Results 41 to 50 of about 2,679 (152)

Current Status of Kidney Xenotransplantation in Basic Research

Organ Medicine, Volume 3, Issue 2, Page 87-101, June 2026.
Kidney xenotransplantation is a potential solution to the organ shortage for end‐stage kidney disease. This review systematically elaborates on the application advances of donor pig gene editing technologies, the molecular mechanisms and regulatory strategies of xenogeneic immune rejection, and the optimization approaches of immune compatibility ...
Yu Luo, Bingzhuo Liu, Weijie Lai
wiley   +1 more source

A Comprehensive Review of Our Current Understanding of Red Blood Cell (RBC) Glycoproteins

Membranes, 2017
Human red blood cells (RBC), which are the cells most commonly used in the study of biological membranes, have some glycoproteins in their cell membrane. These membrane proteins are band 3 and glycophorins A–D, and some substoichiometric glycoproteins (e.
Takahiko Aoki
doaj   +1 more source

Red Meat Derived Glycan, N-acetylneuraminic Acid (Neu5Ac) Is a Major Sialic Acid in Different Skeletal Muscles and Organs of Nine Animal Species—A Guideline for Human Consumers

Foods, 2023
Sialic acids (Sias) are acidic monosaccharides and red meat is a notable dietary source of Sia for humans. Among the Sias, N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-2-nonulosonic acid (KDN) play multiple roles in immunity ...
Marefa Jahan, Peter C. Thomson, Peter C. Wynn, Bing Wang   +3 more
doaj   +1 more source

Mucin Type Drives Composition and Mucin Glycan Degradation of an In Vitro Synthetic Microbial Community

Environmental Microbiology, Volume 28, Issue 5, May 2026.
The human gut outer mucus layer hosts specific microbes. Using a synthetic mucin glycan‐degrading microbial community to mimic this mucosal microbiome, we show that mucin type affects microbial community composition, glycan degradation and metabolite production.
Maryse D. Berkhout, Carol de Ram, Merlijn P. van Gaal, Henk Schols, Clara Belzer, Caroline M. Plugge   +5 more
wiley   +1 more source

Structure of a Sialo-Oligosaccharide from Glycophorin in Carp Red Blood Cell Membranes

Membranes, 2014
We isolated a high-purity carp glycophorin from carp erythrocyte membranes and prepared the oligosaccharide fraction from glycophorin by β-elimination [1].
Takahiko Aoki, Kenji Chimura, Hikaru Sugiura, Yasuko Mizuno   +3 more
doaj   +1 more source

N-glycolyl chondroitin synthesis using metabolically engineered E. coli

AMB Express, 2020
N-glycolyl chondroitin (Gc-CN) is a metabolite of N -glycolylneuraminic acid (Neu5Gc), a sialic acid that is commonly found in mammals, but not humans. Humans can incorporate exogenous Neu5Gc into their tissues from eating red meat.
Adeola E. Awofiranye, Sultan N. Baytas, Ke Xia, Abinaya Badri, Wenqin He, Ajit Varki, Mattheos Koffas, Robert J. Linhardt   +7 more
doaj   +1 more source

An In Silico Functional Analysis of Non-Synonymous Single-Nucleotide Polymorphisms of Bovine CMAH Gene and Potential Implication in Pathogenesis

Pathogens, 2023
The sugar molecule N-glycolylneuraminic acid (Neu5Gc) is one of the most common sialic acids discovered in mammals. Cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) catalyses the conversion of N-acetylneuraminic acid (Neu5Ac) to Neu5Gc ...
Oluwamayowa Joshua Ogun, Opeyemi S. Soremekun, Georg Thaller, Doreen Becker   +3 more
doaj   +1 more source

Isolation and Characterization of Glycophorin from Carp Red Blood Cell Membranes

Membranes, 2014
We isolated a high-purity carp glycophorin from carp erythrocyte membranes following extraction using the lithium diiodosalicylate (LIS)-phenol method and streptomycin treatment.
Takahiko Aoki, Kenji Chimura, Nobuhiro Nakao, Yasuko Mizuno   +3 more
doaj   +1 more source

Perinatal Gut Dysbiosis Reduces Milk Oligosaccharides via LPS‐Mediated Gut–Mammary Signaling in Mice

Food Frontiers, Volume 7, Issue 2, March 2026.
Maternal gut dysbiosis elevates Gram‐negative bacterial lipopolysaccharide (LPS), which enters circulation and accumulates in mammary tissue. This compromises the blood–milk barrier and suppresses key enzymatic genes, ultimately reducing milk oligosaccharide synthesis and potentially affecting neonatal gut microbiota through breastfeeding.
Man‐Lin Zhou, Ye Wang, Yan‐Ling Kang, Bushra Walayat, Bin‐Qi Rui, Qi‐Di Xue, Xi He, Jing‐Yu Yan, Yin‐Hui Liu, Ming Li   +9 more
wiley   +1 more source

Isolation and characterization of the trisialogangliosides from bovine adrenal medulla

Journal of Lipid Research, 1983
Trisialogangliosides were isolated from bovine adrenal medulla by DEAE-Sephadex A-25 and Iatrobeads column chromatography. Their structures were elucidated by sugar analysis, neuraminidase digestion, and permethylation studies. The complete structures of
T Ariga, M Sekine, R K Yu, T Miyatake
doaj   +1 more source