N-acetylneuraminic acid: A scrutinizing tool in oral squamous cell carcinoma diagnosis [PDF]
Dental Research Journal, 2017 Background: Oral cancer has one of the highest mortality rate among other malignancies. An attempt has been made to assess the genetic expression of a cell surface glycoprotein component - sialic acid released by the malignant cells which will reflect on
Suganya Rajaram +4 more
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The fate of orally administered sialic acid: First insights from patients with N-acetylneuraminic acid synthase deficiency and control subjects [PDF]
Molecular Genetics and Metabolism Reports, 2021 Background: In NANS deficiency, biallelic mutations in the N-acetylneuraminic acid synthase (NANS) gene impair the endogenous synthesis of sialic acid (N-acetylneuraminic acid) leading to accumulation of the precursor, N-acetyl mannosamine (ManNAc), and ...
Christel Tran +13 more
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Serum N-Acetylneuraminic Acid Is Associated with Atrial Fibrillation and Left Atrial Enlargement [PDF]
Cardiology Research and Practice, 2020 Purpose. Recent studies have indicated that N-acetylneuraminic acid (Neu5Ac) plays a key role in severe coronary artery diseases, involving RhoA signaling pathway activation, which is critically involved in cardiac fibrosis.
Wei Hu +11 more
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Hydroxylation of N-acetylneuraminic Acid Influences the in vivo Tropism of N-linked Sialic Acid-Binding Adeno-Associated Viruses AAV1, AAV5, and AAV6 [PDF]
Frontiers in Medicine, 2021 Adeno-associated virus (AAV) vectors are promising candidates for gene therapy. However, a number of recent preclinical large animal studies failed to translate into the clinic. This illustrates the formidable challenge of choosing the animal models that
Estrella Lopez-Gordo +6 more
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A Novel Variant in CMAH Is Associated with Blood Type AB in Ragdoll Cats. [PDF]
PLoS ONE, 2016 The enzyme cytidine monophospho-N-acetylneuraminic acid hydroxylase is associated with the production of sialic acids on cat red blood cells. The cat has one major blood group with three serotypes; the most common blood type A being dominant to type B. A
Barbara Gandolfi +9 more
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Analysis of the interaction between N-acetylneuraminic acid and disaccharides on silica surface
Хімія, фізика та технологія поверхні, 2020 Nanocomposites based on biomolecules and highly dispersed silica are quite promising for use in many fields of biotechnology. There are many methods of obtaining such materials, in particular, adsorption from liquid or gas phases.
L. M. Ushakova +4 more
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Food Bioengineering, 2022 N‐acetylneuraminic acid (NeuAc), which has been widely used as a nutraceutical and pharmaceutical intermediate, plays an important role in improving brain development and cognition while enhancing immunity. Bacillus subtilis, generally regarded as a food‐
Haoyu Guo +6 more
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Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression
Hepatology, EarlyView., 2022 Improved mitochondrial activity, due to the lack of methylation‐controlled J protein (MCJ), creates a specific microbiota signature that when transferred through cecal microbiota transplantation delays NASH progression by restoring the gut‐liver axis and enhancing hepatic fatty acid oxidation.
María Juárez‐Fernández +18 more
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Comparison of sialic acid content in bovine and buffalo milk and meat
Revista Científica, 2023 Animal-origin food, such as meat and milk, are important sources of sialic acids (SIAs) with relevant implications for human health. Two significant SIAs in mammals are N-acetyl-neuraminic acid (Neu5Ac) and N- glycolylneuraminic acid (Neu-5Gc).
Michela Contò +2 more
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Stem Cell Research, 2020 N-acetylneuraminic acid synthase (NANS), the gene encoding the synthase for N-acetylneuraminic acid (NeuNAc; sialic acid), is closely associated with infantile-onset severe developmental delay and skeletal dysplasia.
Qian Bu +10 more
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