E-selectin in vascular pathophysiology [PDF]
Frontiers in ImmunologySelectins are a group of Ca2+-dependent, transmembrane type I glycoproteins which attract cell adhesion and migration. E-selectin is exclusively expressed in endothelial cells, and its expression is strongly enhanced upon activation by pro-inflammatory ...
Jinjin Zhang +9 more
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Expression of E–Selectin and E–Selectin Ligands in Human Liver Inflammation [PDF]
Hepatology, 1996 Lymphocyte recruitment to tissue is regulated by homing molecules expressed on subsets of leukocytes that bind to endothelial adhesion molecules termed addressins in target tissues. The addressins and homing molecules involved in recruiting lymphocytes to inflamed human liver are not known.
D H, Adams +4 more
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Biomedicines, 2021 The pleiotropic effects of statins might involve preventing inflammatory cell adhesion to the endothelium, which is a critical step in the pathogenesis of atherosclerosis.
Angelo Zinellu, Arduino A. Mangoni
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E-selectin-targeted microbubbles combined with ultrasound improves renoprotective effects of methylprednisolone on cisplatin-induced acute kidney injury in rats [PDF]
Scientific ReportsOur previous study showed that the functionalized E-selectin targeted MBs (TMB-E−selectin) may become a novel drug delivery vector for inflammatory diseases.
Ruoyan Si +7 more
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The biology of E-selectin ligands in leukemogenesis. [PDF]
Adv Cancer Res, 2023 Both the cascade whereby a blood-borne cell enters a tissue and the anchoring of hematopoietic stem/progenitor cells (HSPCs) within bone marrow critically pivots on cell-cell interactions mediated by E-selectin binding to its canonical carbohydrate ligand, the tetrasaccharide termed "sialylated Lewis X" (sLeX).
Ales E, Sackstein R.
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PSGL-1 decorated with sialyl Lewisa/x promotes high affinity binding of myeloma cells to P-selectin but is dispensable for E-selectin engagement [PDF]
Scientific ReportsDissemination of multiple myeloma into the bone marrow proceeds through sequential steps mediated by a variety of adhesion molecules and chemokines that eventually results in the extravasation of malignant plasma cells into this protective niche ...
Michael O’Dwyer +4 more
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Mac-2 binding protein is a novel E-selectin ligand expressed by breast cancer cells. [PDF]
PLoS ONE, 2012 Hematogenous metastasis involves the adhesion of circulating tumor cells to vascular endothelium of the secondary site. We hypothesized that breast cancer cell adhesion is mediated by interaction of endothelial E-selectin with its glycoprotein counter ...
Venktesh S Shirure +2 more
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CD44v4 is a major E-selectin ligand that mediates breast cancer cell transendothelial migration. [PDF]
PLoS ONE, 2008 BACKGROUND: Endothelial E-selectin has been shown to play a pivotal role in mediating cell-cell interactions between breast cancer cells and endothelial monolayers during tumor cell metastasis.
Ke Zen +7 more
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Circulating tumor cells from prostate cancer patients interact with E-selectin under physiologic blood flow. [PDF]
PLoS ONE, 2013 Hematogenous metastasis accounts for the majority of cancer-related deaths, yet the mechanism remains unclear. Circulating tumor cells (CTCs) in blood may employ different pathways to cross blood endothelial barrier and establish a metastatic niche ...
Gunjan Gakhar +13 more
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Intranasal delivery of E-selectin reduces atherosclerosis in ApoE-/- mice. [PDF]
PLoS ONE, 2011 Mucosal tolerance to E-selectin prevents stroke and protects against ischemic brain damage in experimental models of stroke studying healthy animals or spontaneously hypertensive stroke-prone rats.
Xinhui Li +8 more
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