Results 11 to 20 of about 53,857 (243)

Bromelain decreases neutrophil interactions with P-selectin, but not E-selectin, in vitro by proteolytic cleavage of P-selectin glycoprotein ligand-1. [PDF]

PLoS ONE, 2013
Stem bromelain, a cysteine protease isolated from pineapples, is a natural anti-inflammatory treatment, yet its mechanism of action remains unclear. Curious as to whether bromelain might affect selectin-mediated leukocyte rolling, we studied the ability ...
Jessica M Banks, Christine T Herman, Ryan C Bailey   +2 more
doaj   +1 more source

Soluble P-selectin levels, P-selectin polymorphisms and cardiovascular disease [PDF]

Journal of Thrombosis and Haemostasis, 2003
P-selectin is a member of the selectin family of cell adhesion molecules which are important in the transient attachment of leukocytes to endothelial cells and platelets. A number of polymorphisms in the gene encoding P-selectin have been identified.
A M, Carter, K, Anagnostopoulou, M W, Mansfield, P J, Grant   +3 more
openaire   +2 more sources

Massive expansion of P-selectin genes in two Venerida species, Sinonovacula constricta and Mercenaria mercenaria: evidence from comparative genomics of Bivalvia

BMC Genomics, 2022
Background P-selectin is a molecule participating in the inflammatory response through mediating cellular adhesion and essential for wound repair. However, studies regarding P-selectin in Bivalvia are rare. This study identified 90 P-selectin genes among
Yuanfeng Xu, Xumeng Dong, Shuonan Ma, Cheng Luo, Jilin Xu   +4 more
doaj   +1 more source

P‐selectin in haemostasis [PDF]

British Journal of Haematology, 2004
SummaryDuring the past decade, interrelationships between inflammation and thrombosis have been the subject of extensive works, and it is now commonly recognized that inflammation (notably leucocyte recruitment) directly affects thrombosis, and that thrombosis also constitutes a pro‐inflammatory event.
openaire   +2 more sources

A Novel Glycosulfopeptide Binds to P-selectin and Inhibits Leukocyte Adhesion to P-selectin [PDF]

Journal of Biological Chemistry, 1999
P-selectin glycoprotein ligand-1 (PSGL-1) is a dimeric membrane mucin on leukocytes that binds selectins. The molecular features of PSGL-1 that determine this high affinity binding are unclear. Here we demonstrate the in vitro synthesis of a novel glycosulfopeptide (GSP-6) modeled after the extreme N terminus of PSGL-1, which has been predicted to be ...
A, Leppänen, P, Mehta, Y B, Ouyang, T, Ju, J, Helin, K L, Moore, I, van Die, W M, Canfield, R P, McEver, R D, Cummings   +9 more
openaire   +2 more sources

A functional epitope on P-selectin that supports binding of P-selectin to P-selectin glycoprotein ligand-1 but not to sialyl Lewis X oligosaccharides [PDF]

International Immunology, 1998
P-selectin mediates the adhesion of leukocytes to activated platelets and endothelial cells. To characterize the functional domains of P-selectin for ligand recognition, we established nine hybridoma cell lines secreting anti-rat P-selectin mAb. Among them, the mAb C215 bound both rat and human P-selectins, and inhibited binding of rat and human P ...
M, Hirose, H, Kawashima, M, Miyasaka
openaire   +2 more sources

SELP Asp603Asn and severe thrombosis in COVID-19 males

Journal of Hematology & Oncology, 2021
Thromboembolism is a frequent cause of severity and mortality in COVID-19. However, the etiology of this phenomenon is not well understood. A cohort of 1186 subjects, from the GEN-COVID consortium, infected by SARS-CoV-2 with different severity was ...
Chiara Fallerini, Sergio Daga, Elisa Benetti, Nicola Picchiotti, Kristina Zguro, Francesca Catapano, Virginia Baroni, Simone Lanini, Alessandro Bucalossi, Giuseppe Marotta, Francesca Colombo, Margherita Baldassarri, Francesca Fava, Giada Beligni, Laura Di Sarno, Diana Alaverdian, Maria Palmieri, Susanna Croci, Andrea M. Isidori, Simone Furini, Elisa Frullanti, GEN-COVID Multicenter Study, Alessandra Renieri, Francesca Mari   +23 more
doaj   +1 more source

Glycosylation inhibitors efficiently inhibit P-selectin-mediated cell adhesion to endothelial cells. [PDF]

PLoS ONE, 2014
Adhesion molecules play a critical role in the adhesive interactions of multiple cell types in sickle cell disease (SCD). We previously showed that anti-P-selectin aptamer efficiently inhibits cell adhesion to endothelial cells (ECs) and permits SCD mice
Pushpankur Ghoshal, Mythilypriya Rajendran, Nadine Odo, Tohru Ikuta   +3 more
doaj   +1 more source

Correlation Between P-Selectin Level and Platelet Aggregation in Cerebral Venous Sinus Thrombosis Patients

Majalah Kedokteran Bandung, 2023
One of the causes of cerebral venous sinus thrombosis (CVST) is platelet hyperactivity. Adhesion and secretion are the beginning of platelet activation, which is indicated by a change in the Platelet-selectin (P-selectin) level.
Rahmawati Nurmin, Leni Lismayanti, Tiene Rostini, Agnes Rengga Indrati, Lisda Amalia   +4 more
doaj   +1 more source

Affinity and Kinetic Analysis of P-selectin Binding to P-selectin Glycoprotein Ligand-1 [PDF]

Journal of Biological Chemistry, 1998
Leukocytes use the cell-surface mucin P-selectin glycoprotein ligand-1 (PSGL-1) to tether to and roll on P-selectin on activated endothelial cells and platelets. By using surface plasmon resonance, we measured the affinity and kinetics of binding of soluble monomeric human P-selectin to immobilized PSGL-1 from human neutrophils.
P, Mehta, R D, Cummings, R P, McEver
openaire   +2 more sources