Results 41 to 50 of about 50,139,323 (325)

Identification and Expression Analysis of Zebrafish (Danio rerio) E-Selectin during Embryonic Development

Molecules, 2015
In this study, we cloned the full-length cDNA of E-selectin of zebrafish (Danio rerio), analyzed its expression pattern and preliminarily explored its biological function.
Guijin Sun, Kechun Liu, Xue Wang, Xiuhe Liu, Qiuxia He, Chung-Der Hsiao   +5 more
doaj   +1 more source

MAPK phosphatase-1 represents a novel antiinflammatory target of glucocorticoids in the human endothelium [PDF]

, 2007
Glucocorticoids are well-established anti- inflammatory drugs thought to mainly act by inhibition of proinflammatory transcription factors like NF-κB.
Timm Schroeder, Stefan Zahler, Eilken, H.M., Bubik, M.F., Vollmar, Angelika M., Alexandra K. Kiemer, Kiemer, Alexandra K., Zahler, S., Fürst, Robert, Robert Fürst, Schroeder, Timm, Martin F. Bubik, Angelika M. Vollmar, Hanna M. Eilken, Vollmar, A.M., Eilken, Hanna M., Fürst, R., Bubik, Martin F., Zahler, Stefan, Schroeder, T., Kiemer, A.K.   +20 more
core   +1 more source

E-selectin-targeting delivery of microRNAs by microparticles ameliorates endothelial inflammation and atherosclerosis

Scientific Reports, 2016
E-selectin is a surface marker of endothelial cell (EC) inflammation, one of the hallmarks of atherogenesis. Thus, we tested the hypothesis that delivery of microRNA (miR)-146a and miR-181b with an E-selectin-targeting multistage vector (ESTA-MSV) to ...
Shuang-Tao Ma, X. Tian, Yun-Rong Zhang, Chao-Feng Mu, Haifa Shen, J. Bismuth, H. Pownall, Yu Huang, Wing-Tak Wong   +8 more
semanticscholar   +1 more source

An Analysis of Trafficking Receptors Shows that CD44 and P-Selectin Glycoprotein Ligand-1 Collectively Control the Migration of Activated Human T-Cells

Frontiers in Immunology, 2017
Selectins guide the traffic of activated T-cells through the blood stream by mediating their tethering and rolling onto inflamed endothelium, in this way acting as beacons to help navigate them to sites of inflammation.
Amal J. Ali, Ayman F. Abuelela, Jasmeen S. Merzaban   +2 more
doaj   +1 more source

Data_Sheet_1_E-Selectin-Overexpressing Mesenchymal Stem Cell Therapy Confers Improved Reperfusion, Repair, and Regeneration in a Murine Critical Limb Ischemia Model.docx

, 2022
AimsNovel cell-based therapeutic angiogenic treatments for patients with critical limb ischemia may afford limb salvage. Mesenchymal stem cells (MSCs) do not overexpress E-selectin; however, we have previously demonstrated the cell-adhesion molecule's ...
Roberta M. Lassance-Soares (12021782), Zhao-Jun Liu (168517), Yulexi Y. Ortiz (12021776), Roberto I. Vazquez-Padron (12021785), Omaida C. Velazquez (12021788), Yan Li (23143), Punam P. Parikh (12021779), Hongwei Shao (493627), Hallie J. Quiroz (12021770), Samantha F. Valencia (12021773)   +9 more
core   +1 more source

Identification of thioaptamer ligand against E-selectin: potential application for inflamed vasculature targeting.

PLoS ONE, 2010
Active targeting of a drug carrier to a specific target site is crucial to provide a safe and efficient delivery of therapeutics and imaging contrast agents.
Aman P Mann, Anoma Somasunderam, René Nieves-Alicea, Xin Li, Austin Hu, Anil K Sood, Mauro Ferrari, David G Gorenstein, Takemi Tanaka   +8 more
doaj   +1 more source

Cell–specific Variation in E-selectin Ligand Expression Among Human Peripheral Blood Mononuclear Cells: Implications for Immunosurveillance and Pathobiology

Journal of Immunology, 2017
Both host defense and immunopathology are shaped by the ordered recruitment of circulating leukocytes to affected sites, a process initiated by binding of blood-borne cells to E-selectin displayed at target endothelial beds. Accordingly, knowledge of the
Mariana Silva, R. Fung, Conor Donnelly, P. Videira, R. Sackstein   +4 more
semanticscholar   +1 more source

Monocyte induction of E-selectin-mediated endothelial activation releases VE-cadherin junctions to promote tumor cell extravasation in the metastasis cascade

Cancer Research, 2016
Tumor cells interact with blood constituents and these interactions promote metastasis. Selectins are vascular receptors facilitating interactions of tumor cells with platelets, leukocytes and endothelium but the role of endothelial E-selectin remains ...
Irina Häuselmann, Marko Roblek, Darya Protsyuk, V. Huck, L. Knopfová, Sandra Grässle, A. Bauer, S. Schneider, L. Borsig   +8 more
semanticscholar   +1 more source

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Staining of E-selectin ligands on paraffin-embedded sections of tumor tissue

BMC Cancer, 2018
Background The E-selectin ligands expressed by cancer cells mediate adhesion of circulating cancer cells to endothelial cells, as well as within tissue microenvironments important for tumor progression and metastasis.
Mylène A. Carrascal, Catarina Talina, Paula Borralho, A. Gonçalo Mineiro, Ana Raquel Henriques, Cláudia Pen, Manuela Martins, Sofia Braga, Robert Sackstein, Paula A. Videira   +9 more
doaj   +1 more source