Results 31 to 40 of about 76,202 (273)

Staining of E-selectin ligands on paraffin-embedded sections of tumor tissue

BMC Cancer, 2018
Background The E-selectin ligands expressed by cancer cells mediate adhesion of circulating cancer cells to endothelial cells, as well as within tissue microenvironments important for tumor progression and metastasis.
Mylène A. Carrascal, Catarina Talina, Paula Borralho, A. Gonçalo Mineiro, Ana Raquel Henriques, Cláudia Pen, Manuela Martins, Sofia Braga, Robert Sackstein, Paula A. Videira   +9 more
doaj   +1 more source

Endothelial preconditioning by transient oxidative stress reduces inflammatory responses of cultured endothelial cells to TNF-α [PDF]

, 2000
Brief episodes of ischemia can render an organ resistant to subsequent severe ischemia. This ‘ischemic preconditioning’ is ascribed to various mechanisms, including oxidative stress. We investigated whether preconditioning exists on an endothelial level.
Akimitsu T., BERNHARD F. BECKER, CHRISTIAN KUPATT, DeFily D. V., Hearse D. J., Hoshida S., Jerome S. N., Schreck R., Schulz R., Siegfried M. R., STEFAN ZAHLER, Yao Z.   +11 more
core   +1 more source

Characterization of equine E‐selectin

Immunology, 2001
SummaryExpression of E‐selectin on activated endothelium is a critical initial step that leads to extravasation of leucocytes during inflammation, yet E‐selectin is largely uncharacterized in several animal species including the horse. We have sequenced and compared E‐selectin genes derived from activated cultures of purified equine (horse), cervid ...
J F, Hedges, C D, Demaula, B D, Moore, B E, McLaughlin, S I, Simon, N J, MacLachlan   +5 more
openaire   +3 more sources

Air temperature and inflammatory and coagulation responses in men with coronary or pulmonary disease during the winter season [PDF]

, 2010
Background and Objective Air temperature changes are associated with increased cardiovascular and respiratory risk, but the roles of inflammatory and coagulation markers are not well understood.
Breitner, Susanne, Frampton, Mark W., Hampel, Regina, Koenig, Wolfgang, Peters, Annette, Phipps, Richard P., Rückerl, Regina, Schneider, Alexandra, Wichmann, Heinz-Erich   +8 more
core   +1 more source

Serum and cerebrospinal fluid concentrations of E-selectin in patients with aneurysmal subarachnoid hemorrhage

Brazilian Journal of Medical and Biological Research, 2005
The goal of the present study was to determine concentrations of E-selectin in both cerebrospinal fluid (CSF) and serum of patients with aneurysmal subarachnoid hemorrhage (SAH) and to evaluate the correlation between the clinical parameters and E ...
T. Tanriverdi, G.Z. Sanus, M.O. Ulu, E. Tureci, H. Uzun, S. Aydin, M.Y. Kaynar   +6 more
doaj   +1 more source

Intratracheal administration of endotoxin and cytokines: VIII. LPS induces E-selectin expression; anti-E-selectin and soluble E-selectin inhibit acute inflammation [PDF]

Inflammation, 1994
E-selectin is an inducible endothelial adhesion molecule that binds neutrophils. E-selectin mRNA is not constitutively detectable in the lungs of rats. Intratracheal injection of LPS induces pulmonary E-selectin mRNA expression at 2-4 h. Intratracheal injection of LPS followed at 2 and 4 h by intravenous injection of mouse F(ab')2 or F(ab') anti-E ...
Collins, Tucker, Yi, Eunhee S., Guo, Kaizhi, Williams, James H., Steininger, Christina N., Welply, Joseph K., Keene, Jeffery L., Schmuke, Jon J., Ulich, Thomas R., Howard, Susan C., Remick, Daniel G., Yin, Songmei   +11 more
openaire   +3 more sources

Targeting E-selectin to Tackle Cancer Using Uproleselan [PDF]

Cancers, 2021
E-selectin is a vascular adhesion molecule expressed mainly on endothelium, and its primary role is to facilitate leukocyte cell trafficking by recognizing ligand surface proteins. E-selectin gained a new role since it was demonstrated to be involved in cancer cell trafficking, stem-like properties and therapy resistance.
Barbara Muz, Anas Abdelghafer, Matea Markovic, Jessica Yavner, Anupama Melam, Noha Nabil Salama, Abdel Kareem Azab   +6 more
openaire   +3 more sources

Skap2 is required for β2 integrin-mediated neutrophil recruitment and functions. [PDF]

, 2017
Integrin activation is required for neutrophil functions. Impaired integrin activation on neutrophils is the hallmark of leukocyte adhesion deficiency (LAD) syndrome in humans, characterized by impaired leukocyte recruitment and recurrent infections. The
Bardel, Bernadette, Block, Helena, Bokemeyer, Arne, Boras, Mark, Heitplatz, Barbara, Kliche, Stefanie, Lowell, Clifford, Reinhold, Annegret, Rossaint, Jan, Van Marck, Veerle, Volmering, Stephanie, Zarbock, Alexander   +11 more
core   +2 more sources

Mucosal Administration of E-selectin Limits Disability in Models of Multiple Sclerosis

Frontiers in Molecular Neuroscience, 2019
E-selectin plays an important role in mediating the rolling of leukocytes along and thus, the subsequent extravasation across activated endothelial cells comprising the microvasculature of the blood brain barrier (BBB).
Jacqueline A. Quandt, Pierre Becquart, Emily Kamma, John Hallenbeck   +3 more
doaj   +1 more source

E-selectin mediated adhesion and migration of endothelial colony forming cells is enhanced by SDF-1α/CXCR4. [PDF]

PLoS ONE, 2013
OBJECTIVE: Endothelial-colony forming cells (ECFCs) can be readily expanded from human umbilical cord blood and can facilitate repair of endothelial injury.
Jie Sun, Yuhua Li, Gina M Graziani, Lionel Filion, David S Allan   +4 more
doaj   +1 more source