Results 1 to 10 of about 50,139,323 (325)

E-Selectin and SDF-1 regulate metastatic trafficking of breast cancer cells within the bone

Molecular & Cellular Oncology, 2017
E-selectin is a key mediator of breast cancer cell (BCC) metastatic entry into the bone and stromal-derived factor 1 (SDF-1) is a critical molecular anchor for BCCs within discrete pro-dormancy bone marrow (BM) niches.
Trevor T. Price, Dorothy A. Sipkins
doaj   +1 more source

E-selectin ligands as mechanosensitive receptors on neutrophils in health and disease

Annals of Biomedical Engineering, 2012
Application of mechanical force to bonds between selectins and their ligands is a requirement for these adhesion receptors to optimally perform functions that include leukocyte tethering and activation of stable adhesion. Although all three selectins are
S. Chase, J. Magnani, S. Simon
semanticscholar   +1 more source

E-selectin liposomal and nanotube-targeted delivery of doxorubicin to circulating tumor cells

Journal of Controlled Release, 2012
The presence of circulating tumor cells (CTCs) is believed to lead to the formation of secondary tumors via an adhesion cascade involving interaction between adhesion receptors of endothelial cells and ligands on CTCs.
M. J. Mitchell, Christina S Chen, Varun Ponmudi, A. D. Hughes, M. King   +4 more
semanticscholar   +1 more source

Serum Profiling of Proinflammatory Mediators in Inflammatory Bowel Disease: Indication for Use in Differential Diagnosis

Applied Sciences
Inflammatory Bowel Disease (IBD) is a group of chronic intestinal diseases, among which Crohn’s disease (CD) and ulcerative colitis (UC) represent the two main types.
Aleksandra Górecka, Grzegorz Wisowski, Yoana Kisselova-Kaneva, Diana Ivanova, Paweł Olczyk, Katarzyna Komosinska-Vassev   +5 more
doaj   +1 more source

Shear Stress Modulation of IL-1β-Induced E-Selectin Expression in Human Endothelial Cells

PLoS ONE, 2012
Background Endothelial cells (ECs) are continuously exposed to hemodynamic forces imparted by blood flow. While it is known that endothelial behavior can be influenced by cytokine activation or fluid shear, the combined effects of these two independent ...
Ryan B. Huang, O. Eniola-Adefeso
semanticscholar   +1 more source

Vascular Endothelial Growth Factor Expression of Intercellular Adhesion Molecule 1 (ICAM-1), Vascular Cell Adhesion Molecule 1 (VCAM-1), and E-selectin through Nuclear Factor-κB Activation in Endothelial Cells*

Journal of Biological Chemistry, 2001
Vascular endothelial growth factor (VEGF) induces adhesion molecules on endothelial cells during inflammation. Here we examined the mechanisms underlying VEGF-stimulated expression of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion ...
Injune Kim, S. Moon, Sung Hoon Kim, Hyung Jin Kim, Young Soon Koh, Gou Young Koh   +5 more
semanticscholar   +1 more source

Complementary targeting of liposomes to IL-1α and TNF-α activated endothelial cells via the transient expression of VCAM1 and E-selectin.

Biomaterials, 2011
Inflammation is in part defined by the transient upregulation of cell adhesion molecules on the surface of endothelial cells (ECs) in response to cytokines.
Rico C. Gunawan, D. Almeda, D. Auguste
semanticscholar   +1 more source

Serum Concentration and Chemotactic Activity of E-selectin (CD62E) in Inflammatory Bowel Disease

Mediators of Inflammation, 1994
E-selectin (CD62E) is an endothelial specific glycoprotein belonging to the selectin family of adhesion molecules. Because a high expression of this molecule at intestinal mucosal surfaces in inflammatory bowel disease (IBD) has been described earlier ...
B. Vainerc, O. H. Nielsen
doaj   +1 more source

Direct Measurements on CD24-Mediated Rolling of Human Breast Cancer MCF-7 Cells on E-selectin

Analytical Chemistry, 2011
Tumor cell rolling on the endothelium plays a key role in the initial steps of cancer metastasis, i.e. extravasation of circulating tumor cells (CTCs).
J. Myung, K. Gajjar, Ryan M. Pearson, C. Launiere, D. Eddington, Seungpyo Hong   +5 more
semanticscholar   +1 more source

Assessment of the influence of Leu554Phe genetic variants of the SELE gene to the clinical manifestation of ankylosing spondylitis and cardiovascular risk factors

Клинический разбор в общей медицине
Aim. To assess the impact of the Leu554Phe polymorphism of the SELE gene on clinical characteristics and cardiovascular risk in patients with ankylosing spondylitis. Materials and methods.
Anife S. Gaffarova, Vladimir A. Beloglazov, Igor A. Yatskov, Elizaveta S. Ageeva, Andrey V. Petrov, Anna A. Zayaeva   +5 more
doaj   +1 more source