Results 41 to 50 of about 15,525,833 (178)

Gas–liquid chromatographic assay of lipid-bound sialic acids: measurement of gangliosides in brain of several species

Journal of Lipid Research, 1970
A method is described for analysis of gangliosides by GLC assay of the sialic acid component. Mild acid treatment in methanol converted the latter to methyl ketoside methyl ester, which was then chromatographed as the TMS derivative.
ROBERT K. YU, ROBERT W. LEDEEN
doaj   +1 more source

Molecular characterization of cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) associated with the erythrocyte antigens in dogs

Canine Genetics and Epidemiology, 2019
Background N-glycolylneuraminic acid (Neu5Gc) is synthesized from its precursor N-acetylneuraminic acid (Neu5Ac) by cytidine-5′-monophospho-N acetylneuraminic acid hydroxylase (CMAH), which is encoded by the CMAH gene.
Yumiko Uno, Shota Kawakami, Kazuhiko Ochiai, Toshinori Omi   +3 more
doaj   +1 more source

An Overview of the Importance and Value of Porcine Species in Sialic Acid Research

Biology, 2022
Humans frequently interact with pigs, whose meat is also one of the primary sources of animal protein. They are one of the main species at the center of sialic acid (Sia) research.
Oluwamayowa Joshua Ogun, Georg Thaller, Doreen Becker   +2 more
doaj   +1 more source

Substitution of amino acid residue in influenza A virus hemagglutinin affects recognition of sialyl-oligosaccharides containing N-glycolylneuraminic acid [PDF]

, 1999
Sialic acids are essential components of cell surface receptors used by influenza viruses. To determine the molecular mechanisms of viral recognition of two major species of sialic acids, N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid ...
Ohuchi, Masanobu, Suzuki, Yasuo, Daisei Miyamoto, Yoshihiro Kawaoka, Jwa Hidari, Kazuya I.-P., Kiso, Makoto, Kyoko Fukunaga, Yasuo Suzuki, Murakami, Kohji, Akira Ishihama, Sugiyama, Yoshikuni, Toshihiro Ito, Kohji Murakami, Tetsuya Toyoda, Fukunaga, Kyoko, Masanobu Ohuchi, Hiroshi Kida, Miyamoto, Daisei, Toyoda, Tetsuya, Kazuya I.-P. Jwa Hidari, Suzuki, Takashi, Takashi Suzuki, Ito, Toshihiro, Ishihama, Akira, Kawaoka, Yoshihiro, Horiike, Goh, Yoshikuni Sugiyama, Makoto Kiso, Kida, Hiroshi, Hiroyuki Masuda, Masuda, Hiroyuki, Goh Horiike   +31 more
core   +1 more source

Regulation of N-glycolylneuraminic acid biosynthesis in developing pig small intestine [PDF]

Biochemical Journal, 2003
N-Glycolylneuraminic acid (Neu5Gc), an abundant sialic acid in animal glycoconjugates, is formed by the enzyme CMP-N-acetylneuraminic acid (CMP-Neu5Ac) hydroxylase. The amount of Neu5Gc relative to other sialic acids is highly dependent on the species, tissue and developmental stage.
Yanina N, Malykh, Timothy P, King, Elizabeth, Logan, Denise, Kelly, Roland, Schauer, Lee, Shaw   +5 more
openaire   +2 more sources

Proinflammatory Mechanism of N-Glycolylneuraminic Acid in Mice through Regulating the Gut Microbiota [PDF]

Shipin Kexue
In this study, the effect of 18 weeks of dietary supplementation of porcine submaxillary gland mucin (PSM) as an abundant source of N-hydroxyacetylneuraminic acid (Neu5Gc) on the expression of proteins involved in the nuclear factor kappa-B (NF-κB ...
HE Leli, LIU Chuxin, XIAO Yi, SHEN Qingwu, WU Yanyang
doaj   +1 more source

N-glycolylneuraminic acid binding of avian H7 influenza A viruses [PDF]

, 2020
Abstract Influenza A viruses initiate infection by binding to glycans with terminal sialic acids present on the cell surface. Hosts of influenza A viruses variably express two major forms of sialic acid, N-acetylneuraminic acid (NeuAc) and N-glycolylneuraminic acid (NeuGc).
Cindy M. Spruit, Xueyong Zhu, Frederik Broszeit, Alvin X. Han, Roosmarijn van der Woude, Kim M. Bouwman, Michel M. T. Luu, Colin A. Russell, Ian A. Wilson, Geert-Jan Boons, Robert P. de Vries   +10 more
openaire   +2 more sources

Molecular Structural Analysis of Porcine CMAH–Native Ligand Complex and High Throughput Virtual Screening to Identify Novel Inhibitors

Pathogens, 2023
Porcine meat is the most consumed red meat worldwide. Pigs are also vital tools in biological and medical research. However, xenoreactivity between porcine’s N-glycolylneuraminic acid (Neu5Gc) and human anti-Neu5Gc antibodies poses a significant ...
Oluwamayowa Joshua Ogun, Georg Thaller, Doreen Becker   +2 more
doaj   +1 more source

Specificity and utility of SubB2M, a new N-glycolylneuraminic acid lectin

Biochemical and Biophysical Research Communications, 2018
The B subunit of the subtilase cytotoxin (SubB) recognises N-glycolylneuraminic acid (Neu5Gc) containing glycans, the most prominent form of aberrant glycosylation in human cancers. We have previously engineered SubB by construction of a SubBΔS106/ΔT107 mutant (SubB2M) for greater specificity and enhanced recognition of Neu5Gc containing glycans.
Jing Wang, Lucy K. Shewell, Adrienne W. Paton, James C. Paton, Christopher J. Day, Michael P. Jennings   +5 more
openaire   +3 more sources

Analysis of Carbohydrates and Glycoconjugates by Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2023–2024

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley   +1 more source