Results 1 to 10 of about 54,143 (245)

Systematic Review and Meta-Analysis of the Effect of Statins on Circulating E-Selectin, L-Selectin, and P-Selectin

Biomedicines, 2021
The pleiotropic effects of statins might involve preventing inflammatory cell adhesion to the endothelium, which is a critical step in the pathogenesis of atherosclerosis.
, Angelo Zinellu, Mangoni Arduino A
exaly   +3 more sources

E- and P-Selectin: Differences, Similarities and Implications for the Design of P-Selectin Antagonists

CHIMIA, 2011
Selectins form a family of Ca2+-dependent carbohydrate binding proteins that mediate the initial step of leukocyte recruitment in the inflammatory process. Blocking of selectins is therefore considered a promising therapeutic approach to treat acute and chronic inflammatory diseases which are caused by excessive extravasation of leukocytes.
Florian P. C. Binder, Beat Ernst
doaj   +6 more sources

Total and extracellular vesicle–bound plasma P-selectin as diagnostic biomarkers for acute deep vein thrombosis [PDF]

Research and Practice in Thrombosis and Haemostasis
Background: Plasma P-selectin has shown moderate diagnostic potential for deep vein thrombosis (DVT). In plasma, P-selectin is found in soluble form and bound to extracellular vesicles (EVs).
Samantha Xavier, Vårin Eiriksdatter Wikan, Casper J.E. Wahlund, Nadezhda Latysheva, Øyvind Øverli, Christopher Antoun, Thor Ueland, Gholamreza Jafari Yeganeh, Sigrid Kufaas Brækkan, John-Bjarne Hansen, Ellen Brodin, Omri Snir   +11 more
doaj   +2 more sources

P selectin promotes SARS-CoV-2 interactions with platelets and the endothelium [PDF]

The Journal of Clinical Investigation
The physiology of SARS-CoV-2 virus/host interactions is not well understood. To better understand host/virus interactions, we performed a CRISPR activation screen to identify host genes that confer resistance to authentic SARS-CoV-2.
Cesar L. Moreno, Fernanda V.S. Castanheira, Alberto Ospina Stella, Felicity Chung, Anupriya Aggarwal, Alexander J. Cole, Lipin Loo, Alexander Dupuy, Yvonne X. Kong, Lejla Hagimola, Jemma Fenwick, Paul R. Coleman, Rebecca Carr, Tian Y. Du, Tim Ison, Michelle Newton, Maxwell P. Bui-Marinos, Scott B. Cohen, Jennifer A. Corcoran, Daniel Hesselson, Jennifer R. Gamble, Freda H. Passam, Stuart G. Turville, Paul Kubes, G. Gregory Neely   +24 more
doaj   +2 more sources

Soluble P-selectin levels, P-selectin polymorphisms and cardiovascular disease [PDF]

Journal of Thrombosis and Haemostasis, 2003
P-selectin is a member of the selectin family of cell adhesion molecules which are important in the transient attachment of leukocytes to endothelial cells and platelets. A number of polymorphisms in the gene encoding P-selectin have been identified.
P J Grant
exaly   +3 more sources

P-Selectin and Platelet Clearance [PDF]

Blood, 1998
P-selectin is an adhesion receptor for leukocytes expressed by activated platelets and endothelial cells. To assess a possible role of P-selectin in platelet clearance, we adapted an in vivo biotinylation technique in mice. Wild-type and P-selectin–deficient mice were infused with N-hydroxysuccinimido biotin.
Denisa Wagner, Wagner Denisa D
exaly   +5 more sources

P-Selectin Inhibition and the Structure–Activity Relationship of Sea Cucumber-Derived Fucosylated Glycosaminoglycan Oligosaccharides [PDF]

Marine Drugs
The selectin family constitutes a well-known class of immune-regulatory molecules, among which P-selectin has emerged as a therapeutic target for inflammatory thrombotic diseases due to its capacity to mediate the adhesion between multiple immune cell ...
Sujuan Li, Lisha Lin, Lian Yang, Ying Pan, Na Gao, Ronghua Yin, Chunyu Zeng, Jinhua Zhao   +7 more
doaj   +2 more sources

Thrombotic Risk Assessment, P-Selectin, and Thromboprophylaxis Use Among, Cancer Patients at the University of Calabar Teaching Hospital, Calabar [PDF]

Journal of Blood Medicine
Kingsley Akaba,1 Edakabasi Akaba,2 Olukayode Oshatuyi,2 Brian Ssenkumba3 1Department of Haematology, University of Calabar, Calabar, Cross River State, Nigeria; 2Department of Pathology, University of Calabar Teaching Hospital, Calabar, Cross River State,
Akaba K, Akaba E, Oshatuyi O, Ssenkumba B   +3 more
doaj   +2 more sources

Targeted Delivery to Dying Cells Through P-Selectin–PSGL-1 Axis: A Promising Strategy for Enhanced Drug Efficacy in Liver Injury Models [PDF]

Cells
To minimize off-target adverse effects and improve drug efficacy, various tissue-specific drug delivery systems have been developed. However, even in diseased organs, both normal and stressed, dying cells coexist, and a targeted delivery system ...
Te-Sheng Lien, Der-Shan Sun, Hsin-Hou Chang   +2 more
doaj   +2 more sources

The Role of Platelet Cell Surface P-Selectin for the Direct Platelet-Tumor Cell Contact During Metastasis Formation in Human Tumors

Frontiers in Oncology, 2021
Mammalian platelets, devoid of nuclei, are the smallest cells in the blood stream. They are essential for hemostasis, but also transmit cell signals that are necessary for regenerative and generative processes such as inflammation, immunity and tissue ...
Hans-Åke Fabricius, Sarah Starzonek, Tobias Lange   +2 more
doaj   +1 more source