Results 21 to 30 of about 15,861 (227)
Siglec-9 blocking antibody characterization.
, 2021 (A) Binding ELISA of anti-Siglec-9 antibody. Recombinant human Siglec-9 protein was used in ELISA to assess the antigen-specific binding of the Siglec-9 blocking antibody. His-tag protein was used as a negative control.
Han Xiao (373894) +16 more
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, 2021 (A) A representative example of depletion of Siglec-9+ NK cells. (B) Siglec-9depleted NK cells exhibit lower cytotoxicity towards HIV-infected HUT78/SF2 targets compared to total NK cells. Cytotoxicity was assessed using NK degranulation, left panel (n =
Han Xiao (373894) +16 more
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The role of Siglec-1 and SR-BI interaction in the phagocytosis of oxidized low density lipoprotein by macrophages. [PDF]
PLoS ONE, 2013 BACKGROUND: Macrophages play a proatherosclerotic role in atherosclerosis via oxLDL uptake. As an adhesion molecular of I-type lectins, Siglec-1 is highly expressed on circulating monocytes and plaque macrophages of atherosclerotic patients, but the ...
Yi-song Xiong +5 more
doaj +1 more source
Siglec-9+ CD56dim NK cells express CD7.
, 2021 Fresh human PBMCs from an HIV-negative donor were stained for CD3, CD56, CD7, and Siglec-9. The majority of Siglec-9+ CD56dim NK cells express CD7, decreasing the chance that these cells are monocytes. FMO = Fluorescence Minus One. (EPS)
Han Xiao (373894) +16 more
core +1 more source
Siglecs and Immune Regulation [PDF]
Annual Review of Immunology, 2012 Sialic acid–binding Ig-like lectins, or Siglecs, vary in their specificity for sialic acid–containing ligands and are mainly expressed by cells of the immune system. Many Siglecs are inhibitory receptors expressed in innate immune cells that regulate inflammation mediated by damage-associated and pathogen-associated molecular patterns (DAMPs and PAMPs).
Shiv, Pillai +3 more
openaire +2 more sources
Pseudaminic acid on Campylobacter jejuni flagella modulates dendritic cell IL-10 expression via Siglec-10 receptor: a novel flagellin-host interaction. [PDF]
, 2014 INTRODUCTION: Campylobacter jejuni is a leading cause of bacterial gastroenteritis worldwide. At present the identity of host-pathogen interactions that promote successful bacterial colonisation remain ill defined.
Crocker, Paul R. +13 more
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Recent progress in targeting the sialylated glycan-SIGLEC axis in cancer immunotherapy
Cancer Biology & Medicine, 2023 Malignant tumors are complex structures composed of cancer cells and tumor microenvironmental cells. In this complex structure, cells cross-talk and interact, thus jointly promoting cancer development and metastasis.
Yingyan Yu, Wenjie Peng
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Siglec-E promotes β2-integrin-dependent NADPH oxidase activation to suppress neutrophil recruitment to the lung [PDF]
, 2014 Siglec-E is a sialic acid-binding Ig-like lectin expressed on murine myeloid cells. It has recently been shown to function as a negative regulator of ß2-integrin-dependent neutrophil recruitment to the lung following exposure to lipopolysaccharide (LPS).
Hegde, Vikas +9 more
core +1 more source
Siglec-14 Enhances NLRP3-Inflammasome Activation in Macrophages
Journal of Innate Immunity, 2019 Pathogenic microorganisms are sensed by the inflammasome, resulting in the release of the pro-immune and proinflammatory cytokine interleukin-1β (IL-1β).
Chih-Ming Tsai +7 more
doaj +1 more source
European Journal of Histochemistry, 2021 The sialic acid-binding immunoglobulin-type lectin Siglec-15 is a promising target to cancer immunotherapy in several tumor types. The present study aimed to investigate Siglec-15 expression in gastric cancer (GC) patient tissue and to evaluate its ...
Michael Williams Leal Quirino +9 more
doaj +1 more source