A comparative study of N-glycolylneuraminic acid (Neu5Gc) and cytotoxic T cell (CT) carbohydrate expression in normal and dystrophin-deficient dog and human skeletal muscle. [PDF]
PLoS ONE, 2014 The expression of N-glycolylneuraminic acid (Neu5Gc) and the cytotoxic T cell (CT) carbohydrate can impact the severity of muscular dystrophy arising from the loss of dystrophin in mdx mice.
Paul T Martin +8 more
doaj +4 more sources
Generation of Cloned Sheep Lacking Galactose-α1,3-Galactose and N-Glycolylneuraminic Acid Antigens. [PDF]
XenotransplantationABSTRACT Livestock have long been regarded as a potential source of donor organs to alleviate the global organ shortage for transplantation. Sheep have a similar anatomy to humans, providing the standard model for demonstrating biocompatibility and performance of biological heart valves to obtain regulatory approval for their use in transplantation ...
Appleby SJ +9 more
europepmc +2 more sources
N-Glycolylneuraminic Acid (Neu5Gc) Null Large Animals by Targeting the CMP-Neu5Gc Hydroxylase (CMAH) [PDF]
Frontiers in Immunology, 2019 The two major sialic acids described in mammalian cells are the N-glycolylneuraminic acid (Neu5Gc) and the N-acetylneuraminic acid (Neu5Ac). Neu5Gc synthesis starts from the N-acetylneuraminic acid (Neu5Ac) precursor modified by an hydroxylic group ...
Andrea Perota +2 more
doaj +2 more sources
Chemo-enzymatic synthesis of the carbohydrate antigen N-glycolylneuraminic acid from glucose [PDF]
Carbohydrate Research, 2010 N-Glycolylneuraminic acid (Neu5Gc) is a non-human sialic acid, which may play a significant role in human pathologies, such as cancer and vascular disease. Further studies into the role of Neu5Gc in human disease are hindered by limited sources of this carbohydrate. Using a chemo-enzymatic approach, Neu5Gc was accessed in six steps from glucose.
Ajit Varki, Oliver M T Pearce
exaly +5 more sources
Monitoring of the sialylation and polysialylation status of sheep milk during early lactation [PDF]
JDS CommunicationsThe beneficial properties of sialylated biomolecules in milk are important for the optimal development of offspring. However, when assessing risk factors in food, the bioactivity of one sialic acid, N -glycolylneuraminic acid (Neu5Gc), is taken into ...
Lisa Isernhagen +4 more
doaj +2 more sources
Sensitive and specific detection of the non-human sialic Acid N-glycolylneuraminic acid in human tissues and biotherapeutic products. [PDF]
PLoS ONE, 2009 BackgroundHumans are genetically defective in synthesizing the common mammalian sialic acid N-glycolylneuraminic acid (Neu5Gc), but can metabolically incorporate it from dietary sources (particularly red meat and milk) into glycoproteins and glycolipids ...
Sandra L Diaz +8 more
doaj +2 more sources
N-Glycolylneuraminic Acid Binding of Avian and Equine H7 Influenza A Viruses. [PDF]
J Virol, 2022 Influenza A viruses (IAV) initiate infection by binding to glycans with terminal sialic acids on the cell surface. Hosts of IAV variably express two major forms of sialic acid, N-acetylneuraminic acid (NeuAc) and N-glycolylneuraminic acid (NeuGc).
Spruit CM +14 more
europepmc +4 more sources
Structural basis of rotavirus strain preference toward N-acetyl- or N-glycolylneuraminic acid-containing receptors. [PDF]
J Virol, 2012 Fulltext embargoed for: 6 months post date of publicationThe rotavirus spike protein domain VP8* is essential for recognition of cell surface carbohydrate receptors, notably those incorporating N-acylneuraminic acids (members of the sialic acid family ...
Yu X +5 more
europepmc +3 more sources
Why Is N-Glycolylneuraminic Acid Rare in the Vertebrate Brain? [PDF]
Top Curr Chem, 2015 The sialic acids N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc) differ by a single oxygen atom and are widely found at the terminal position of glycans on vertebrate cell surfaces. In animals capable of synthesizing Neu5Gc, most tissues and cell types express both sialic acids, in proportions that vary between species. However,
Davies LR, Varki A.
europepmc +4 more sources
Implications of the presence of N-glycolylneuraminic acid in recombinant therapeutic glycoproteins. [PDF]
Nat Biotechnol, 2010 Recombinant glycoprotein therapeutics produced in nonhuman mammalian cell lines and/or with animal serum are often modified with the nonhuman sialic acid N-glycolylneuraminic acid (Neu5Gc; refs. 1,2). This documented contamination has generally been ignored in drug development because healthy individuals were not thought to react to Neu5Gc (ref.
Ghaderi D +4 more
europepmc +4 more sources