010
The nonhuman sialic acid N-glycolylneuraminic acid (Neu5Gc) is metabolically incorporated into human tissues from certain mammalian-derived foods, and this occurs in the face of an anti-Neu5Gc “xeno-autoantibody” response.
Shengshu Huang, Chen, Xi, Rachel E. Taylor, Sorensen, Ricardo U, Gregg, Christopher J, Ricardo U. Sorensen, Vered Padler-Karavani, Hai Yu, Xi Chen, Varki, Ajit, Taylor, Rachel E, Yu, Hai, Darius Ghaderi, Victor Nizet, Ghaderi, Darius, Jaime Inostroza, Inostroza, Jaime, Ajit Varki, Huang, Shengshu, Christopher J. Gregg, Nizet, Victor, Padler-Karavani, Vered   +21 more
core   +1 more source