Results 61 to 70 of about 21,662,479 (296)

Arterial stiffness and endothelial inflammation in prediabetes and newly diagnosed diabetes patients

Archives of Endocrinology and Metabolism, 2015
ObjectiveThere is a growing body of data supporting the association between diabetes and microcirculatory disfunction. We aimed to study e-selectin levels, and their associations with serum markers of inflammation and arterial stiffness in prediabetes ...
Mustafa Çakar, Şevket Balta, Hakan Şarlak, Muharrem Akhan, Sait Demirkol, Murat Karaman, Seyit Ahmet Ay, Ömer Kurt, Tuncer Çayci, Satılmış İnal, Şeref Demirbaş   +10 more
doaj   +1 more source

Lectins on a roll: the structure of E-selectin [PDF]

Structure, 1994
The crystal structure of the lectin/EGF portion of E-selectin confirms anticipated similarities with homologous domains, but reveals some surprising features that emphasize the limitations of homology modelling.
openaire   +2 more sources

CD177 Deficiency Defines a Stable Subtype of Human Neutrophil Granulocytes with Tumor Promoting Activity

Advanced Science, EarlyView.
Human neutrophils exist as two epigenetically imprinted subtypes defined by stable CD177 expression or absence — a ratio that persists across time, circadian rhythms, and inflammation. CD177− neutrophils display a distinct molecular landscape enriched in arginase 1 and lipid metabolism markers, accumulate in head‐and‐neck tumors, and associate with ...
Marcel Jung, Alexander Beer, Susmita Ghosh, Ekaterina Pylaeva, Belal Alshaar, Tobias Tertel, Nils Bastian Leimkühler, Thomas Schroeder, Janine Gronewold, Nina Hagemann, Ayan Mohamud Yusuf, Benedikt Frank, Yiqiao Zhang, Dennis Nagel, Kim Schloeßer, Laura Karsch, Emily Hedtfeld, Sabrina Lohmann, Kathrin Blank, Andreas Kraus, Max Krumbein, Nastassia Kabankova, Hongxiao Wang, Almke Bader, Mathis Richter, Fengjun Zhang, Raphael Chevre, Bernd Giebel, Stephan Lang, Anika Grüneboom, Daniela Maier‐Begandt, Anja Hasenberg, Oliver Soehnlein, Hans Christian Reinhardt, Sven Heiles, Jianxu Chen, Jadwiga Jablonska, Albert Sickmann, Dirk M. Hermann, Matthias Gunzer   +39 more
wiley   +1 more source

Dynamics of cytokine induced E-selectin expression in endothelial cells [PDF]

, 2023
E-selectin is a cell adhesion molecule, expressed on the cell surface of endothelial cells in response to inflammatory cytokines. Once expressed, E-selectin mediates tethering and rolling of circulating leukocytes so that they can be extravasated to ...
Ogrodzinski, Lydia
core   +2 more sources

E-selectin ligands recognised by heca452 induce drug resistance in myeloma, which is overcome by the e-selectin antagonist, gmi-1271

, 2017
Multiple myeloma (MM) is characterized by the clonal expansion and metastatic spread of malignant plasma cells to multiple sites in the bone marrow (BM).
O'Dwyer, M E, O\u27Dwyer, M E, Natoni, A, Kirkham-McCarthy, L, Jha, A, C McEllistrim, A Jha, Oliva, I, S K Kumar, Glavey, S V, J L Magnani, McEllistrim, C, A Natoni, Smith, T A G, Kumar, S K, N Keane, M S Raab, Andrulis, M, Locatelli-Hoops, S C, S C Locatelli-Hoops, W E Fogler, E Ellert, T A G Smith, Ellert, E, Keane, N, Raab, M S, I Oliva, Fogler, W E, M Andrulis, Magnani, J L, C Connolly, M E O'Dwyer, S V Glavey, L Kirkham-McCarthy, Connolly, C   +34 more
core   +1 more source

Pathogenic PF4/Polyanion ELISA‐Negative Antibodies in HIT

American Journal of Hematology, EarlyView.
ABSTRACT Background Platelet factor 4‐polyanion enzyme‐linked immunosorbent assays (ELISAs) are considered highly sensitive for diagnosing heparin‐induced thrombocytopenia (HIT), such that current practice guidelines recommend use of ELISA‐negative results to exclude HIT.
Adam J. Kanack, Noah P. Splinter, Emily E. Mauch, Leben Tefera, Morayma Reyes Gil, Sakshi Jasra, Andrew Goodwin, Kristi J. Smock, Hadiyah Ahmad, Aneel Ashrani, Nathaniel L. Robinson, Ana I. Casanegra, Curtis G. Jones, Shannon M. Pechauer, Erin Yttre, Richard H. Aster, Mindy C. Kohlhagen, Rachel R. Leger, Gretchen Johns, David L. Murray, Lu Zhou, Demin Wang, Renren Wen, Dong Chen, Rajiv K. Pruthi, Anand Padmanabhan   +25 more
wiley   +1 more source

A cell-extrinsic ligand acquired by activated T cells in lymph node can bridge L-selectin and P-selectin

, 2018
P-selectin expressed on activated endothelia and platelets supports recruitment of leukocytes expressing P-selectin ligand to sites of inflammation.
Michelle C Tra, Douglas A. Carlow (5916725), Michelle C. Tra (5916728), Hermann J Ziltener, Hermann J. Ziltener (361706), Douglas A Carlow   +5 more
core   +1 more source

Research progress on biomarkers of traumatic brain injury

Animal Models and Experimental Medicine, EarlyView.
Traumatic brain injury: From primary insult to secondary neuroinflammation and degeneration. Abstract Traumatic brain injury (TBI) is a common disorder of the nervous system and has become a leading cause of death and disability worldwide, imposing a substantial burden on patients and their social circles. Its main symptoms include dyskinesia, language
Xuting Shen, Si Cheng, Shuyi Chen, Mengyue Wang, Tangying Li, Weicheng Xu, Yifan Zhang, Ping Yuan, Lei Shi   +8 more
wiley   +1 more source

E-Selectin S128R Polymorphism Leads to Severe Asthma

Iranian Journal of Allergy, Asthma and Immunology, 2007
The E-selectin mediates the interaction of activated endothelial cells with leukocytes and plays a fundamental role in the pathogenesis of asthma. It has been suggested that an S/R (Serine128Arginine) polymorphism of E-selectin alters ligand binding ...
Ebrahim Nadi, Mehrdad Hajilooi, Fatemeh Zeraati, Mostafa Ansari, Sasan Tavana, Sayed Hamid Hashemi, Alireza Rafiei   +6 more
doaj  

Regulation of PSGL-1 Interactions with L-selectin, P-selectin, and E-selectin

, 2005
P-selectin glycoprotein ligand-1 (PSGL-1) interactions with selectins regulate leukocyte migration in inflammatory lesions. In mice, selectin ligand activity regulating leukocyte recruitment and lymphocyte homing into lymph nodes results from the sum of ...
Giraud, S., Bernimoulin, M.P., Michael Pierre Bernimoulin, Spertini, O., Sylvain Giraud, Joffraud, M., Bénédicte Baïsse, Olivier Spertini, Manuel Martinez, Schapira, M., Baïsse, B., Magali Joffraud, Marc Schapira, Martinez, M.   +13 more
core   +1 more source