Results 11 to 20 of about 52,061 (244)
Biomedicines, 2022 E-selectin is an endothelial cell adhesion molecule involved in vascular inflammation. Elevated E-selectin has been reported in patients with high blood pressure and diabetes.
Dana Mihaela Ciobanu +4 more
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Bromelain decreases neutrophil interactions with P-selectin, but not E-selectin, in vitro by proteolytic cleavage of P-selectin glycoprotein ligand-1. [PDF]
PLoS ONE, 2013 Stem bromelain, a cysteine protease isolated from pineapples, is a natural anti-inflammatory treatment, yet its mechanism of action remains unclear. Curious as to whether bromelain might affect selectin-mediated leukocyte rolling, we studied the ability ...
Jessica M Banks +2 more
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Affinity, Kinetics, and Thermodynamics of E-selectin Binding to E-selectin Ligand-1 [PDF]
Journal of Biological Chemistry, 2001 E-selectin is an endothelial adhesion molecule, which mediates the tethering and rolling of leukocytes on vascular endothelium. It recognizes the glycoprotein E-selectin ligand-1 (ESL-1) as a major binding partner on mouse myeloid cells. Using surface plasmon resonance, we measured the kinetics and affinity of binding of monomeric E-selectin to ESL-1 ...
Wild, M +4 more
openaire +2 more sources
Arterial Hypertension, 2022 BACKGROUND: Elevated soluble E-selectin which reflects a state of endothelial activation with subsequent vasoconstriction may elevate morning blood pressure (BP) surge.
Mohamed Yahia Abd Alkhalik +2 more
doaj +1 more source
Molecules, 2015 In this study, we cloned the full-length cDNA of E-selectin of zebrafish (Danio rerio), analyzed its expression pattern and preliminarily explored its biological function.
Guijin Sun +5 more
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P-selectin glycoprotein ligand-1 forms dimeric interactions with E-selectin but monomeric interactions with L-selectin on cell surfaces. [PDF]
PLoS ONE, 2013 Interactions of selectins with cell surface glycoconjugates mediate the first step of the adhesion and signaling cascade that recruits circulating leukocytes to sites of infection or injury.
Yan Zhang +5 more
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Frontiers in Immunology, 2017 Selectins guide the traffic of activated T-cells through the blood stream by mediating their tethering and rolling onto inflamed endothelium, in this way acting as beacons to help navigate them to sites of inflammation.
Amal J. Ali +2 more
doaj +1 more source
PLoS ONE, 2010 Active targeting of a drug carrier to a specific target site is crucial to provide a safe and efficient delivery of therapeutics and imaging contrast agents.
Aman P Mann +8 more
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L1CAM as an E-selectin Ligand in Colon Cancer [PDF]
International Journal of Molecular Sciences, 2020 Metastasis is the main cause of death among colorectal cancer (CRC) patients. E-selectin and its carbohydrate ligands, including sialyl Lewis X (sLeX) antigen, are key players in the binding of circulating tumor cells to the endothelium, which is one of the major events leading to organ invasion. Nevertheless, the identity of the glycoprotein scaffolds
Fanny M. Deschepper +8 more
openaire +5 more sources
Staining of E-selectin ligands on paraffin-embedded sections of tumor tissue
BMC Cancer, 2018 Background The E-selectin ligands expressed by cancer cells mediate adhesion of circulating cancer cells to endothelial cells, as well as within tissue microenvironments important for tumor progression and metastasis.
Mylène A. Carrascal +9 more
doaj +1 more source