Results 31 to 40 of about 50,139,323 (325)

Targeting E-selectin to Tackle Cancer Using Uproleselan

Cancers, 2021
Simple Summary This review focuses on eradicating cancer by targeting a surface protein expressed on the endothelium—E-selectin—with a novel drug, uproleselan (GMI-1271).
B. Muz, Anas Abdelghafer, Matea Markovic, Jessica Yavner, Anupama Melam, N. Salama, A. Azab   +6 more
semanticscholar   +1 more source

CD44v4 is a major E-selectin ligand that mediates breast cancer cell transendothelial migration. [PDF]

PLoS ONE, 2008
BACKGROUND: Endothelial E-selectin has been shown to play a pivotal role in mediating cell-cell interactions between breast cancer cells and endothelial monolayers during tumor cell metastasis.
Ke Zen, Dan-Qing Liu, Ya-Lan Guo, Chen Wang, Jun Shan, Ming Fang, Chen-Yu Zhang, Yuan Liu   +7 more
doaj   +1 more source

Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance

Nature Communications, 2020
The endothelial cell adhesion molecule E-selectin is a key component of the bone marrow hematopoietic stem cell (HSC) vascular niche regulating balance between HSC self-renewal and commitment.
V. Barbier, Johanna Erbani, Corrine E. Fiveash, Julie M. Davies, Joshua Tay, Michael R. Tallack, Jessica Lowe, J. Magnani, D. Pattabiraman, A. Perkins, J. Lisle, J. Rasko, J. Lévesque, I. Winkler   +13 more
semanticscholar   +1 more source

Intranasal delivery of E-selectin reduces atherosclerosis in ApoE-/- mice. [PDF]

PLoS ONE, 2011
Mucosal tolerance to E-selectin prevents stroke and protects against ischemic brain damage in experimental models of stroke studying healthy animals or spontaneously hypertensive stroke-prone rats.
Xinhui Li, Kory R Johnson, Mark Bryant, Abdel G Elkahloun, Marcelo Amar, Alan T Remaley, Ranil De Silva, John M Hallenbeck, Jacqueline A Quandt   +8 more
doaj   +1 more source

E-Selectin Is Associated with Daytime and 24-Hour Diastolic Blood Pressure Variability in Type 2 Diabetes

Biomedicines, 2022
E-selectin is an endothelial cell adhesion molecule involved in vascular inflammation. Elevated E-selectin has been reported in patients with high blood pressure and diabetes.
Dana Mihaela Ciobanu, Cornelia Bala, Adriana Rusu, Gabriel Cismaru, Gabriela Roman   +4 more
doaj   +1 more source

Bromelain decreases neutrophil interactions with P-selectin, but not E-selectin, in vitro by proteolytic cleavage of P-selectin glycoprotein ligand-1. [PDF]

PLoS ONE, 2013
Stem bromelain, a cysteine protease isolated from pineapples, is a natural anti-inflammatory treatment, yet its mechanism of action remains unclear. Curious as to whether bromelain might affect selectin-mediated leukocyte rolling, we studied the ability ...
Jessica M Banks, Christine T Herman, Ryan C Bailey   +2 more
doaj   +1 more source

Role of P-selectin in platelet sequestration in pulmonary capillaries during endotoxemia [PDF]

, 2006
Background: There is growing evidence that platelets accumulate in the lung and contribute to the pathogenesis of acute lung injury during endotoxemia.
Schenkat, Sonja, Kiefmann, Rainer, Dörger, Martina, Goetz, Alwin Eduard, Heckel, Kai   +4 more
core   +1 more source

Association of soluble E-selectin and morning blood pressure surge in patients with essential hypertension

Arterial Hypertension, 2022
BACKGROUND: Elevated soluble E-selectin which reflects a state of endothelial activation with subsequent vasoconstriction may elevate morning blood pressure (BP) surge.
Mohamed Yahia Abd Alkhalik, Mahmoud Ezz Elarab, Eman Masoud Abd El Gayed   +2 more
doaj   +1 more source

Bone Vascular Niche E-selectin Induces Mesenchymal-Epithelial Transition and Wnt Activation in Cancer Cells to Promote Bone Metastasis

Nature Cell Biology, 2019
How disseminated tumour cells engage specific stromal components in distant organs for survival and outgrowth is a critical but poorly understood step of the metastatic cascade.
M. Esposito, Nandini Mondal, T. Greco, Yong Wei, C. Spadazzi, Song-Chang Lin, Hanqiu Zheng, C. Cheung, J. Magnani, Sue-Hwa Lin, I. Cristea, R. Sackstein, Yibin Kang   +12 more
semanticscholar   +1 more source

Synthesis of a Potent Antagonist of E-Selectin

, 2016
A synthesis of an antagonist of E-selectin previously reported by a group at Novartis Pharma in Basel is described. An important feature involves the formation of an ether linkage based on a RhII-catalyzed reaction.
Vincent Mascitti (1393702), Olivier Rogel (2093572), Stephen Hanessian (1462600)   +2 more
core   +2 more sources