Results 21 to 30 of about 1,001,057 (271)

Hydroxylation of N-acetylneuraminic Acid Influences the in vivo Tropism of N-linked Sialic Acid-Binding Adeno-Associated Viruses AAV1, AAV5, and AAV6 [PDF]

Frontiers in Medicine, 2021
Adeno-associated virus (AAV) vectors are promising candidates for gene therapy. However, a number of recent preclinical large animal studies failed to translate into the clinic. This illustrates the formidable challenge of choosing the animal models that
Estrella Lopez-Gordo, Alejandro Orlowski, Arthur Wang, Alan Weinberg, Susmita Sahoo, Thomas Weber, Thomas Weber   +6 more
doaj   +2 more sources

Preferential Accumulation of 14C-N-Glycolylneuraminic Acid over 14C-N-Acetylneuraminic Acid in the Rat Brain after Tail Vein Injection. [PDF]

PLoS ONE, 2015
The two main molecular species of sialic acid existing in nature are N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc). Neu5Ac is abundant in mammalian brains and plays crucial roles in many neural functions.
Risa Taguchi, Akira Minami, Yukino Matsuda, Tadanobu Takahashi, Tadamune Otsubo, Kiyoshi Ikeda, Takashi Suzuki   +6 more
doaj   +3 more sources

Synthesis of 4-O-Alkylated N-Acetylneuraminic Acid Derivatives. [PDF]

J Org Chem, 2021
Johansson E, Caraballo R, Elofsson M.
europepmc   +3 more sources

Detection of Neuraminidase Activity in Pseudomonas aeruginosa PAO1 [PDF]

Iranian Journal of Basic Medical Sciences, 2010
Objective(s)Some properties of neuraminidase produced by Pseudomonas aeruginosa PAO1 growth in a defined medium (BHI) were examined and evaluated for its features.Materials and MethodsThe obtained supernatant enzyme of P.
Ciamak Ghazaei, Malahat Ahmadi, Nima Hosseini Jazani   +2 more
core   +2 more sources

Syntheses of Legionaminic Acid, Pseudaminic Acid, Acetaminic Acid, 8-epi-Acetaminic Acid, and 8-epi-Legionaminic Acid Glycosyl Donors from N-Acetylneuraminic Acid by Side Chain Exchange. [PDF]

Org Lett, 2022
Siyabalapitiya Arachchige S, Crich D.
europepmc   +3 more sources

Effects of N-Acetylneuraminic Acid on Intestinal Microbial Composition and Metabolic Activity in a Piglet Model. [PDF]

Vet Sci
Zhang J, Ye R, Li X, Liu X, Lian K, Xu R, Chen Y, Zhu W, Yu K.   +8 more
europepmc   +2 more sources

N-Acetylneuraminic Acid Analogues

Journal of Biological Chemistry, 1971
Robert L. McLean, Maitree Suttajit, Janice Beidler, Richard J. Winzler   +3 more
  +4 more sources

Development of N‐acetylneuraminic acid responsive biosensors based on the transcriptional regulator NanR

Biotechnology and Bioengineering, 2018
Gert Peters, Brecht De Paepe, Lien De Wannemaeker, Dries Duchi, J. Maertens, J. Lammertyn, M. De Mey   +6 more
semanticscholar   +3 more sources

The sialidase inhibitor 2,3-dehydro-2-deoxy-N-acetylneuraminic acid is a glucose-dependent potentiator of insulin secretion. [PDF]

Sci Rep, 2020
Minami A, Fujita Y, Shimba S, Shiratori M, Kaneko YK, Sawatani T, Otsubo T, Ikeda K, Kanazawa H, Mikami Y, Sekita R, Kurebayashi Y, Takahashi T, Miyagi T, Ishikawa T, Suzuki T.   +15 more
europepmc   +3 more sources

Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression

Hepatology, EarlyView., 2022
Improved mitochondrial activity, due to the lack of methylation‐controlled J protein (MCJ), creates a specific microbiota signature that when transferred through cecal microbiota transplantation delays NASH progression by restoring the gut‐liver axis and enhancing hepatic fatty acid oxidation.
María Juárez‐Fernández, Naroa Goikoetxea‐Usandizaga, David Porras, María Victoria García‐Mediavilla, Miren Bravo, Marina Serrano‐Maciá, Jorge Simón, Teresa C. Delgado, Sofía Lachiondo‐Ortega, Susana Martínez‐Flórez, Óscar Lorenzo, Mercedes Rincón, Marta Varela‐Rey, Leticia Abecia, Héctor Rodríguez, Juan Anguita, Esther Nistal, María Luz Martínez‐Chantar, Sonia Sánchez‐Campos   +18 more
wiley   +1 more source