Results 21 to 30 of about 53,857 (243)

Effects of astragalus polysaccharide on the adhesion-related immune response of endothelial cells stimulated with CSFV in vitro [PDF]

PeerJ, 2017
Background Astragalus polysaccharide (APS) has immunomodulatory activities on porcine peripheral blood mononuclear cells. The immunomodulatory effects of APS on porcine endothelial cells (ECs) expose to classical swine fever virus (CSFV) remain unknown ...
Zengyu Zhuge, Yanpeng Dong, Liuan Li, Tianming Jin   +3 more
doaj   +2 more sources

Soluble P- and E-selectin levels as determinants of vaso-occlusive crises among sickle cell anemia patients in a tertiary hospital Northwestern Nigeria

Iraqi Journal of Hematology, 2020
BACKGROUND: Vascular E- and P-selectins play important roles in sickle cell anemia (SCA), vaso-occlusive crises (VOC); however, the extent to which they determine VOC has not been studied.
Sani Awwalu, Abdulaziz Hassan, Aisha Indo Mamman, Abdul Wahab Alhassan, Ismaila Nda Ibrahim, Ibrahim Usman Kusfa, Aliyu Dahiru Waziri   +6 more
doaj   +1 more source

Plasma P-selectin level is associated with severity of coronary heart disease in Chinese Han population

Journal of International Medical Research, 2020
Objective This study aimed to evaluate the association between plasma P-selectin levels and the severity of coronary heart disease (CHD) in a Chinese Han population.
Chunhui Song, Guohai Wu, Sheng Chang, Lizhan Bie   +3 more
doaj   +1 more source

Biodistribution of P-selectin targeted microbubbles [PDF]

Journal of Drug Targeting, 2014
To evaluate binding of P-selectin targeted microbubbles (MB) in tumor vasculature; a whole-body imaging and biodistribution study was performed in a tumor bearing mouse model.Antibodies were radiolabeled with Tc-99 m using the HYNIC method. Tc-99 m labeled anti-P-selectin antibodies were avidin-bound to lipid-shelled, perfluorocarbon gas-filled MB and ...
Jason M, Warram, Anna G, Sorace, Marshall, Mahoney, Sharon, Samuel, Bryant, Harbin, Madhura, Joshi, Amber, Martin, Lee, Whitworth, Kenneth, Hoyt, Kurt R, Zinn   +9 more
openaire   +2 more sources

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

The vimentin rod domain blocks P-selectin-P-selectin glycoprotein ligand 1 interactions to attenuate leukocyte adhesion to inflamed endothelium.

PLoS ONE, 2020
Acute inflammation begins with leukocyte P-selectin glycoprotein ligand-1 (PSGL-1) binding to P-selectin on inflamed endothelium and platelets. In pathologic conditions, this process may contribute to secondary organ damage, like sepsis-induced liver ...
Fong Wilson Lam, Cameron August Brown, Christian Valladolid, Dabel Cynthia Emebo, Timothy Gerald Palzkill, Miguel Angel Cruz   +5 more
doaj   +1 more source

تغییرات سرمی E-selectin و P-selectin در مردان مبتلا به نارسایی قلبی پس از هشت هفته تمرین هوازی تداومی و تناوبی [PDF]

مجله دانشگاه علوم پزشکی سبزوار, 2020
زمینه و هدف  مولکول‌های چسبان، نشانگرهای سلولی شناسایی روند تشکیل پلاک آترواسکلروزی دیواره اندوتلیال عروق هستند. هدف، بررسی تغییرات سرمی E-selectin و P-selectin در مردان مبتلا به نارسایی قلبی، پس از هشت هفته تمرین هوازی تداومی و تناوبی بود. مواد و روش‌ها
لادن حسینی ابریشمی, سید محمود حجازی, امیر رشیدلمیر   +2 more
doaj  

Core and shell platelets of a thrombus: A new microfluidic assay to study mechanics and biochemistry

Research and Practice in Thrombosis and Haemostasis, 2020
Background Hemostatic clots have a P‐selectin positive platelet core covered with a shell of P‐selectin negative platelets. Objective To develop a new human blood microfluidic assay to interrogate core/shell mechanics.
Michael E. DeCortin, Lawrence F. Brass, Scott L. Diamond   +2 more
doaj   +1 more source

Force-dependent calcium signaling and its pathway of human neutrophils on P-selectin in flow

Protein & Cell, 2017
P-selectin engagement of P-selectin glycoprotein ligand-1 (PSGL-1) causes circulating leukocytes to roll on and adhere to the vascular surface, and mediates intracellular calcium flux, a key but unclear event for subsequent arresting firmly at and ...
Bing Huang, Yingchen Ling, Jiangguo Lin, Xin Du, Ying Fang, Jianhua Wu   +5 more
doaj   +1 more source

Two by two: The pairings of P-selectin and P-selectin glycoprotein ligand 1 [PDF]

Proceedings of the National Academy of Sciences, 2001
Targeting of circulating leukocytes to specific areas of microbial invasion or tissue injury is critical for host defense and wound repair. If it is defective, syndromes of cellular immune deficiency result; conversely, if targeting is uncontrolled or dysregulated, accumulation of leukocytes may cause inflammatory tissue damage (1–3).
openaire   +2 more sources