Results 21 to 30 of about 21,662,479 (296)
Synthesis of a Potent Antagonist of E-Selectin
, 2016 A synthesis of an antagonist of E-selectin previously reported by a group at Novartis Pharma in Basel is described. An important feature involves the formation of an ether linkage based on a RhII-catalyzed reaction.
Vincent Mascitti (1393702) +2 more
core +2 more sources
Arterial Hypertension, 2022 BACKGROUND: Elevated soluble E-selectin which reflects a state of endothelial activation with subsequent vasoconstriction may elevate morning blood pressure (BP) surge.
Mohamed Yahia Abd Alkhalik +2 more
doaj +1 more source
Molecules, 2015 In this study, we cloned the full-length cDNA of E-selectin of zebrafish (Danio rerio), analyzed its expression pattern and preliminarily explored its biological function.
Guijin Sun +5 more
doaj +1 more source
L1CAM as an E-selectin Ligand in Colon Cancer [PDF]
International Journal of Molecular Sciences, 2020 Metastasis is the main cause of death among colorectal cancer (CRC) patients. E-selectin and its carbohydrate ligands, including sialyl Lewis X (sLeX) antigen, are key players in the binding of circulating tumor cells to the endothelium, which is one of the major events leading to organ invasion. Nevertheless, the identity of the glycoprotein scaffolds
Fanny M. Deschepper +8 more
openaire +5 more sources
MAPK phosphatase-1 represents a novel antiinflammatory target of glucocorticoids in the human endothelium [PDF]
, 2007 Glucocorticoids are well-established anti- inflammatory drugs thought to mainly act by inhibition of proinflammatory transcription factors like NF-κB.
Timm Schroeder +20 more
core +1 more source
Towards the synthesis of a macrocyclic E-selectin antagonist [PDF]
, 2006 Towards the Synthesis of a Macrocyclic E-selectin Antagonis: Introduction: Selectins are involved in the orderly migration of leukocytes from blood vessels to sites of inflammation.
Marti, Sébastien Jérôme Georges
core +1 more source
Frontiers in Immunology, 2017 Selectins guide the traffic of activated T-cells through the blood stream by mediating their tethering and rolling onto inflamed endothelium, in this way acting as beacons to help navigate them to sites of inflammation.
Amal J. Ali +2 more
doaj +1 more source
Hepatology, EarlyView., 2022 CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli +13 more
wiley +1 more source
PLoS ONE, 2010 Active targeting of a drug carrier to a specific target site is crucial to provide a safe and efficient delivery of therapeutics and imaging contrast agents.
Aman P Mann +8 more
doaj +1 more source
Characterization of equine E‐selectin
Immunology, 2001 SummaryExpression of E‐selectin on activated endothelium is a critical initial step that leads to extravasation of leucocytes during inflammation, yet E‐selectin is largely uncharacterized in several animal species including the horse. We have sequenced and compared E‐selectin genes derived from activated cultures of purified equine (horse), cervid ...
J F, Hedges +5 more
openaire +3 more sources