Results 11 to 20 of about 54,143 (245)
Lung-Derived Selectins Enhance Metastatic Behavior of Triple Negative Breast Cancer Cells
Biomedicines, 2021 The lung is one of the deadliest sites of breast cancer metastasis, particularly for triple negative breast cancer (TNBC). We have previously shown that the lung produces several soluble factors that may enhance the metastatic behavior of TNBC, including
Sami U. Khan +4 more
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A cell-extrinsic ligand acquired by activated T cells in lymph node can bridge L-selectin and P-selectin. [PDF]
PLoS ONE, 2018 P-selectin expressed on activated endothelia and platelets supports recruitment of leukocytes expressing P-selectin ligand to sites of inflammation.
Douglas A Carlow +2 more
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Bromelain decreases neutrophil interactions with P-selectin, but not E-selectin, in vitro by proteolytic cleavage of P-selectin glycoprotein ligand-1. [PDF]
PLoS ONE, 2013 Stem bromelain, a cysteine protease isolated from pineapples, is a natural anti-inflammatory treatment, yet its mechanism of action remains unclear. Curious as to whether bromelain might affect selectin-mediated leukocyte rolling, we studied the ability ...
Jessica M Banks +2 more
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BMC Genomics, 2022 Background P-selectin is a molecule participating in the inflammatory response through mediating cellular adhesion and essential for wound repair. However, studies regarding P-selectin in Bivalvia are rare. This study identified 90 P-selectin genes among
Yuanfeng Xu +4 more
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P‐selectin in haemostasis [PDF]
British Journal of Haematology, 2004 SummaryDuring the past decade, interrelationships between inflammation and thrombosis have been the subject of extensive works, and it is now commonly recognized that inflammation (notably leucocyte recruitment) directly affects thrombosis, and that thrombosis also constitutes a pro‐inflammatory event.
openaire +2 more sources
A Novel Glycosulfopeptide Binds to P-selectin and Inhibits Leukocyte Adhesion to P-selectin [PDF]
Journal of Biological Chemistry, 1999 P-selectin glycoprotein ligand-1 (PSGL-1) is a dimeric membrane mucin on leukocytes that binds selectins. The molecular features of PSGL-1 that determine this high affinity binding are unclear. Here we demonstrate the in vitro synthesis of a novel glycosulfopeptide (GSP-6) modeled after the extreme N terminus of PSGL-1, which has been predicted to be ...
A, Leppänen +9 more
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SELP Asp603Asn and severe thrombosis in COVID-19 males
Journal of Hematology & Oncology, 2021 Thromboembolism is a frequent cause of severity and mortality in COVID-19. However, the etiology of this phenomenon is not well understood. A cohort of 1186 subjects, from the GEN-COVID consortium, infected by SARS-CoV-2 with different severity was ...
Chiara Fallerini +23 more
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Iraqi Journal of Hematology, 2020 BACKGROUND: Vascular E- and P-selectins play important roles in sickle cell anemia (SCA), vaso-occlusive crises (VOC); however, the extent to which they determine VOC has not been studied.
Sani Awwalu +6 more
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Glycosylation inhibitors efficiently inhibit P-selectin-mediated cell adhesion to endothelial cells. [PDF]
PLoS ONE, 2014 Adhesion molecules play a critical role in the adhesive interactions of multiple cell types in sickle cell disease (SCD). We previously showed that anti-P-selectin aptamer efficiently inhibits cell adhesion to endothelial cells (ECs) and permits SCD mice
Pushpankur Ghoshal +3 more
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Majalah Kedokteran Bandung, 2023 One of the causes of cerebral venous sinus thrombosis (CVST) is platelet hyperactivity. Adhesion and secretion are the beginning of platelet activation, which is indicated by a change in the Platelet-selectin (P-selectin) level.
Rahmawati Nurmin +4 more
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