Results 71 to 80 of about 15,861 (227)

Contribution of SIGLEC-11 and SIGLEC-16 receptors to neuro-inflammation and neurodegeneration [PDF]

, 2023
Brain aging is a multifactorial process including accumulation of aged lipids and proteins, neuroinflammation and loss of neurons. SIGLEC-11 and SIGLEC-16 are paired opposite inhibitory- versus activatory-signaling receptors on human microglia without ...
Afrang, Negin
core   +1 more source

CD248/Endosialin Regulates Synovial Fibroblast State to Control Coupling of Inflammation and Bone Damage in Murine Models of Immune‐Mediated Inflammatory Arthritis and Aging

Arthritis &Rheumatology, EarlyView.
Objective Synovial fibroblasts directly contribute to inflammation and damage in immune‐mediated inflammatory arthritis. CD248/endosialin is expressed by fibroblasts in the synovium, is highly up‐regulated during inflammation, and has been proposed as a potential therapeutic target.
Samuel Kemble, Corinna Wehmeyer, James M. Brown, Charlotte G. Smith, Holly R. Adams, Eva Crombie, Ellie Northall, Maryam Imran, Paulynn Chin, Harris R. Perlman, Christopher D. Buckley, Adam P. Croft, Amy J. Naylor   +12 more
wiley   +1 more source

Siglec-1 expression by MDMs is enhanced via IFN exposure and leads to VLP internalization.

, 2017
(A) Representative Siglec-1 and tetherin surface expression of GM-CSF matured MDMs together with 24 h IFN alpha stimulation (1000 U/ml). (B) Western blot of Siglec-1 and actin upon incubation with increasing amounts of IFN alpha in GM-CSF derived MDMs ...
Sarah Takushi (3699919), Neal Beeman (3699922), Jason E. Hammonds (3699916), Lingmei Ding (324106), Jaang-Jiun Wang (253626), Gregory B. Melikyan (137795), Paul Spearman (156002), Ashwanth C. Francis (2836463)   +7 more
core   +1 more source

Cysteine Peptidases in Antitumor Immunity: Unraveling Antigen‐Presenting Cell Regulation and Therapeutic Potential

iMetaMed, EarlyView.
This review systematically summarizes the central role of cysteine peptidases in modulating antigen‐presenting cell (APC) function and antitumor immune responses, highlighting their critical significance in overcoming tumor immune evasion. Current research has established that cysteine peptidase subtypes, including cathepsins B, S, L, and X, exert ...
Yimao Wu, Xiaoyan Chen, Zichang Chen, Yalun Liang, Gokhan Zengin, Qian Zhang, Wenlong Sun, Meng‐Yao Li   +7 more
wiley   +1 more source

Sialic acids in pancreatic cancer cells drive tumour-associated macrophage differentiation via the Siglec receptors Siglec-7 and Siglec-9

, 2021
Changes in glycosylation during tumour progression are a key hallmark of cancer. One of the glycan moieties generally overexpressed in cancer are sialic acids, which can induce immunomodulatory properties via binding to Siglec receptors.
van Ee, Thomas, Garcia-Vallejo, Juan J., Schetters, Sjoerd T. T., van Vliet, Sandra J., Kazemier, Geert, Crommentuijn, Matheus H. W., Eveline Li, R. J., van Grieken, Nicole C. T., van Kooyk, Yvette, Boelaars, Kelly, van der Horst, Joost C., Bruijns, Sven C. M., Giovannetti, Elisa, Brown, Kari, Kruijssen, Laura, Rodriguez, Ernesto   +15 more
core   +1 more source

Siglec-H-Deficient Mice Show Enhanced Type I IFN Responses, but Do Not Develop Autoimmunity After Influenza or LCMV Infections

Frontiers in Immunology, 2021
Siglec-H is a DAP12-associated receptor on plasmacytoid dendritic cells (pDCs) and microglia. Siglec-H inhibits TLR9-induced IFN-α production by pDCs. Previously, it was found that Siglec-H-deficient mice develop a lupus-like severe autoimmune disease ...
Nadine Szumilas, Odilia B. J. Corneth, Christian H. K. Lehmann, Christian H. K. Lehmann, Christian H. K. Lehmann, Heike Schmitt, Svenia Cunz, Jolie G. Cullen, Talyn Chu, Anita Marosan, Attila Mócsai, Vladimir Benes, Dietmar Zehn, Diana Dudziak, Diana Dudziak, Diana Dudziak, Rudi W. Hendriks, Lars Nitschke, Lars Nitschke   +18 more
doaj   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Blocking siglec-10hi tumor-associated macrophages improves anti-tumor immunity and enhances immunotherapy for hepatocellular carcinoma

Experimental Hematology & Oncology, 2021
Background Tumor-associated macrophages (TAMs) promote key processes in the modulation of tumor microenvironment (TME). However, the clinical significance of heterogeneous subpopulations of TAMs in hepatocellular carcinoma (HCC) remains unknown.
Nan Xiao, Xiaodong Zhu, Kangshuai Li, Yifan Chen, Xuefeng Liu, Bin Xu, Ming Lei, Jiejie Xu, Hui-Chuan Sun   +8 more
doaj   +1 more source

Analysis of Carbohydrates and Glycoconjugates by Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2023–2024

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley   +1 more source

Basic and Clinical Immunology of Siglecs [PDF]

Annals of the New York Academy of Sciences, 2008
Siglecs are cell‐surface proteins found primarily on hematopoietic cells. By definition, they are members of the immunoglobulin gene super‐family and bind sialic acid. Most contain cytoplasmic tyrosine motifs implicated in cell signaling. This review will first summarize characteristics common and unique to Siglecs, followed by a discussion of each ...
Stephan, von Gunten, Bruce S, Bochner
openaire   +2 more sources