E- and P-Selectin: Differences, Similarities and Implications for the Design of P-Selectin Antagonists [PDF]
CHIMIA, 2011 Selectins form a family of Ca2+-dependent carbohydrate binding proteins that mediate the initial step of leukocyte recruitment in the inflammatory process. Blocking of selectins is therefore considered a promising therapeutic approach to treat acute and chronic inflammatory diseases which are caused by excessive extravasation of leukocytes.
Florian P. C. Binder, Beat Ernst
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Total and extracellular vesicle–bound plasma P-selectin as diagnostic biomarkers for acute deep vein thrombosis [PDF]
Research and Practice in Thrombosis and HaemostasisBackground: Plasma P-selectin has shown moderate diagnostic potential for deep vein thrombosis (DVT). In plasma, P-selectin is found in soluble form and bound to extracellular vesicles (EVs).
Samantha Xavier +11 more
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Thrombotic Risk Assessment, P-Selectin, and Thromboprophylaxis Use Among, Cancer Patients at the University of Calabar Teaching Hospital, Calabar [PDF]
Journal of Blood MedicineKingsley Akaba,1 Edakabasi Akaba,2 Olukayode Oshatuyi,2 Brian Ssenkumba3 1Department of Haematology, University of Calabar, Calabar, Cross River State, Nigeria; 2Department of Pathology, University of Calabar Teaching Hospital, Calabar, Cross River State,
Akaba K +3 more
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Targeted Delivery to Dying Cells Through P-Selectin–PSGL-1 Axis: A Promising Strategy for Enhanced Drug Efficacy in Liver Injury Models [PDF]
CellsTo minimize off-target adverse effects and improve drug efficacy, various tissue-specific drug delivery systems have been developed. However, even in diseased organs, both normal and stressed, dying cells coexist, and a targeted delivery system ...
Te-Sheng Lien +2 more
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Biomedicines, 2021 The pleiotropic effects of statins might involve preventing inflammatory cell adhesion to the endothelium, which is a critical step in the pathogenesis of atherosclerosis.
Angelo Zinellu, Arduino A. Mangoni
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Frontiers in Oncology, 2021 Mammalian platelets, devoid of nuclei, are the smallest cells in the blood stream. They are essential for hemostasis, but also transmit cell signals that are necessary for regenerative and generative processes such as inflammation, immunity and tissue ...
Hans-Åke Fabricius +2 more
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Lung-Derived Selectins Enhance Metastatic Behavior of Triple Negative Breast Cancer Cells
Biomedicines, 2021 The lung is one of the deadliest sites of breast cancer metastasis, particularly for triple negative breast cancer (TNBC). We have previously shown that the lung produces several soluble factors that may enhance the metastatic behavior of TNBC, including
Sami U. Khan +4 more
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A cell-extrinsic ligand acquired by activated T cells in lymph node can bridge L-selectin and P-selectin. [PDF]
PLoS ONE, 2018 P-selectin expressed on activated endothelia and platelets supports recruitment of leukocytes expressing P-selectin ligand to sites of inflammation.
Douglas A Carlow +2 more
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Bromelain decreases neutrophil interactions with P-selectin, but not E-selectin, in vitro by proteolytic cleavage of P-selectin glycoprotein ligand-1. [PDF]
PLoS ONE, 2013 Stem bromelain, a cysteine protease isolated from pineapples, is a natural anti-inflammatory treatment, yet its mechanism of action remains unclear. Curious as to whether bromelain might affect selectin-mediated leukocyte rolling, we studied the ability ...
Jessica M Banks +2 more
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Increased platelet reactivity in idiopathic pulmonary fibrosis is mediated by a plasma factor [PDF]
, 2014 Introduction Idiopathic Pulmonary Fibrosis (IPF) is a progressive, incurable fibrotic interstitial lung disease with a prognosis worse than many cancers. Its pathogenesis is poorly understood.
Crooks, Michael +8 more
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