Results 81 to 90 of about 15,861 (227)
Medicinal Research Reviews, EarlyView.ABSTRACT Chitinase‐3‐like‐1 (CHI3L1, also known as YKL‐40) has been recognized as a biomarker of inflammation and tissue remodeling and has now emerged as a pseudoenzymatic immune checkpoint. Recent structural, immunological, and translational studies redefine it as an active regulator of immune suppression rather than a passive disease marker. Despite
Kirti Upmanyu +2 more
wiley +1 more source
The role of lung epithelial ligands for Siglec-8 and Siglec-F in eosinophilic inflammation [PDF]
Current Opinion in Allergy & Clinical Immunology, 2013 Siglec-8 and Siglec-F are single pass transmembrane inhibitory receptors found on the surface of human and mouse eosinophils, respectively, but very little is known about their physiologic glycan ligands. This article reviews the latest knowledge on this topic and outlines the strategies being used to further define the production and glycobiochemical ...
Takumi, Kiwamoto +3 more
openaire +2 more sources
Frontiers in Immunology, 2018 Siglec-9 is an MHC-independent inhibitory receptor selectively expressed on CD56dim NK cells. Its role in infection diseases has not been investigated yet.
Di Zhao +10 more
doaj +1 more source
Chemical and Biological Determinants of PEG‐Lipid Shedding From Therapeutic Nanoparticles
Small, EarlyView.PEG‐lipids play a central role in governing lipid nanoparticle stability, targeting, and function. However, PEG‐lipids can “shed” from the nanoparticle surface in biological environments, with the extent and kinetics of shedding influenced by chemical and biological factors.
Ethan P. Cisneros +2 more
wiley +1 more source
Regulation of airway inflammation by Siglec-8 and Siglec-9 sialoglycan ligand expression [PDF]
Current Opinion in Allergy & Clinical Immunology, 2016 Inflammatory cells involved in the allergic response, including eosinophils, mast cells, basophils, and neutrophils, express sialoglycan-binding proteins such as Siglec-8 and Siglec-9, which inhibit cell function and survival. The purpose of this review is to briefly discuss the biology of these siglecs and their ligands and consider their potential ...
Robert P, Schleimer +2 more
openaire +2 more sources
Smart Molecules, EarlyView.The CD47–SIRPα axis has emerged as a critical innate immune checkpoint that suppresses macrophage‐mediated phagocytosis through a canonical “don't eat me” signal and enables tumor immune evasion. We comprehensively summarize the structural and biological features of CD47 and the molecular mechanisms underlying CD47‐mediated regulation of phagocytosis ...
Ruimei Zhou +4 more
wiley +1 more source
Factor VIII and von Willebrand factor are ligands for the carbohydrate-receptor Siglec-5
Haematologica, 2012 Background Factor VIII (FVIII) and von Willebrand factor (VWF) circulate in plasma in a tight non-covalent complex, being critical to hemostasis. Although structurally unrelated, both share the presence of sialylated glycan-structures, making them ...
Julie N. Pegon +6 more
doaj +1 more source
Expression of ligands for Siglec-8 and Siglec-9 in human airways and airway cells [PDF]
Journal of Allergy and Clinical Immunology, 2015 Balanced activation and inhibition of the immune system ensures pathogen clearance while avoiding hyperinflammation. Siglecs, sialic acid-binding proteins found on subsets of immune cells, often inhibit inflammation: Siglec-8 on eosinophils and Siglec-9 on neutrophils engage sialoglycan ligands on airways to diminish ongoing inflammation.
Yi Jia +12 more
openaire +2 more sources
Dendritic Cell α‐Ketoglutarate Regulates Tfh Polarization in Allergy
Allergy, EarlyView.Allergen induces a dendritic cell metabolism shift toward glutaminolysis with α‐ketoglutarate as a regulator of Tfh subset polarization. Glutaminolysis is required for DC allergen uptake, co‐stimulatory molecule expression, and CLR expression. Modulation of glutaminolysis, JmjD3 histone demethylation, or HIF‐1α degradation alters Tfh polarization and ...
Anuj Tharakan +16 more
wiley +1 more source
Siglec-1 RNAi reduces VCC volumes in HIV-1 NLUdel-infected MDMs.
, 2017 (A) MDMs were infected with VSV-G pseudotyped NLUdel. On the following day, MDMs were transfected with 60 nM scrambled, Siglec-1 or tetherin siRNA. At day 10 post-infection, MDMs were washed, fixed with 4% PFA and immunostained for p24 (green), Siglec-1 (
Sarah Takushi (3699919) +7 more
core +1 more source