E- and P-Selectin: Differences, Similarities and Implications for the Design of P-Selectin Antagonists [PDF]
CHIMIA, 2011 Selectins form a family of Ca2+-dependent carbohydrate binding proteins that mediate the initial step of leukocyte recruitment in the inflammatory process. Blocking of selectins is therefore considered a promising therapeutic approach to treat acute and chronic inflammatory diseases which are caused by excessive extravasation of leukocytes.
Florian P. C. Binder, Beat Ernst
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A cell-extrinsic ligand acquired by activated T cells in lymph node can bridge L-selectin and P-selectin. [PDF]
PLoS ONE, 2018 P-selectin expressed on activated endothelia and platelets supports recruitment of leukocytes expressing P-selectin ligand to sites of inflammation.
Douglas A Carlow +2 more
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Biomedicines, 2021 The pleiotropic effects of statins might involve preventing inflammatory cell adhesion to the endothelium, which is a critical step in the pathogenesis of atherosclerosis.
Angelo Zinellu
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Total and extracellular vesicle–bound plasma P-selectin as diagnostic biomarkers for acute deep vein thrombosis [PDF]
Research and Practice in Thrombosis and HaemostasisBackground: Plasma P-selectin has shown moderate diagnostic potential for deep vein thrombosis (DVT). In plasma, P-selectin is found in soluble form and bound to extracellular vesicles (EVs).
Samantha Xavier +11 more
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P-Selectin and Platelet Clearance [PDF]
Blood, 1998 P-selectin is an adhesion receptor for leukocytes expressed by activated platelets and endothelial cells. To assess a possible role of P-selectin in platelet clearance, we adapted an in vivo biotinylation technique in mice. Wild-type and P-selectin–deficient mice were infused with N-hydroxysuccinimido biotin.
Denisa D Wagner
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P selectin promotes SARS-CoV-2 interactions with platelets and the endothelium [PDF]
The Journal of Clinical InvestigationThe physiology of SARS-CoV-2 virus/host interactions is not well understood. To better understand host/virus interactions, we performed a CRISPR activation screen to identify host genes that confer resistance to authentic SARS-CoV-2.
Cesar L. Moreno +24 more
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P-Selectin Inhibition and the Structure–Activity Relationship of Sea Cucumber-Derived Fucosylated Glycosaminoglycan Oligosaccharides [PDF]
Marine DrugsThe selectin family constitutes a well-known class of immune-regulatory molecules, among which P-selectin has emerged as a therapeutic target for inflammatory thrombotic diseases due to its capacity to mediate the adhesion between multiple immune cell ...
Sujuan Li +7 more
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Thrombotic Risk Assessment, P-Selectin, and Thromboprophylaxis Use Among, Cancer Patients at the University of Calabar Teaching Hospital, Calabar [PDF]
Journal of Blood MedicineKingsley Akaba,1 Edakabasi Akaba,2 Olukayode Oshatuyi,2 Brian Ssenkumba3 1Department of Haematology, University of Calabar, Calabar, Cross River State, Nigeria; 2Department of Pathology, University of Calabar Teaching Hospital, Calabar, Cross River State,
Akaba K +3 more
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Journal of Biological Chemistry, 1993 P-selectin is an adhesion receptor for leukocytes on thrombin-activated platelets and endothelial cells. It contains a NH2-terminal carbohydrate-recognition domain, an epidermal growth factor motif, nine consensus repeats, a transmembrane domain, and a cytoplasmic tail. We expressed two soluble forms of P-selectin, one truncated after the ninth repeat (
Ushiyama, Shigeru +4 more
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P-selectin glycoprotein ligand-1 forms dimeric interactions with E-selectin but monomeric interactions with L-selectin on cell surfaces. [PDF]
PLoS ONE, 2013 Interactions of selectins with cell surface glycoconjugates mediate the first step of the adhesion and signaling cascade that recruits circulating leukocytes to sites of infection or injury.
Yan Zhang +5 more
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