Results 21 to 30 of about 54,143 (245)

Effects of astragalus polysaccharide on the adhesion-related immune response of endothelial cells stimulated with CSFV in vitro [PDF]

PeerJ, 2017
Background Astragalus polysaccharide (APS) has immunomodulatory activities on porcine peripheral blood mononuclear cells. The immunomodulatory effects of APS on porcine endothelial cells (ECs) expose to classical swine fever virus (CSFV) remain unknown ...
Zengyu Zhuge, Yanpeng Dong, Liuan Li, Tianming Jin   +3 more
doaj   +2 more sources

A functional epitope on P-selectin that supports binding of P-selectin to P-selectin glycoprotein ligand-1 but not to sialyl Lewis X oligosaccharides [PDF]

International Immunology, 1998
P-selectin mediates the adhesion of leukocytes to activated platelets and endothelial cells. To characterize the functional domains of P-selectin for ligand recognition, we established nine hybridoma cell lines secreting anti-rat P-selectin mAb. Among them, the mAb C215 bound both rat and human P-selectins, and inhibited binding of rat and human P ...
M, Hirose, H, Kawashima, M, Miyasaka
openaire   +2 more sources

Plasma P-selectin level is associated with severity of coronary heart disease in Chinese Han population

Journal of International Medical Research, 2020
Objective This study aimed to evaluate the association between plasma P-selectin levels and the severity of coronary heart disease (CHD) in a Chinese Han population.
Chunhui Song, Guohai Wu, Sheng Chang, Lizhan Bie   +3 more
doaj   +1 more source

Affinity and Kinetic Analysis of P-selectin Binding to P-selectin Glycoprotein Ligand-1 [PDF]

Journal of Biological Chemistry, 1998
Leukocytes use the cell-surface mucin P-selectin glycoprotein ligand-1 (PSGL-1) to tether to and roll on P-selectin on activated endothelial cells and platelets. By using surface plasmon resonance, we measured the affinity and kinetics of binding of soluble monomeric human P-selectin to immobilized PSGL-1 from human neutrophils.
P, Mehta, R D, Cummings, R P, McEver
openaire   +2 more sources

The vimentin rod domain blocks P-selectin-P-selectin glycoprotein ligand 1 interactions to attenuate leukocyte adhesion to inflamed endothelium.

PLoS ONE, 2020
Acute inflammation begins with leukocyte P-selectin glycoprotein ligand-1 (PSGL-1) binding to P-selectin on inflamed endothelium and platelets. In pathologic conditions, this process may contribute to secondary organ damage, like sepsis-induced liver ...
Fong Wilson Lam, Cameron August Brown, Christian Valladolid, Dabel Cynthia Emebo, Timothy Gerald Palzkill, Miguel Angel Cruz   +5 more
doaj   +1 more source

تغییرات سرمی E-selectin و P-selectin در مردان مبتلا به نارسایی قلبی پس از هشت هفته تمرین هوازی تداومی و تناوبی [PDF]

مجله دانشگاه علوم پزشکی سبزوار, 2020
زمینه و هدف  مولکول‌های چسبان، نشانگرهای سلولی شناسایی روند تشکیل پلاک آترواسکلروزی دیواره اندوتلیال عروق هستند. هدف، بررسی تغییرات سرمی E-selectin و P-selectin در مردان مبتلا به نارسایی قلبی، پس از هشت هفته تمرین هوازی تداومی و تناوبی بود. مواد و روش‌ها
لادن حسینی ابریشمی, سید محمود حجازی, امیر رشیدلمیر   +2 more
doaj  

Biodistribution of P-selectin targeted microbubbles [PDF]

Journal of Drug Targeting, 2014
To evaluate binding of P-selectin targeted microbubbles (MB) in tumor vasculature; a whole-body imaging and biodistribution study was performed in a tumor bearing mouse model.Antibodies were radiolabeled with Tc-99 m using the HYNIC method. Tc-99 m labeled anti-P-selectin antibodies were avidin-bound to lipid-shelled, perfluorocarbon gas-filled MB and ...
Jason M, Warram, Anna G, Sorace, Marshall, Mahoney, Sharon, Samuel, Bryant, Harbin, Madhura, Joshi, Amber, Martin, Lee, Whitworth, Kenneth, Hoyt, Kurt R, Zinn   +9 more
openaire   +2 more sources

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Core and shell platelets of a thrombus: A new microfluidic assay to study mechanics and biochemistry

Research and Practice in Thrombosis and Haemostasis, 2020
Background Hemostatic clots have a P‐selectin positive platelet core covered with a shell of P‐selectin negative platelets. Objective To develop a new human blood microfluidic assay to interrogate core/shell mechanics.
Michael E. DeCortin, Lawrence F. Brass, Scott L. Diamond   +2 more
doaj   +1 more source

Circulating selectins as potential biomarkers for sarcopenia: a case-control study

Frontiers in Medicine
BackgroundThis study investigates the association between circulating E-selectin, L-selectin, and P-selectin levels and sarcopenia in older adults.MethodsWe conducted a case-control study of 325 older adults (261 controls, 64 sarcopenia cases ...
Hu Zhang, Huaqing Liu, Yanhui Tang, Jiatong Wu, Mingyang Du, Yanhua Song, Nannan Wang, Jianfeng Wang   +7 more
doaj   +1 more source