Results 21 to 30 of about 76,202 (273)

Pathologic evaluation of tumor-associated macrophage density and vessel inflammation in invasive breast carcinomas [PDF]

, 2017
Tumor-associated macrophages (TAMs) are major constituents of the tumor microenvironment in solid tumors and have been implicated as mediators of tumor progression, invasion and metastasis.
Adhikari, Smita, Chervoneva, Inna, Hasan, Nafis, Leslie, Macall, Morita, Yoshihiro, Rui, Hallgeir, Tanaka, Takemi, Zhang, Roy   +7 more
core   +2 more sources

Association of soluble E-selectin and morning blood pressure surge in patients with essential hypertension

Arterial Hypertension, 2022
BACKGROUND: Elevated soluble E-selectin which reflects a state of endothelial activation with subsequent vasoconstriction may elevate morning blood pressure (BP) surge.
Mohamed Yahia Abd Alkhalik, Mahmoud Ezz Elarab, Eman Masoud Abd El Gayed   +2 more
doaj   +1 more source

Identification and Expression Analysis of Zebrafish (Danio rerio) E-Selectin during Embryonic Development

Molecules, 2015
In this study, we cloned the full-length cDNA of E-selectin of zebrafish (Danio rerio), analyzed its expression pattern and preliminarily explored its biological function.
Guijin Sun, Kechun Liu, Xue Wang, Xiuhe Liu, Qiuxia He, Chung-Der Hsiao   +5 more
doaj   +1 more source

P-selectin glycoprotein ligand-1 forms dimeric interactions with E-selectin but monomeric interactions with L-selectin on cell surfaces. [PDF]

PLoS ONE, 2013
Interactions of selectins with cell surface glycoconjugates mediate the first step of the adhesion and signaling cascade that recruits circulating leukocytes to sites of infection or injury.
Yan Zhang, Ning Jiang, Veronika I Zarnitsyna, Arkadiusz G Klopocki, Rodger P McEver, Cheng Zhu   +5 more
doaj   +1 more source

MAPK phosphatase-1 represents a novel antiinflammatory target of glucocorticoids in the human endothelium [PDF]

, 2007
Glucocorticoids are well-established anti- inflammatory drugs thought to mainly act by inhibition of proinflammatory transcription factors like NF-κB.
Bubik, Martin F., Eilken, Hanna M., Fürst, Robert, Kiemer, Alexandra K., Schroeder, Timm, Vollmar, Angelika M., Zahler, Stefan   +6 more
core   +1 more source

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

A targeting microbubble for ultrasound molecular imaging [PDF]

, 2015
Microbubbles conjugated with targeting ligands are used as contrast agents for ultrasound molecular imaging. However, they often contain immunogenic (strept)avidin, which impedes application in humans. Although targeting bubbles not employing the biotin-(
Eckersley, R, Haskard, DO, McConnell, E, Nihoyannopoulos, P, Nourshargh, S, Seddon, JM, Sennoga, CA, Tang, M-X, Yeh, JS-M   +8 more
core   +5 more sources

An Analysis of Trafficking Receptors Shows that CD44 and P-Selectin Glycoprotein Ligand-1 Collectively Control the Migration of Activated Human T-Cells

Frontiers in Immunology, 2017
Selectins guide the traffic of activated T-cells through the blood stream by mediating their tethering and rolling onto inflamed endothelium, in this way acting as beacons to help navigate them to sites of inflammation.
Amal J. Ali, Ayman F. Abuelela, Jasmeen S. Merzaban   +2 more
doaj   +1 more source

Identification of thioaptamer ligand against E-selectin: potential application for inflamed vasculature targeting.

PLoS ONE, 2010
Active targeting of a drug carrier to a specific target site is crucial to provide a safe and efficient delivery of therapeutics and imaging contrast agents.
Aman P Mann, Anoma Somasunderam, René Nieves-Alicea, Xin Li, Austin Hu, Anil K Sood, Mauro Ferrari, David G Gorenstein, Takemi Tanaka   +8 more
doaj   +1 more source

Multitasking E selectin [PDF]

Science-Business eXchange, 2012
Researchers at the Mater Medical Research Institute, The University of Queensland and GlycoMimetics have mouse data showing that E selectin antagonists can alleviate side effects of chemotherapy brought about by exhaustion of the self-renewal capacity of hematopoietic stem cells.
openaire   +1 more source