Results 31 to 40 of about 80,651 (264)

تغییرات سرمی E-selectin و P-selectin در مردان مبتلا به نارسایی قلبی پس از هشت هفته تمرین هوازی تداومی و تناوبی [PDF]

مجله دانشگاه علوم پزشکی سبزوار, 2020
زمینه و هدف  مولکول‌های چسبان، نشانگرهای سلولی شناسایی روند تشکیل پلاک آترواسکلروزی دیواره اندوتلیال عروق هستند. هدف، بررسی تغییرات سرمی E-selectin و P-selectin در مردان مبتلا به نارسایی قلبی، پس از هشت هفته تمرین هوازی تداومی و تناوبی بود. مواد و روش‌ها
لادن حسینی ابریشمی, سید محمود حجازی, امیر رشیدلمیر   +2 more
doaj  

Core and shell platelets of a thrombus: A new microfluidic assay to study mechanics and biochemistry

Research and Practice in Thrombosis and Haemostasis, 2020
Background Hemostatic clots have a P‐selectin positive platelet core covered with a shell of P‐selectin negative platelets. Objective To develop a new human blood microfluidic assay to interrogate core/shell mechanics.
Michael E. DeCortin, Lawrence F. Brass, Scott L. Diamond   +2 more
doaj   +1 more source

Nucleosomes and neutrophil extracellular traps in septic and burn patients [PDF]

, 2017
NETosis is a host defense mechanism associated with inflammation and tissue damage. Experimental models show that platelets and von Willebrand factor (VWF) are key elements for intravascular NETosis. We determined NETosis in septic and burn patients at 1
Carestia, Agostina, D'Atri, Lina Paola, Fandiño, María Eugenia, Fondevila, Carlos, Guzman, María Alejandra, Kaufman, Tomás, Magosevich, Débora, Moreno, María Carolina, Schattner, Mirta Ana   +8 more
core   +1 more source

A Novel Glycosulfopeptide Binds to P-selectin and Inhibits Leukocyte Adhesion to P-selectin [PDF]

Journal of Biological Chemistry, 1999
P-selectin glycoprotein ligand-1 (PSGL-1) is a dimeric membrane mucin on leukocytes that binds selectins. The molecular features of PSGL-1 that determine this high affinity binding are unclear. Here we demonstrate the in vitro synthesis of a novel glycosulfopeptide (GSP-6) modeled after the extreme N terminus of PSGL-1, which has been predicted to be ...
A, Leppänen, P, Mehta, Y B, Ouyang, T, Ju, J, Helin, K L, Moore, I, van Die, W M, Canfield, R P, McEver, R D, Cummings   +9 more
openaire   +2 more sources

Rosuvastatin and vascular dysfunction markers in pulmonary arterial hypertension: a placebo-controlled study [PDF]

, 2008
We investigated whether chronic rosuvastatin administration could improve the abnormalities of the circulating levels of vascular dysfunction markers in pulmonary arterial hypertension (PAH).
BARRETO, A.C., CÍCERO, C., LOPES, A.A., MAEDA, N.Y., SOARES, R.P.S.   +4 more
core   +2 more sources

Affinity and Kinetic Analysis of P-selectin Binding to P-selectin Glycoprotein Ligand-1 [PDF]

Journal of Biological Chemistry, 1998
Leukocytes use the cell-surface mucin P-selectin glycoprotein ligand-1 (PSGL-1) to tether to and roll on P-selectin on activated endothelial cells and platelets. By using surface plasmon resonance, we measured the affinity and kinetics of binding of soluble monomeric human P-selectin to immobilized PSGL-1 from human neutrophils.
P, Mehta, R D, Cummings, R P, McEver
openaire   +2 more sources

Effects of oxidized low density lipoprotein, lipid mediators and statins on vascular cell interactions [PDF]

, 1999
The integrin heterodimer CD11b/CD18 (alpha M beta 2, Mac-1, CR3) expressed on monocytes or polymorphonuclear leukocytes (PMN) is a receptor for iC3b, fibrinogen, heparin, and for intercellular adhesion molecule (ICAM)-1 on endothelium, crucially ...
Amatruda TT, Bednar MM, Bellosta S, Buttrum SM, Buyon JP, Calara F, Calderon TM, Diacovo TG, Giroux LM, Jukema JW, Kim JA, Kimura M, Laufs U, Laws KH, Lehr H-A, Marcus AJ, Notabartolo A, Olstrowsky L, Pons F, Ruf A, Smalley DM, Stragliotto E, Sugiyama S, Weber C, Weber C, Weber C, Yeagle PL, Yeo EL, Yue TL   +28 more
core   +1 more source

Force-dependent calcium signaling and its pathway of human neutrophils on P-selectin in flow

Protein & Cell, 2017
P-selectin engagement of P-selectin glycoprotein ligand-1 (PSGL-1) causes circulating leukocytes to roll on and adhere to the vascular surface, and mediates intracellular calcium flux, a key but unclear event for subsequent arresting firmly at and ...
Bing Huang, Yingchen Ling, Jiangguo Lin, Xin Du, Ying Fang, Jianhua Wu   +5 more
doaj   +1 more source

Heterotrimeric G-protein subunit Gαi2 contributes to agonist-sensitive apoptosis and degranulation in murine platelets [PDF]

, 2018
Gαi2, a heterotrimeric G-protein subunit, regulates various cell functions including ion channel activity, cell differentiation, proliferation and apoptosis.
Birnbaumer, Lutz, Bissinger, Rosi, Cao, Hang, Gawaz, Meinrad, Lang, Elisabeth, Lang, Florian, Leiss, Veronika, Nürnberg, Bernd, Pelzl, Lisann, Pieske, Burkert, Qadri, Syed M., Umbach, Anja T., Voelkl, Jakob   +12 more
core   +1 more source

Effect of PSI-697, a novel P-selectin inhibitor, on platelet-monocyte aggregate formation in humans [PDF]

, 2013
Background: Platelet activation is central to the pathogenesis of acute coronary syndromes. Surface expression of P‐selectin on activated platelets induces formation of platelet–monocyte aggregates and promotes vascular inflammation and thrombosis.
Burt, David, Chelliah, Raj, Connolly, Thomas M, Feuerstein, Giora Z, Fox, Keith A A, Japp, Alan G, Katz, Arie, Lang, Ninian N, Meng, Xu, Newby, David E, Tattersall, Laura, Weisel, Kathleen   +11 more
core   +1 more source