Results 51 to 60 of about 15,861 (227)

DataSheet_1_[68Ga]Ga-DOTA-Siglec-9 Detects Pharmacodynamic Changes of FAP-Targeted IL2 Variant Immunotherapy in B16-FAP Melanoma Mice.pdf

, 2022
Vascular adhesion protein-1 (VAP-1) is an inflammation-inducible adhesion molecule, which supports contact between leukocytes and inflamed endothelium.
Olli Moisio (9758723), Helena Virtanen (2796091), Marine Richard (9946448), Xiang-Guo Li (835997), Christian Klein (121710), Heidi Liljenbäck (835998), Tapan Nayak (570788), Riikka Viitanen (13005936), Anne Roivainen (423155), Sirpa Jalkanen (101938), Valeria Nicolini (9706181)   +10 more
core   +1 more source

Regulation of Receptors Siglec-11 and Siglec-15 by MicroRNAs and their Overall Effect on Glioblastoma [PDF]

, 2022
Introduction: Glioblastoma is a fast growing and aggressive type of brain tumour. It is the most common type of brain tumour in adults. Although there are developments in current therapies, patient outcomes remain poor.
Al-Azzawi, Dema
core   +1 more source

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Siglec-15-induced autophagy promotes invasion and metastasis of human osteosarcoma cells by activating the epithelial–mesenchymal transition and Beclin-1/ATG14 pathway

Cell & Bioscience, 2022
Background Pulmonary metastasis is the main cause of poor prognosis in osteosarcoma. Sialic acid-bound immunoglobulin lectin 15 (Siglec-15) has been demonstrated to be obviously correlated with pulmonary metastasis in osteosarcoma patients.
Bingxin Zheng, Keliang Song, Lingling Sun, Yang Gao, Yan Qu, Chongmin Ren, Peng Yan, Wenfang Chen, Wei Guo, Chuanli Zhou, Bin Yue   +10 more
doaj   +1 more source

Siglec-9, a Putative Immune Checkpoint Marker for Cancer Progression Across Multiple Cancer Types

Frontiers in Molecular Biosciences, 2022
Siglec-9, a cell surface transmembrane receptor mainly expressed on B cells, CD56+ NK cells, and CD4+ and CD8+ T cells, is strongly related to the tumor immune microenvironment.
Yuliang Wu, Yuliang Wu, Yuliang Wu, Wei Huang, Wei Huang, Yutong Xie, Chunyan Wang, Ning Luo, Ning Luo, Yingying Chen, Liefu Wang, Zhongping Cheng, Zhongping Cheng, Zhengliang Gao, Zhengliang Gao, Zhengliang Gao, Shupeng Liu, Shupeng Liu   +17 more
doaj   +1 more source

Macrophage PABPC4‐SPP1 Axis Orchestrates Immunosuppression in Colorectal Cancer

Advanced Science, EarlyView.
In the CRC microenvironment, macrophage PABPC4 binds to the 3′UTR of SPP1 mRNA to stabilize its expression, thereby sustaining M2‐like immunosuppressive macrophage polarization. Concurrently, this axis suppresses CD8+ T cell effector functions via CD44 signaling, collectively fostering an immunosuppressive niche that drives tumor progression.
Meng Wang, Fang Yang, Yuan Gao, Liuli Li, Yulan Huang, Hui Yao, Sijie Zhao, Kun Zhao, Tianying Zhang, Hui Heng, Jiaxin Xu, Yuancai Xiang, Weidong Xiao, Shaofan Hu, Hongming Miao   +14 more
wiley   +1 more source

Siglec-1 mediated phagocytosis of promastigotes in macrophages.

, 2016
(A) Sias-siglec dependent phagocytosis was quantitated by flow cytometry. J774A.1 (1× 106/well) cells were grown in a six well plate, either left untreated or blocked with anti-siglec-1 antibody (10 μg/ml) for 1 hr.
Saptarshi Roy (848212), Chitra Mandal (148111)   +1 more
core   +1 more source

Targeting myeloid checkpoint Siglec-10 reactivates antitumor immunity and improves anti-programmed cell death 1 efficacy in gastric cancer

Journal for ImmunoTherapy of Cancer, 2023
Objective Immunotherapy has not yielded satisfactory therapeutic responses in gastric cancer (GC). However, targeting myeloid checkpoints holds promise for expanding the potential of immunotherapy.
Heng Zhang, Chao Lin, Hongyong He, Hao Liu, Ruochen Li, He Li, Jiejie Xu, Fei Shao, Yun Gu, Hanji Fang, Jieti Wang, Kunpeng Lv, Mengyao Sun   +12 more
doaj   +1 more source

Macrophage Trogocytosis of Tumor Cells Drives the Immunosuppression of Tumor Microenvironment

Advanced Science, EarlyView.
Trogocytosis efficiency varies significantly among different tumor cells and is inversely related to their cortical stiffness; this efficiency dictates the extent of immunosuppression via upregulation of CXCL5 and Arg‐1, ultimately driving CD8+T cell exhaustion and tumor escape.
Chao Liang, Jiaqi He, Wan‐Ru Zhuang, Yao Lei, Yanru Jiang, Xianbin Ma, Pan Liu, Zhujun Jiang, Yongheng Li, Hai‐Yan Xie   +9 more
wiley   +1 more source

Role of macrophage sialoadhesin in host defense against the sialylated pathogen group B Streptococcus [PDF]

, 2014
Several bacterial pathogens decorate their surfaces with sialic acid (Sia) residues within cell wall components or capsular exopolysaccharides. Sialic acid expression can promote bacterial virulence by blocking complement activation or by engagement of ...
Joshua Olson, Louie, Aaron, Crocker, Paul R., Victor Nizet, Aaron Louie, Ajit Varki, Paul R. Crocker, Varki, Ajit, Nizet, Victor, Yung-Chi Chang, Chang, Yung-Chi, Olson, Joshua   +11 more
core   +1 more source